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Although Large Language Models (LLMs) have shown promising performance in healthcare-related applications, their deployment in the medical domain poses unique challenges of ethical, regulatory, and technical nature. In this study, we employ…

Computers and Society · Computer Science 2025-01-22 Giorgia Carra , Bogdan Kulynych , François Bastardot , Daniel E. Kaufmann , Noémie Boillat-Blanco , Jean Louis Raisaro

The proliferation of Large Language Models (LLMs) presents transformative potential for healthcare, yet practical deployment is hindered by the absence of frameworks that assess real-world clinical utility. Existing benchmarks test static…

Large Language Models (LLMs) have rapidly become important tools in Biomedical and Health Informatics (BHI), enabling new ways to analyze data, treat patients, and conduct research. This study aims to provide a comprehensive overview of LLM…

Digital Libraries · Computer Science 2024-07-30 Huizi Yu , Lizhou Fan , Lingyao Li , Jiayan Zhou , Zihui Ma , Lu Xian , Wenyue Hua , Sijia He , Mingyu Jin , Yongfeng Zhang , Ashvin Gandhi , Xin Ma

There is a lack of benchmarks for evaluating large language models (LLMs) in long-form medical question answering (QA). Most existing medical QA evaluation benchmarks focus on automatic metrics and multiple-choice questions. While valuable,…

Computation and Language · Computer Science 2024-11-21 Pedram Hosseini , Jessica M. Sin , Bing Ren , Bryceton G. Thomas , Elnaz Nouri , Ali Farahanchi , Saeed Hassanpour

Large Language Models (LLMs) aim to serve as versatile assistants aligned with human values, as defined by the principles of being helpful, honest, and harmless (hhh). However, in terms of Multimodal Large Language Models (MLLMs), despite…

Computer Vision and Pattern Recognition · Computer Science 2024-03-27 Zhelun Shi , Zhipin Wang , Hongxing Fan , Zaibin Zhang , Lijun Li , Yongting Zhang , Zhenfei Yin , Lu Sheng , Yu Qiao , Jing Shao

The recent rise in popularity of large language models (LLMs) has prompted considerable concerns about their moral capabilities. Although considerable effort has been dedicated to aligning LLMs with human moral values, existing benchmarks…

Artificial Intelligence · Computer Science 2025-08-19 Alessio Galatolo , Luca Alberto Rappuoli , Katie Winkle , Meriem Beloucif

Electronic Health Records (EHRs) play an important role in the healthcare system. However, their complexity and vast volume pose significant challenges to data interpretation and analysis. Recent advancements in Artificial Intelligence…

Demand for mental health support through AI chatbots is surging, though current systems present several limitations, like sycophancy or overvalidation, and reinforcement of maladaptive beliefs. A core obstacle to the creation of better…

Computation and Language · Computer Science 2025-12-08 José Pombal , Maya D'Eon , Nuno M. Guerreiro , Pedro Henrique Martins , António Farinhas , Ricardo Rei

Large language models (LLMs) are gaining increasing popularity in both academia and industry, owing to their unprecedented performance in various applications. As LLMs continue to play a vital role in both research and daily use, their…

Computation and Language · Computer Science 2024-01-01 Yupeng Chang , Xu Wang , Jindong Wang , Yuan Wu , Linyi Yang , Kaijie Zhu , Hao Chen , Xiaoyuan Yi , Cunxiang Wang , Yidong Wang , Wei Ye , Yue Zhang , Yi Chang , Philip S. Yu , Qiang Yang , Xing Xie

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to…

Computation and Language · Computer Science 2023-11-06 Mingze Yuan , Peng Bao , Jiajia Yuan , Yunhao Shen , Zifan Chen , Yi Xie , Jie Zhao , Yang Chen , Li Zhang , Lin Shen , Bin Dong

There have been rapid advancements in the capabilities of large language models (LLMs) in recent years, greatly revolutionizing the field of natural language processing (NLP) and artificial intelligence (AI) to understand and interact with…

Computation and Language · Computer Science 2024-09-26 Zeyneb N. Kaya , Souvick Ghosh

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

As medical LLMs transition to clinical deployment, assessing their ethical reasoning capability becomes critical. While achieving high accuracy on knowledge benchmarks, LLMs lack validated assessment for navigating ethical trade-offs in…

Computation and Language · Computer Science 2026-04-21 Chang Hong , Minghao Wu , Qingying Xiao , Yuchi Wang , Xiang Wan , Guangjun Yu , Benyou Wang , Yan Hu

Curated datasets for healthcare are often limited due to the need of human annotations from experts. In this paper, we present MedEval, a multi-level, multi-task, and multi-domain medical benchmark to facilitate the development of language…

Computation and Language · Computer Science 2023-11-16 Zexue He , Yu Wang , An Yan , Yao Liu , Eric Y. Chang , Amilcare Gentili , Julian McAuley , Chun-Nan Hsu

We present an ethical decision-making framework that refines a pre-trained reinforcement learning (RL) model using a task-agnostic ethical layer. Following initial training, the RL model undergoes ethical fine-tuning, where human feedback…

Computers and Society · Computer Science 2026-05-05 Rohit K. Dubey , Damian Dailisan , Sachit Mahajan

Large Language Models (LLMs) have demonstrated remarkable capabilities in modern medicine, yet their application in Traditional Chinese Medicine (TCM) remains severely limited by the absence of standardized benchmarks and the scarcity of…

Computation and Language · Computer Science 2025-12-29 Zihao Cheng , Yuheng Lu , Huaiqian Ye , Zeming Liu , Minqi Wang , Jingjing Liu , Zihan Li , Wei Fan , Yuanfang Guo , Ruiji Fu , Shifeng She , Gang Wang , Yunhong Wang

Several studies showed that Large Language Models (LLMs) can answer medical questions correctly, even outperforming the average human score in some medical exams. However, to our knowledge, no study has been conducted to assess the ability…

Computation and Language · Computer Science 2025-01-03 Asma Ben Abacha , Wen-wai Yim , Yujuan Fu , Zhaoyi Sun , Meliha Yetisgen , Fei Xia , Thomas Lin

The deployment of large language models (LLMs) within the healthcare sector has sparked both enthusiasm and apprehension. These models exhibit the remarkable capability to provide proficient responses to free-text queries, demonstrating a…

Computation and Language · Computer Science 2024-07-09 Zabir Al Nazi , Wei Peng

Large Language Models (LLMs) have demonstrated remarkable versatility in recent years, offering potential applications across specialized domains such as healthcare and medicine. Despite the availability of various open-source LLMs tailored…

Computation and Language · Computer Science 2024-07-18 Yanis Labrak , Adrien Bazoge , Emmanuel Morin , Pierre-Antoine Gourraud , Mickael Rouvier , Richard Dufour

Medicine is inherently pluralistic. Principles such as autonomy, beneficence, nonmaleficence, and justice routinely conflict, and such ethical dilemmas often sharply divide reasonable physicians. Good clinical practice navigates these…