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Large language models ($\textbf{LLMs}$) have emerged as a powerful method for discovery. Instead of utilizing numerical data, LLMs utilize associated variable $\textit{semantic metadata}$ to predict variable relationships. Simultaneously,…

Machine Learning · Computer Science 2025-04-15 Alex Havrilla , David Alvarez-Melis , Nicolo Fusi

Molecules are graphs, but large language models~(LLMs) are usually asked to reason about them through linear strings. The most popular molecular representation, SMILES, compresses atoms, bonds, branches and rings into a compact sequence in…

Biomolecules · Quantitative Biology 2026-05-19 Zhiyuan Yan , Chen Liu , Boxuan Zhao , Kaiqing Lin , Jixiang Zhao , Yimi Wang , Liuzhenghao Lv , Hao Li , Shanzhuo Zhang , Li Yuan , Fanyang Mo

Large Language Models (LLMs) have achieved great success in various reasoning tasks. In this work, we focus on the graph reasoning ability of LLMs. Although theoretical studies proved that LLMs are capable of handling graph reasoning tasks,…

Computation and Language · Computer Science 2025-01-09 Xinnan Dai , Qihao Wen , Yifei Shen , Hongzhi Wen , Dongsheng Li , Jiliang Tang , Caihua Shan

In this paper, we aim to develop a large language model (LLM) with the reasoning ability on complex graph data. Currently, LLMs have achieved very impressive performance on various natural language learning tasks, extensions of which have…

Artificial Intelligence · Computer Science 2023-05-12 Jiawei Zhang

While multi-modal models have successfully integrated information from image, video, and audio modalities, integrating graph modality into large language models (LLMs) remains unexplored. This discrepancy largely stems from the inherent…

Computation and Language · Computer Science 2023-10-13 Yuanchun Shen , Ruotong Liao , Zhen Han , Yunpu Ma , Volker Tresp

Large language models (LLMs) are introducing a paradigm shift in molecular discovery by enabling text-guided interaction with chemical spaces through natural language, symbolic notations, with emerging extensions to incorporate multi-modal…

Machine Learning · Computer Science 2025-05-23 Ziqing Wang , Kexin Zhang , Zihan Zhao , Yibo Wen , Abhishek Pandey , Han Liu , Kaize Ding

Various human-designed prompt engineering techniques have been proposed to improve problem solvers based on Large Language Models (LLMs), yielding many disparate code bases. We unify these approaches by describing LLM-based agents as…

Artificial Intelligence · Computer Science 2024-08-23 Mingchen Zhuge , Wenyi Wang , Louis Kirsch , Francesco Faccio , Dmitrii Khizbullin , Jürgen Schmidhuber

We focus on a conversational question answering task which combines the challenges of understanding questions in context and reasoning over evidence gathered from heterogeneous sources like text, knowledge graphs, tables, and infoboxes. Our…

Computation and Language · Computer Science 2024-07-16 Parag Jain , Mirella Lapata

Large Language Models (LLMs) have achieved remarkable success across various domains. However, they still face significant challenges, including high computational costs for training and limitations in solving complex reasoning problems.…

Machine Learning · Computer Science 2025-05-20 Hang Gao , Chenhao Zhang , Tie Wang , Junsuo Zhao , Fengge Wu , Changwen Zheng , Huaping Liu

Developments in Graph-Language Models (GLMs) aim to integrate the structural reasoning capabilities of Graph Neural Networks (GNNs) with the semantic understanding of Large Language Models (LLMs). However, we demonstrate that current…

Computation and Language · Computer Science 2025-08-29 Soham Petkar , Hari Aakash K , Anirudh Vempati , Akshit Sinha , Ponnurangam Kumarauguru , Chirag Agarwal

The prediction of physicochemical properties from molecular structures is a crucial task for artificial intelligence aided molecular design. A growing number of Graph Neural Networks (GNNs) have been proposed to address this challenge.…

Machine Learning · Computer Science 2020-11-17 Shuo Zhang , Yang Liu , Lei Xie

Due to the advantages of hypergraphs in modeling high-order relationships in complex systems, they have been applied to higher-order clustering, hypergraph neural networks and computer vision. These applications rely heavily on access to…

Social and Information Networks · Computer Science 2025-10-15 Bingqiao Gu , Jiale Zeng , Xingqin Qi , Dong Li

The success of large pretrained Transformers is closely tied to tokenizers, which convert raw input into discrete symbols. Extending these models to graph-structured data remains a significant challenge. In this work, we introduce a graph…

Machine Learning · Computer Science 2026-03-13 Zeyuan Guo , Enmao Diao , Cheng Yang , Chuan Shi

Large language models (LLMs) have recently achieved remarkable success in various reasoning tasks in the field of natural language processing. This success of LLMs has also motivated their use in graph-related tasks. Among others, recent…

Machine Learning · Computer Science 2024-09-27 Konstantinos Skianis , Giannis Nikolentzos , Michalis Vazirgiannis

Graph representation learning, involving both node features and graph structures, is crucial for real-world applications but often encounters pervasive noise. State-of-the-art methods typically address noise by focusing separately on node…

Machine Learning · Computer Science 2024-10-17 Guangxin Su , Yifan Zhu , Wenjie Zhang , Hanchen Wang , Ying Zhang

Existing benchmarks like NLGraph and GraphQA evaluate LLMs on graphs by focusing mainly on pairwise relationships, overlooking the high-order correlations found in real-world data. Hypergraphs, which can model complex beyond-pairwise…

Artificial Intelligence · Computer Science 2024-10-17 Yifan Feng , Chengwu Yang , Xingliang Hou , Shaoyi Du , Shihui Ying , Zongze Wu , Yue Gao

Despite the promising results of large multimodal models (LMMs) in complex vision-language tasks that require knowledge, reasoning, and perception abilities together, we surprisingly found that these models struggle with simple tasks on…

Graphics · Computer Science 2025-03-17 Kai Zhang , Jianwei Yang , Jeevana Priya Inala , Chandan Singh , Jianfeng Gao , Yu Su , Chenglong Wang

The integration of multi-omic data is pivotal for understanding complex diseases, but its high dimensionality and noise present significant challenges. Graph Neural Networks (GNNs) offer a robust framework for analyzing large-scale…

Quantitative Methods · Quantitative Biology 2024-12-23 Heming Zhang , Di Huang , Yixin Chen , Fuhai Li

The application of large language models (LLMs) to graph data has attracted a lot of attention recently. LLMs allow us to use deep contextual embeddings from pretrained models in text-attributed graphs, where shallow embeddings are often…

Artificial Intelligence · Computer Science 2025-02-19 Shima Khoshraftar , Niaz Abedini , Amir Hajian

With the rapid advancement of large language models (LLMs), classic graph learning tasks have greatly benefited from LLMs, including improved encoding of textual features, more efficient construction of graphs from text, and enhanced…

Artificial Intelligence · Computer Science 2026-05-05 Xiyuan Wang , Yi Hu , Yanbo Wang , Chuan Shi , Muhan Zhang