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Reliable early detection of Alzheimer's disease (AD) is challenging, particularly due to limited availability of labeled data. While large language models (LLMs) have shown strong transfer capabilities across domains, adapting them to the…
Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…
Early diagnosis of Alzheimer's Disease (AD) is crucial for delaying its progression. While AI-based speech detection is non-invasive and cost-effective, it faces a critical data efficiency dilemma due to medical data scarcity and privacy…
Alzheimer's disease is a progressive, neurodegenerative disorder that causes memory loss and cognitive decline. While there has been extensive research in applying deep learning models to Alzheimer's prediction tasks, these models remain…
Alzheimer's disease (AD) is a growing global health challenge as populations age, and timely, accurate diagnosis is essential to reduce individual and societal burden. However, real-world AD assessment is hampered by incomplete,…
Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…
Alzheimer's disease (AD) is the fifth-leading cause of death among Americans aged 65 and older. Screening and early detection of AD and related dementias (ADRD) are critical for timely intervention and for identifying clinical trial…
We propose a novel framework for integrating fragmented multi-modal data in Alzheimer's disease (AD) research using large language models (LLMs) and knowledge graphs. While traditional multimodal analysis requires matched patient IDs across…
Synthetic clinical data are increasingly important for advancing AI in healthcare, given strict privacy constraints on real-world EHRs, limited availability of annotated rare-condition data, and systemic biases in observational datasets.…
Alzheimer's disease (AD) presents a complex, multifaceted challenge to patients, caregivers, and the healthcare system, necessitating integrated and dynamic support solutions. While artificial intelligence (AI) offers promising avenues for…
Large language models (LLMs) can generate natural language texts for various domains and tasks, but their potential for clinical text mining, a domain with scarce, sensitive, and imbalanced medical data, is underexplored. We investigate…
The ability to predict the future trajectory of a patient is a key step toward the development of therapeutics for complex diseases such as Alzheimer's disease (AD). However, most machine learning approaches developed for prediction of…
Alzheimer's disease (AD) has become one of the most significant health challenges in an aging society. The use of spoken language-based AD detection methods has gained prevalence due to their scalability due to their scalability. Based on…
Alzheimers Disease (AD) is a progressive neurodegenerative disorder that poses significant challenges in its early diagnosis, often leading to delayed treatment and poorer outcomes for patients. Traditional diagnostic methods, typically…
Alzheimer's dementia (AD) is a neurodegenerative disorder with cognitive decline that commonly impacts language ability. This work extends the paired perplexity approach to detecting AD by using a recent large language model (LLM), the…
Effective dementia caregiving requires training and adaptive communication, but assistive AI and robotics are constrained by a lack of context-rich, privacy-sensitive data on how people living with Alzheimer's disease and related dementias…
Alzheimer's disease (AD) is an irreversible brain disease that can dramatically reduce quality of life, most commonly manifesting in older adults and eventually leading to the need for full-time care. Early detection is fundamental to…
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. Early and precise diagnosis of AD is crucial for timely intervention and treatment planning to alleviate the progressive neurodegeneration. However, most…
Electroencephalography (EEG) provides a non-invasive, highly accessible, and cost-effective approach for detecting Alzheimer's disease (AD). However, existing methods, whether based on handcrafted feature engineering or standard deep…
Large language models (LLMs) have emerged as powerful tools for medical information retrieval, yet their accuracy and depth remain limited in specialized domains such as Alzheimer's disease (AD), a growing global health challenge. To…