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Designing novel proteins with desired characteristics remains a significant challenge due to the large sequence space and the complexity of sequence-function relationships. Efficient exploration of this space to identify sequences that meet…

Machine Learning · Computer Science 2026-03-04 Erik Hartman , Di Tang , Johan Malmström

Many problems in database systems, such as cardinality estimation, database testing and optimizer tuning, require a large query load as data. However, it is often difficult to obtain a large number of real queries from users due to user…

Databases · Computer Science 2023-03-28 Weihua Sun , Run-An Wang , Zhaonian Zou

Recently, Retrieval-Augmented Generation (RAG) has achieved remarkable success in addressing the challenges of Large Language Models (LLMs) without necessitating retraining. By referencing an external knowledge base, RAG refines LLM…

Artificial Intelligence · Computer Science 2024-09-11 Boci Peng , Yun Zhu , Yongchao Liu , Xiaohe Bo , Haizhou Shi , Chuntao Hong , Yan Zhang , Siliang Tang

Retrieval-augmented generation (RAG) is a powerful technique that enhances downstream task execution by retrieving additional information, such as knowledge, skills, and tools from external sources. Graph, by its intrinsic "nodes connected…

Retrieval-Augmented Generation (RAG) has gained significant attention in recent years for its potential to enhance natural language understanding and generation by combining large-scale retrieval systems with generative models. RAG…

Computation and Language · Computer Science 2025-03-18 Mingyue Cheng , Yucong Luo , Jie Ouyang , Qi Liu , Huijie Liu , Li Li , Shuo Yu , Bohou Zhang , Jiawei Cao , Jie Ma , Daoyu Wang , Enhong Chen

Retrieval-Augmented Generation (RAG) combines the language understanding and reasoning power of large language models (LLMs) with external retrieval to enable domain-grounded responses. Effectively adapting RAG systems to domain-specific…

Computation and Language · Computer Science 2026-04-14 Chris Xing Tian , Weihao Xie , Zhen Chen , Zhengyuan Yi , Hui Liu , Haoliang Li , Shiqi Wang , Siwei Ma

This work introduces a novel system for the generation of images that contain multiple classes of objects. Recent work in Generative Adversarial Networks have produced high quality images, but many focus on generating images of a single…

Machine Learning · Computer Science 2019-11-11 Elijah D. Bolluyt , Cristina Comaniciu

Retrieval Augmented Generation (RAG) system is important in domains such as e-commerce, which has many long-tail entities and frequently updated information. Most existing works adopt separate modules for retrieval and generation, which may…

Computation and Language · Computer Science 2024-10-01 Kaisi Guan , Qian Cao , Yuchong Sun , Xiting Wang , Ruihua Song

Kernel methods are ubiquitous tools in machine learning. However, there is often little reason for the common practice of selecting a kernel a priori. Even if a universal approximating kernel is selected, the quality of the finite sample…

Machine Learning · Statistics 2018-01-31 Junier Oliva , Avinava Dubey , Andrew G. Wilson , Barnabas Poczos , Jeff Schneider , Eric P. Xing

Proteins perform critical processes in all living systems: converting solar energy into chemical energy, replicating DNA, as the basis of highly performant materials, sensing and much more. While an incredible range of functionality has…

Biomolecules · Quantitative Biology 2021-09-29 Leonardo V. Castorina , Rokas Petrenas , Kartic Subr , Christopher W. Wood

Interacting RNA complexes are studied via bicellular maps using a filtration via their topological genus. Our main result is a new bijection for RNA-RNA interaction structures and linear time uniform sampling algorithm for RNA complexes of…

Combinatorics · Mathematics 2014-04-15 Benjamin Mingming Fu , Hillary Siwei Han , Christian M. Reidys

Prediction of human actions in social interactions has important applications in the design of social robots or artificial avatars. In this paper, we focus on a unimodal representation of interactions and propose to tackle interaction…

Neural and Evolutionary Computing · Computer Science 2022-09-13 Louis Airale , Dominique Vaufreydaz , Xavier Alameda-Pineda

Automated industrial optimization modeling requires reliable translation of natural-language requirements into solver-executable code. However, large language models often generate non-compilable models due to missing declarations, type…

Software Engineering · Computer Science 2026-03-04 Y. Zhong , R. Huang , M. Wang , Z. Guo , YC. Li , M. Yu , Z. Jin

Single-cell RNA sequencing (scRNA-seq) provides unprecedented insights into cellular heterogeneity, enabling detailed analysis of complex biological systems at single-cell resolution. However, the high dimensionality and technical noise…

Genomics · Quantitative Biology 2025-09-04 Hojjat Torabi Goudarzi , Maziyar Baran Pouyan

Incorporating prior knowledge like lexical constraints into the model's output to generate meaningful and coherent sentences has many applications in dialogue system, machine translation, image captioning, etc. However, existing RNN-based…

Computation and Language · Computer Science 2019-11-20 Dayiheng Liu , Jie Fu , Qian Qu , Jiancheng Lv

To design a drug given a biological molecule by using deep learning methods, there are many successful models published recently. People commonly used generative models to design new molecules given certain protein. LiGAN was regarded as…

Machine Learning · Computer Science 2022-11-15 Haotian Zhang , Linxiaoyi Wan

Biomedical research increasingly relies on integrating diverse data modalities, including gene expression profiles, medical images, and clinical metadata. While medical images and clinical metadata are routinely collected in clinical…

Artificial Intelligence · Computer Science 2026-01-23 Francesca Pia Panaccione , Carlo Sgaravatti , Pietro Pinoli

Retrieval-Augmented Generation (RAG) merges retrieval methods with deep learning advancements to address the static limitations of large language models (LLMs) by enabling the dynamic integration of up-to-date external information. This…

Information Retrieval · Computer Science 2026-05-19 Yizheng Huang , Jimmy Huang

Photo-acid generators (PAGs) are compounds that release acids ($H^+$ ions) when exposed to light. These compounds are critical components of the photolithography processes that are used in the manufacture of semiconductor logic and memory…

Machine Learning · Computer Science 2021-12-06 Samuel C. Hoffman , Vijil Chenthamarakshan , Dmitry Yu. Zubarev , Daniel P. Sanders , Payel Das

Neural Architecture Search (NAS) has gained widespread attention for its transformative potential in deep learning model design. However, the vast and complex search space of NAS leads to significant computational and time costs. Neural…

Neural and Evolutionary Computing · Computer Science 2025-09-30 Bingye Zhou , Caiyang Yu , Chenwei Tang
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