Related papers: Modeling Iodine Deficiency
The thyroid gland, in conjunction with the pituitary and the hypothalamus, forms a regulated system due to their mutual influence through released hormones. The equilibrium point of this system, commonly referred to as the "set point", is…
Type 1 diabetes (T1D) is an autoimmune disorder that leads to the destruction of insulin-producing cells, resulting in insulin deficiency, as to why the affected individuals depend on external insulin injections. However, insulin can…
Iron is essential for all known life due to its redox properties, however these same properties can also lead to its toxicity in overload through the production of reactive oxygen species. Robust systemic and cellular control are required…
Thyroid hormone (TH) signalling, an evolutionary conserved pathway, is crucial for brain function and cognition throughout life, from early development to ageing. In humans, TH deficiency during pregnancy alters offspring brain development,…
Dehydration occurs when the body loses more water than it takes in. Mild dehydration can lead to fatigue, cognitive impairments, and physical complications, while severe dehydration can cause life-threatening conditions like heat stroke,…
Immunity is believed to share limited resources with other physiological functions and this may partly account for the fitness costs of reproduction. Previous studies have shown that the acquired immunity of female common eiders (Somateria…
We present a mechanistic biomathematical model of molecular radiotherapy of thyroid disease. The general model consists of a set of differential equations describing the dynamics of different populations of thyroid cells with varying…
Type 1 Diabetes (T1D) is a chronic condition where the body produces little or no insulin, a hormone required for the cells to use blood glucose (BG) for energy and to regulate BG levels in the body. Finding the right insulin dose and time…
Model-based control techniques have recently been investigated for the recommendation of medication dosages to address thyroid diseases. These techniques often rely on knowledge of internal hormone concentrations that cannot be measured…
Type 2 diabetes (T2D) is a challenging metabolic disorder characterized by a substantial loss of $\beta$-cell mass and alteration of $\beta$-cell function in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis.…
Managing Type 1 diabetes (T1D) aims to optimize glucose levels within the target range while minimizing hyperglycemia and hypoglycemia. Exercise presents additional challenges due to complex effects on glucose dynamics. Despite advancements…
Obesity and related type 2 diabetes are associated with a low level chronic inflammatory state with disease status increasing at epidemic proportions worldwide. It is now universally accepted that the underlying immune-inflammatory…
Blood glucose level monitoring is of great importance, especially for subjects experiencing type 1 diabetes. Accurate monitoring of their blood glucose level prevents dangerous and life-threatening situations that might be experienced by…
A normally functioning menstrual cycle requires significant crosstalk between hormones originating in ovarian and brain tissues. Reproductive hormone dysregulation may cause abnormal function and sometimes infertility. The inherent…
Background: Type 2 diabetes mellitus (T2DM) is increasingly recognised as a systemic disease characterised by coordinated dysfunction across metabolic, renal, lipid, and inflammatory pathways. Existing clinical assessments often fail to…
Cortical spreading depression (CSD) is a slow-moving ionic and metabolic disturbance that propagates in cortical brain tissue. In addition to massive cellular depolarization, CSD also involves significant changes in perfusion and metabolism…
Type 1 Diabetes is a chronic autoimmune condition in which the immune system attacks and destroys insulin-producing beta cells in the pancreas, resulting in little to no insulin production. Insulin helps glucose in your blood enter your…
The thyroid, an endocrine gland that secretes hormones in the blood, circulates its products to all tissues of the body, where they control vital functions in every cell. Normal levels of thyroid hormone help the brain, heart, intestines,…
Abstract The transport of nutrients or signal constituents that stimulate growth of bone tissue is supposed to be affected by a static mechanical load. It follows from basic thermodynamical principles that constituents causing volumetric…
Balancing electrolytes is utmost important and essential for appropriate functioning of organs in human body as electrolytes imbalance can be an indication of the development of underlying pathophysiology. Efficient monitoring of…