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Localizing neuronal activity in the brain, both in time and in space, is a central challenge to advance the understanding of brain function. Because of the inability of any single neuroimaging techniques to cover all aspects at once, there…

Neurons and Cognition · Quantitative Biology 2013-07-09 Yaroslav O. Halchenko , Michael Hanke , James V. Haxby , Stephen Jose Hanson , Christoph S. Herrmann

Pathology foundation models learn morphological representations through self-supervised pretraining on large-scale whole-slide images, yet they do not explicitly capture the underlying molecular state of the tissue. Spatial transcriptomics…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Minsoo Lee , Jonghyun Kim , Juseung Yun , Sunwoo Yu , Jongseong Jang

Terahertz time-domain spectroscopy (THz-TDS) is a powerful tool for extracting optical and electrical parameters, as well as probing internal structures and surface morphology of materials. However, conventional simulation techniques, such…

Optics · Physics 2025-10-07 Pengfei Zhu , Xavier Maldague

Singing-driven 3D head animation is a challenging yet promising task with applications in virtual avatars, entertainment, and education. Unlike speech, singing involves richer emotional nuance, dynamic prosody, and lyric-based semantics,…

Graphics · Computer Science 2025-09-03 Zikai Huang , Yihan Zhou , Xuemiao Xu , Cheng Xu , Xiaofen Xing , Jing Qin , Shengfeng He

Audio-driven talking head synthesis strives to generate lifelike video portraits from provided audio. The diffusion model, recognized for its superior quality and robust generalization, has been explored for this task. However, establishing…

Multimedia · Computer Science 2024-09-17 Fa-Ting Hong , Yunfei Liu , Yu Li , Changyin Zhou , Fei Yu , Dan Xu

The entorhinal-hippocampal formation is the mammalian brain's navigation system, encoding both physical and abstract spaces via grid cells. This system is well-studied in neuroscience, and its efficiency and versatility make it attractive…

Neural and Evolutionary Computing · Computer Science 2025-03-12 Sven Krausse , Emre Neftci , Friedrich T. Sommer , Alpha Renner

Medical images used in clinical practice are heterogeneous and not the same quality as scans studied in academic research. Preprocessing breaks down in extreme cases when anatomy, artifacts, or imaging parameters are unusual or protocols…

Image and Video Processing · Electrical Eng. & Systems 2022-08-31 Mostafa Mehdipour Ghazi , Mads Nielsen

Medical image segmentation has become an essential technique in clinical and research-oriented applications. Because manual segmentation methods are tedious, and fully automatic segmentation lacks the flexibility of human intervention or…

Image and Video Processing · Electrical Eng. & Systems 2019-04-24 Kevin Karsch , Qing He , Ye Duan

Ex-vivo MRI offers invaluable insights into the complexity of the human brain, enabling high-resolution anatomical delineation and integration with histopathology, and thus, contributes to both basic and clinical studies on normal and…

Quantitative Methods · Quantitative Biology 2024-12-25 Qinfeng Zhu , Sihui Li , Zuozhen Cao , Yao Shen , Haoan Xu , Guojun Xu , Haotian Li , Keqing Zhu , Zhiyong Zhao , Jing Zhang , Dan Wu

Deep learning models usually require sufficient training data to achieve high accuracy, but obtaining labeled data can be time-consuming and labor-intensive. Here we introduce a template-based training method to train a 3D U-Net model from…

Image and Video Processing · Electrical Eng. & Systems 2023-08-07 Fang-Cheng Yeh

3D brain MRI studies often examine subtle morphometric differences between cohorts that are hard to detect visually. Given the high cost of MRI acquisition, these studies could greatly benefit from image syntheses, particularly…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Binxu Li , Wei Peng , Mingjie Li , Ehsan Adeli , Kilian M. Pohl

A brain tumour is a mass or cluster of abnormal cells in the brain, which has the possibility of becoming life-threatening because of its ability to invade neighbouring tissues and also form metastases. An accurate diagnosis is essential…

Image and Video Processing · Electrical Eng. & Systems 2022-01-28 Soumick Chatterjee , Faraz Ahmed Nizamani , Andreas Nürnberger , Oliver Speck

Synthetic biology and bioengineering provide the opportunity to create novel embodied cognitive systems (otherwise known as minds) in a very wide variety of chimeric architectures combining evolved and designed material and software. These…

Tissues and Organs · Quantitative Biology 2022-01-26 Michael Levin

In this paper, I perform mental experiment to analyze hypothetical process of mind uploading. That process suggested as a way to achieve resurrection of human consciousness. Mind uploading can be seen as a migration process of the core…

General Physics · Physics 2007-10-16 V. Astakhov

Animatable head avatar generation typically requires extensive data for training. To reduce the data requirements, a natural solution is to leverage existing data-free static avatar generation methods, such as pre-trained diffusion models…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Zhenglin Zhou , Fan Ma , Hehe Fan , Tat-Seng Chua

Recent advances in fluorescence microscopy techniques and tissue clearing, labeling, and staining provide unprecedented opportunities to investigate brain structure and function. These experiments' images make it possible to catalog brain…

The construction of brain graphs from functional Magnetic Resonance Imaging (fMRI) data plays a crucial role in enabling graph machine learning for neuroimaging. However, current practices often rely on rigid pipelines that overlook…

Machine Learning · Computer Science 2025-08-19 Qinwen Ge , Roza G. Bayrak , Anwar Said , Catie Chang , Xenofon Koutsoukos , Tyler Derr

Since its foundations, more than one hundred years ago, the field of structural biology has strived to understand and analyze the properties of molecules and their interactions by studying the structure that they take in 3D space. However,…

Biomolecules · Quantitative Biology 2023-02-27 Gabriele Corso

Recently, text-guided 3D generative methods have made remarkable advancements in producing high-quality textures and geometry, capitalizing on the proliferation of large vision-language and image diffusion models. However, existing methods…

Computer Vision and Pattern Recognition · Computer Science 2023-08-30 Xiao Han , Yukang Cao , Kai Han , Xiatian Zhu , Jiankang Deng , Yi-Zhe Song , Tao Xiang , Kwan-Yee K. Wong

In order to be widely applicable, speech-driven 3D head avatars must articulate their lips in accordance with speech, while also conveying the appropriate emotions with dynamically changing facial expressions. The key problem is that…

Graphics · Computer Science 2026-01-28 Radek Daněček , Carolin Schmitt , Senya Polikovsky , Michael J. Black