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ChatGPT has drawn considerable attention from both the general public and domain experts with its remarkable text generation capabilities. This has subsequently led to the emergence of diverse applications in the field of biomedicine and…

The performance of deep learning-based natural language processing systems is based on large amounts of labeled training data which, in the clinical domain, are not easily available or affordable. Weak supervision and in-context learning…

Computation and Language · Computer Science 2025-04-02 Enshuo Hsu , Kirk Roberts

Improving performance on complex tasks and enabling interpretable decision making in large language models (LLMs), especially for clinical applications, requires effective reasoning. Yet this remains challenging without supervised…

Computation and Language · Computer Science 2025-05-26 Che Liu , Haozhe Wang , Jiazhen Pan , Zhongwei Wan , Yong Dai , Fangzhen Lin , Wenjia Bai , Daniel Rueckert , Rossella Arcucci

Tumor documentation in Germany is largely done manually, requiring reading patient records and entering data into structured databases. Large language models (LLMs) could potentially enhance this process by improving efficiency and…

Computation and Language · Computer Science 2025-08-08 Stefan Lenz , Arsenij Ustjanzew , Marco Jeray , Meike Ressing , Torsten Panholzer

State-of-the-art supervised NLP models achieve high accuracy but are also susceptible to failures on inputs from low-data regimes, such as domains that are not represented in training data. As an approximation to collecting ground-truth…

Computation and Language · Computer Science 2023-06-29 Parikshit Bansal , Amit Sharma

Large Language Models (LLMs) recently achieved great success in medical text summarization by simply using in-context learning. However, these recent efforts do not perform fine-grained evaluations under difficult settings where LLMs might…

Computation and Language · Computer Science 2026-04-22 Gunjan Balde , Soumyadeep Roy , Mainack Mondal , Niloy Ganguly

Large Language Models (LLMs) have demonstrated proficiency in a wide array of natural language processing tasks. However, its effectiveness over discourse-level event relation extraction (ERE) tasks remains unexplored. In this paper, we…

Computation and Language · Computer Science 2025-02-25 Kangda Wei , Aayush Gautam , Ruihong Huang

Detecting jailbreak attempts in clinical training large language models (LLMs) requires accurate modeling of linguistic deviations that signal unsafe or off-task user behavior. Prior work on the 2-Sigma clinical simulation platform showed…

Artificial Intelligence · Computer Science 2026-02-17 Tri Nguyen , Huy Hoang Bao Le , Lohith Srikanth Pentapalli , Laurah Turner , Kelly Cohen

Large language models (LLMs) with billions of parameters and pretrained on massive amounts of data are now capable of near or better than state-of-the-art performance in a variety of downstream natural language processing tasks. Neural…

Computation and Language · Computer Science 2024-07-08 Victor Agostinelli , Max Wild , Matthew Raffel , Kazi Ahmed Asif Fuad , Lizhong Chen

Understanding the intricate interplay among sequence, structure, and function remains a fundamental challenge in proteomics. The sequence-structure-function paradigm posits that biological roles are governed by the tertiary geometric…

Biomolecules · Quantitative Biology 2026-05-14 Hongwang Xiao , Wenjun Lin , Xi Chen , Hui Wang , Kai Chen , Jiashan Li , Yuancheng Sun , Sicheng Dai , Boya Wu , Qiwei Ye

Recent advances in natural language processing (NLP) have been driven bypretrained language models like BERT, RoBERTa, T5, and GPT. Thesemodels excel at understanding complex texts, but biomedical literature, withits domain-specific…

Computation and Language · Computer Science 2025-07-28 K. Sahit Reddy , N. Ragavenderan , Vasanth K. , Ganesh N. Naik , Vishalakshi Prabhu , Nagaraja G. S

Systematic reviews and meta-analyses rely on converting narrative articles into structured, numerically grounded study records. Despite rapid advances in large language models (LLMs), it remains unclear whether they can meet the structural…

Computation and Language · Computer Science 2026-02-12 Zhiyin Tan , Jennifer D'Souza

The escalating volume of collected healthcare textual data presents a unique challenge for automated Multi-Label Text Classification (MLTC), which is primarily due to the scarcity of annotated texts for training and their nuanced nature.…

Computation and Language · Computer Science 2025-03-04 Hajar Sakai , Sarah S. Lam

The modeling of bio-molecular system across molecular scales remains a central challenge in scientific research. Large language models (LLMs) are increasingly applied to bio-molecular discovery, yet systematic evaluation across multi-scale…

Machine Learning · Computer Science 2026-04-07 Yaxin Xu , Yue Zhou , Tianyu Zhao , Fengwei An , Zhixiang Ren

Frontier large language models (LLMs) are developed by researchers and practitioners with skewed cultural backgrounds and on datasets with skewed sources. However, LLMs' (lack of) multicultural knowledge cannot be effectively assessed with…

While large language models (LLMs) demonstrate reasonable zero-shot capability across many downstream tasks, fine-tuning is a common practice to improve their performance. However, a task's data efficiency--i.e., the number of fine-tuning…

Machine Learning · Computer Science 2026-01-01 Gyung Hyun Je , Colin Raffel

Large Language Models (LLMs) have become extremely potent instruments with exceptional capacities for comprehending and producing human-like text in a wide range of applications. However, the increasing size and complexity of LLMs present…

Machine Learning · Computer Science 2024-06-18 Yingbing Huang , Lily Jiaxin Wan , Hanchen Ye , Manvi Jha , Jinghua Wang , Yuhong Li , Xiaofan Zhang , Deming Chen

Although large language models (LLMs) are increasingly used as annotators at scale, they are typically treated as a pragmatic fallback rather than a faithful estimator of human perspectives. This work challenges that presumption. By framing…

Artificial Intelligence · Computer Science 2026-04-21 Hasan Amin , Harry Yizhou Tian , Xiaoni Duan , Chien-Ju Ho , Rajiv Khanna , Ming Yin

When complex SQL queries suffer slow executions despite query optimization, DBAs typically invoke automated query rewriting tools to recommend ``lean'' equivalents that are conducive to faster execution. The rewritings are usually achieved…

Databases · Computer Science 2025-09-03 Sriram Dharwada , Himanshu Devrani , Jayant Haritsa , Harish Doraiswamy

Tools to explore scientific literature are essential for scientists, especially in biomedicine, where about a million new papers are published every year. Many such tools provide users the ability to search for specific entities (e.g.…

Computation and Language · Computer Science 2021-07-05 Sunil Mohan , Rico Angell , Nick Monath , Andrew McCallum