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The complexity and variability inherent in high-resolution pathological images present significant challenges in computational pathology. While pathology foundation models leveraging AI have catalyzed transformative advancements, their…

Recent advancements in foundation models have transformed computer vision, driving significant performance improvements across diverse domains, including digital histopathology. However, the advantages of domain-specific histopathology…

Computer Vision and Pattern Recognition · Computer Science 2025-02-05 Valentina Vadori , Antonella Peruffo , Jean-Marie Graïc , Livio Finos , Enrico Grisan

Recent advancements in biomedical image analysis have been significantly driven by the Segment Anything Model (SAM). This transformative technology, originally developed for general-purpose computer vision, has found rapid application in…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Ho Hin Lee , Yu Gu , Theodore Zhao , Yanbo Xu , Jianwei Yang , Naoto Usuyama , Cliff Wong , Mu Wei , Bennett A. Landman , Yuankai Huo , Alberto Santamaria-Pang , Hoifung Poon

Top-performing machine learning systems, such as deep neural networks, large ensembles and complex probabilistic graphical models, can be expensive to store, slow to evaluate and hard to integrate into larger systems. Ideally, we would like…

Machine Learning · Statistics 2015-10-09 George Papamakarios

Implicit solvent models (ISMs) promise to deliver the accuracy of explicit solvent simulations at a fraction of the computational cost. However, despite decades of development, their accuracy has remained insufficient for many critical…

Biological Physics · Physics 2026-03-26 Justin Airas , Bin Zhang

Multimodal image matching seeks pixel-level correspondences between images of different modalities, crucial for cross-modal perception, fusion and analysis. However, the significant appearance differences between modalities make this task…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Meng Yang , Fan Fan , Zizhuo Li , Songchu Deng , Yong Ma , Jiayi Ma

With the rapid development of computational pathology, many AI-assisted diagnostic tasks have emerged. Cellular nuclei segmentation can segment various types of cells for downstream analysis, but it relies on predefined categories and lacks…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Chunlin Zhong , Shuang Hao , Junhua Wu , Xiaona Chang , Jiwei Jiang , Xiu Nie , He Tang , Xiang Bai

Predicting clinical outcomes from brain networks in large-scale neuroimaging cohorts such as the Adolescent Brain Cognitive Development (ABCD) study requires effectively integrating functional connectivity (FC) and structural connectivity…

Computational Engineering, Finance, and Science · Computer Science 2026-02-11 Zhenyu Lei , Aiying Zhang , Song Wang , Han Fan , Jundong Li

The recent surge of foundation models in computer vision and natural language processing opens up perspectives in utilizing multi-modal clinical data to train large models with strong generalizability. Yet pathological image datasets often…

Computer Vision and Pattern Recognition · Computer Science 2023-07-28 Yunkun Zhang , Jin Gao , Mu Zhou , Xiaosong Wang , Yu Qiao , Shaoting Zhang , Dequan Wang

The use of artificial intelligence to enable precision medicine and decision support systems through the analysis of pathology images has the potential to revolutionize the diagnosis and treatment of cancer. Such applications will depend on…

The rapid development of diagnostic technologies in healthcare is leading to higher requirements for physicians to handle and integrate the heterogeneous, yet complementary data that are produced during routine practice. For instance, the…

Machine Learning · Computer Science 2023-01-30 Can Cui , Haichun Yang , Yaohong Wang , Shilin Zhao , Zuhayr Asad , Lori A. Coburn , Keith T. Wilson , Bennett A. Landman , Yuankai Huo

Foundation models are used to extract transferable representations from large amounts of unlabeled data, typically via self-supervised learning (SSL). However, many of these models rely on architectures that offer limited interpretability,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Samuel Ofosu Mensah , Camila Roa , Kerol Djoumessi , Philipp Berens

The limited availability of labeled data has driven advancements in semi-supervised learning for medical image segmentation. Modern large-scale models tailored for general segmentation, such as the Segment Anything Model (SAM), have…

Computer Vision and Pattern Recognition · Computer Science 2024-12-19 Kaiwen Huang , Tao Zhou , Huazhu Fu , Yizhe Zhang , Yi Zhou , Chen Gong , Dong Liang

Foundation models (FMs) are transforming computational pathology by offering new ways to analyze histopathology images. However, FMs typically require weeks of training on large databases, making their creation a resource-intensive process.…

Image and Video Processing · Electrical Eng. & Systems 2026-01-27 Till Nicke , Daniela Schacherer , Jan Raphael Schäfer , Natalia Artysh , Antje Prasse , André Homeyer , Andrea Schenk , Henning Höfener , Johannes Lotz

This paper introduces an innovative multi-modal fusion deep learning approach to overcome the drawbacks of traditional single-modal recognition techniques. These drawbacks include incomplete information and limited diagnostic accuracy.…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Xiaoyi Liu , Hongjie Qiu , Muqing Li , Zhou Yu , Yutian Yang , Yafeng Yan

To handle the large scale of whole slide images in computational pathology, most approaches first tessellate the images into smaller patches, extract features from these patches, and finally aggregate the feature vectors with…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Benedikt Roth , Valentin Koch , Sophia J. Wagner , Julia A. Schnabel , Carsten Marr , Tingying Peng

CLIP-based domain generalization aims to improve model generalization to unseen domains by leveraging the powerful zero-shot classification capabilities of CLIP and multiple source datasets. Existing methods typically train a single model…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Yuhe Ding , Jian Liang , Bo Jiang , Zi Wang , Aihua Zheng , Bin Luo

Presenting users with diverse responses from foundation models is crucial for enhancing user experience and accommodating varying preferences. However, generating multiple high-quality and diverse responses without sacrificing accuracy…

Machine Learning · Computer Science 2024-11-12 Yeming Wen , Swarat Chaudhuri

Knowledge Distillation is becoming one of the primary trends among neural network compression algorithms to improve the generalization performance of a smaller student model with guidance from a larger teacher model. This momentous rise in…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Sumanth Chennupati , Mohammad Mahdi Kamani , Zhongwei Cheng , Lin Chen

Disease progression modeling provides a robust framework to identify long-term disease trajectories from short-term biomarker data. It is a valuable tool to gain a deeper understanding of diseases with a long disease trajectory, such as…

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