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Large Language Models (LLMs) have emerged as transformative tools in the healthcare sector, demonstrating remarkable capabilities in natural language understanding and generation. However, their proficiency in numerical reasoning,…

Artificial Intelligence · Computer Science 2025-01-27 Arjun R. Malghan

Large language models (LLMs) show promise for clinical reasoning and decision support, but evaluation in realistic, electronic health record-congruent settings remains limited. Existing benchmarks often rely on static datasets or…

Computation and Language · Computer Science 2026-05-29 Valentina Bui Muti , Eugénie Dulout , Ziquan Fu

As large language models (LLMs) become increasingly integrated into clinical decision-making, ensuring transparent and trustworthy reasoning is essential. However, existing evaluation strategies of LLMs' medical reasoning capability either…

Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani

Artificial intelligence (AI) and large language models (LLMs) in healthcare require advanced clinical skills (CS), yet current benchmarks fail to evaluate these comprehensively. We introduce MedQA-CS, an AI-SCE framework inspired by medical…

Artificial Intelligence · Computer Science 2026-01-21 Zonghai Yao , Zihao Zhang , Chaolong Tang , Xingyu Bian , Youxia Zhao , Zhichao Yang , Junda Wang , Huixue Zhou , Won Seok Jang , Feiyun Ouyang , Hong Yu

Reliable uncertainty quantification (UQ) is essential when employing large language models (LLMs) in high-risk domains such as clinical question answering (QA). In this work, we evaluate uncertainty estimation methods for clinical QA…

Computation and Language · Computer Science 2026-01-27 Alberto Testoni , Iacer Calixto

Large language models (LLMs) have demonstrated remarkable performance on various medical benchmarks, but their capabilities across different cognitive levels remain underexplored. Inspired by Bloom's Taxonomy, we propose a…

Computation and Language · Computer Science 2025-06-11 Yuxuan Zhou , Xien Liu , Chenwei Yan , Chen Ning , Xiao Zhang , Boxun Li , Xiangling Fu , Shijin Wang , Guoping Hu , Yu Wang , Ji Wu

Large Language Models (LLMs), although powerful in general domains, often perform poorly on domain-specific tasks such as medical question answering (QA). In addition, LLMs tend to function as "black-boxes", making it challenging to modify…

Computation and Language · Computer Science 2024-08-19 Yucheng Shi , Shaochen Xu , Tianze Yang , Zhengliang Liu , Tianming Liu , Quanzheng Li , Xiang Li , Ninghao Liu

The growing capabilities of Large Language Models (LLMs) show significant potential to enhance healthcare by assisting medical researchers and physicians. However, their reliance on static training data is a major risk when medical…

Computation and Language · Computer Science 2025-09-05 Juraj Vladika , Mahdi Dhaini , Florian Matthes

Integrating large language models (LLMs) like DeepSeek R1 into healthcare requires rigorous evaluation of their reasoning alignment with clinical expertise. This study assesses DeepSeek R1's medical reasoning against expert patterns using…

Computation and Language · Computer Science 2025-04-02 Birger Moell , Fredrik Sand Aronsson , Sanian Akbar

Medical question answering (QA) benchmarks often focus on multiple-choice or fact-based tasks, leaving open-ended answers to real patient questions underexplored. This gap is particularly critical in mental health, where patient questions…

Computation and Language · Computer Science 2026-05-15 Yahan Li , Jifan Yao , John Bosco S. Bunyi , Adam C. Frank , Angel Hsing-Chi Hwang , Ruishan Liu

High-performing medical Large Language Models (LLMs) typically require extensive fine-tuning with substantial computational resources, limiting accessibility for resource-constrained healthcare institutions. This study introduces a…

Computation and Language · Computer Science 2025-10-17 Ziad Elshaer , Essam A. Rashed

Medical tasks such as diagnosis and treatment planning require precise and complex reasoning, particularly in life-critical domains. Unlike mathematical reasoning, medical reasoning demands meticulous, verifiable thought processes to ensure…

Computation and Language · Computer Science 2025-04-08 Juncheng Wu , Wenlong Deng , Xingxuan Li , Sheng Liu , Taomian Mi , Yifan Peng , Ziyang Xu , Yi Liu , Hyunjin Cho , Chang-In Choi , Yihan Cao , Hui Ren , Xiang Li , Xiaoxiao Li , Yuyin Zhou

Reading and understanding text is one important component in computer aided diagnosis in clinical medicine, also being a major research problem in the field of NLP. In this work, we introduce a question-answering task called MedQA to study…

Computation and Language · Computer Science 2018-03-01 Xiao Zhang , Ji Wu , Zhiyang He , Xien Liu , Ying Su

Large Language Model (LLM) has gained popularity and achieved remarkable results in open-domain tasks, but its performance in real industrial domain-specific scenarios is average due to its lack of specific domain knowledge. This issue has…

Computation and Language · Computer Science 2023-10-17 Fangkai Yang , Pu Zhao , Zezhong Wang , Lu Wang , Jue Zhang , Mohit Garg , Qingwei Lin , Saravan Rajmohan , Dongmei Zhang

The recent success of Large Language Models (LLMs) has had a significant impact on the healthcare field, providing patients with medical advice, diagnostic information, and more. However, due to a lack of professional medical knowledge,…

Computation and Language · Computer Science 2024-06-27 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Xiang Wan , Feng Jiang , Benyou Wang

Large language models (LLMs) have shown promise for generative and knowledge-intensive tasks including question-answering (QA) tasks. However, the practical deployment still faces challenges, notably the issue of "hallucination", where…

Computation and Language · Computer Science 2023-10-11 Ziwei Ji , Tiezheng Yu , Yan Xu , Nayeon Lee , Etsuko Ishii , Pascale Fung

Large language models (LLMs) exhibit extensive medical knowledge but are prone to hallucinations and inaccurate citations, which pose a challenge to their clinical adoption and regulatory compliance. Current methods, such as Retrieval…

While Small Language Models (SLMs) have demonstrated promising performance on an increasingly wide array of commonsense reasoning benchmarks, current evaluation practices rely almost exclusively on the accuracy of their final answers,…

Computation and Language · Computer Science 2026-04-21 Francesco Maria Molfese , Luca Moroni , Ciro Porcaro , Simone Conia , Roberto Navigli

Although contemporary large language models (LMs) demonstrate impressive question-answering capabilities, their answers are typically the product of a single call to the model. This entails an unwelcome degree of opacity and compromises…

Artificial Intelligence · Computer Science 2022-08-31 Antonia Creswell , Murray Shanahan
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