Related papers: Controlling tissue size by active fracture
We analyze systems of clusters and interacting upon colliding---a collision between two clusters may lead to merging or fragmentation---and we also investigate the influence of additional spontaneous fragmentation events. We consider both…
Developing epithelial tissues coordinate cell proliferation and mechanical forces to achieve proper size and shape. As epithelial cells tightly adhere together to form the confluent tissue, the distribution of cell areas significantly…
Bacteria can spontaneously develop collective motions by aligning their motions in dense systems. Here, we show that bacteria can also respond collectively to an alternating electrical field and form dynamic clusters oscillating at the same…
A major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring at the microscopic level. In this paper we describe a…
Non-equilibrium cluster-cluster aggregation of particles diffusing in or at the cell membrane has been hypothesized to lead to domains of finite size in different biological contexts such as lipid rafts, cell adhesion complexes, or…
The spatiotemporal coordination and regulation of cell proliferation is fundamental in many aspects of development and tissue maintenance. Cells have the ability to adapt their division rates in response to mechanical constraints, yet we do…
The aim of this review article is to give a comprehensive description of the scaling properties detected for the distribution of cosmic structures. Due to the great variety of statistical methods to describe the large-scale structure of the…
Cell growth in size is a complex process coordinated by intrinsic and environmental signals. In a recent work [Tzur et al., Science, 2009, 325:167-171], size distributions in an exponentially growing population of mammalian cells were used…
We simulate the dynamics of fractal star clusters, in order to investigate the evolution of substructure in recently formed clusters. The velocity dispersion is found to be the key parameter determining the survival of substructure. In…
Clusters of infected individuals are defined on data from health laboratories, but this quantity has not been defined and characterized by epidemy models on statistical physics. For a system of mobile agents we simulate a model of infection…
A fundamental question in biology is to understand how patterns and shapes emerge from the collective interplay of large numbers of cells. Cells forming two-dimensional epithelial tissues behave as active materials that undergo remodeling…
Biological cells use droplets to separate components and spatially control their interior. Experiments demonstrate that the complex, crowded cellular environment affects the droplet arrangement and their sizes. To understand this behavior,…
Establishing a quantitative connection between the population growth rate and the generation times of single cells is a prerequisite for understanding evolutionary dynamics of microbes. However, existing theories fail to account for the…
Objectives: In this study, we quantify the growth variability of tumour cell clones from a human leukemia cell line. Materials and methods: We have used microplate spectrophotometry to measure the growth kinetics of hundreds of individual…
Recent studies aimed at investigating artificial analogs of bacterial colonies have shown that low-density suspensions of self-propelled particles confined in two dimensions can assemble into finite aggregates that merge and split, but have…
We scrutinize the temporally-resolved speed of active cargo transport in living cells, and show intermittent bursting motions. These nonlinear fluctuations follow a scaling law over several decades of time and space, the statistical…
By virtue of their high galaxy space densities and their large spatial separations, clusters are efficient and accurate tracers of the large-scale density and velocity fields. Substantial progress has been made over the past decade in the…
It appears that the dynamical status of clusters and groups of galaxies is related to the large-scale structure of the Universe. A few interesting trends have been established: (1) The Cluster Substructure - Alignment Connection, by which…
Most cells possess the capacity to locomote. Alone or collectively, this allows them to adapt, to rearrange, and to explore their surroundings. The biophysical characterization of such motile processes, in health and disease, has so far…
A number of factors, such as, cell-cell interactions and self-propulsion of cells driven by cytoskeletal forces determine tissue morphologies and dynamics. To explore the interplay between these factors in controlling the dynamics at the…