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Glioblastoma is the most malignant type of central nervous system tumor with GBM subtypes cleaved based on molecular level gene alterations. These alterations are also happened to affect the histology. Thus, it can cause visible changes in…

Quantitative Methods · Quantitative Biology 2020-10-28 Navodini Wijethilake , Mobarakol Islam , Dulani Meedeniya , Charith Chitraranjan , Indika Perera , Hongliang Ren

Purpose: Accurate segmentation of glioma subregions in multi-parametric MRI (MP-MRI) is essential for diagnosis and treatment planning but remains challenging due to tumor heterogeneity and ambiguous boundaries. This study proposes an…

Medical Physics · Physics 2025-07-22 Zhenyu Yang , Chen Yang , Rihui Zhang , Minbin Chen , Chunhao Wang , Fang-Fang Yin

Gliomas are the most common malignant primary brain tumors in adults and one of the deadliest types of cancer. There are many challenges in treatment and monitoring due to the genetic diversity and high intrinsic heterogeneity in…

Computer Vision and Pattern Recognition · Computer Science 2024-05-29 Maria Correia de Verdier , Rachit Saluja , Louis Gagnon , Dominic LaBella , Ujjwall Baid , Nourel Hoda Tahon , Martha Foltyn-Dumitru , Jikai Zhang , Maram Alafif , Saif Baig , Ken Chang , Gennaro D'Anna , Lisa Deptula , Diviya Gupta , Muhammad Ammar Haider , Ali Hussain , Michael Iv , Marinos Kontzialis , Paul Manning , Farzan Moodi , Teresa Nunes , Aaron Simon , Nico Sollmann , David Vu , Maruf Adewole , Jake Albrecht , Udunna Anazodo , Rongrong Chai , Verena Chung , Shahriar Faghani , Keyvan Farahani , Anahita Fathi Kazerooni , Eugenio Iglesias , Florian Kofler , Hongwei Li , Marius George Linguraru , Bjoern Menze , Ahmed W. Moawad , Yury Velichko , Benedikt Wiestler , Talissa Altes , Patil Basavasagar , Martin Bendszus , Gianluca Brugnara , Jaeyoung Cho , Yaseen Dhemesh , Brandon K. K. Fields , Filip Garrett , Jaime Gass , Lubomir Hadjiiski , Jona Hattangadi-Gluth , Christopher Hess , Jessica L. Houk , Edvin Isufi , Lester J. Layfield , George Mastorakos , John Mongan , Pierre Nedelec , Uyen Nguyen , Sebastian Oliva , Matthew W. Pease , Aditya Rastogi , Jason Sinclair , Robert X. Smith , Leo P. Sugrue , Jonathan Thacker , Igor Vidic , Javier Villanueva-Meyer , Nathan S. White , Mariam Aboian , Gian Marco Conte , Anders Dale , Mert R. Sabuncu , Tyler M. Seibert , Brent Weinberg , Aly Abayazeed , Raymond Huang , Sevcan Turk , Andreas M. Rauschecker , Nikdokht Farid , Philipp Vollmuth , Ayman Nada , Spyridon Bakas , Evan Calabrese , Jeffrey D. Rudie

According to the 2021 World Health Organization (WHO) Classification scheme for gliomas, glioma segmentation is a very important basis for diagnosis and genotype prediction. In general, 3D multimodal brain MRI is an effective diagnostic…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 Xiaoyu Shi , Shurong Chai , Yinhao Li , Jingliang Cheng , Jie Bai , Guohua Zhao , Yen-Wei Chen

Gliomas are aggressive brain tumors that require accurate imaging-based diagnosis, with segmentation playing a critical role in evaluating morphology and treatment decisions. Manual delineation of gliomas is time-consuming and prone to…

Image and Video Processing · Electrical Eng. & Systems 2025-12-02 Cecilia Diana-Albelda , Roberto Alcover-Couso , Álvaro García-Martín , Jesus Bescos , Marcos Escudero-Viñolo

Glioblastoma (GBM) is an aggressive brain tumor in which IDH mutation status is a key prognostic biomarker, but traditional testing requires invasive biopsies, emphasizing the need for non-invasive approaches. In this multi-center study, we…

Gliomas, a kind of brain tumor characterized by high mortality, present substantial diagnostic challenges in low- and middle-income countries, particularly in Sub-Saharan Africa. This paper introduces a novel approach to glioma segmentation…

This study presents a multi-faceted approach combining stereotactic biopsy with standard clinical open-craniotomy for sample collection, voxel-wise analysis of MR images, regression-based Generalized Additive Models (GAM), & whole-exome…

Radiomic models have been shown to outperform clinical data for outcome prediction in glioblastoma (GBM). However, clinical implementation is limited by lack of parameters standardization. We aimed to compare nine machine learning…

Molecular classification has transformed the management of brain tumors by enabling more accurate prognostication and personalized treatment. However, timely molecular diagnostic testing for patients with brain tumors is limited,…

Gliomas are the most common primary brain tumors, evolving from the cerebral supportive cells. For clinical follow-up, the evaluation of the preoperative tumor volume is essential. Volumetric assessment of tumor volume with manual…

Computational Engineering, Finance, and Science · Computer Science 2011-03-10 Jan Egger , Miriam H. A. Bauer , Daniela Kuhnt , Christoph Kappus , Barbara Carl , Bernd Freisleben , Christopher Nimsky

Glioblastoma (GBM) is a highly aggressive primary brain tumor with limited therapeutic options and poor prognosis. The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter is a critical molecular biomarker…

Machine Learning · Computer Science 2026-01-13 Hasan M Jamil

Segmentation is a crucial task in the medical imaging field and is often an important primary step or even a prerequisite to the analysis of medical volumes. Yet treatments such as surgery complicate the accurate delineation of regions of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-13 Heejong Kim , Leo Milecki , Mina C Moghadam , Fengbei Liu , Minh Nguyen , Eric Qiu , Abhishek Thanki , Mert R Sabuncu

Computer-aided segmentation of brain tumors from MRI data is of crucial significance to clinical decision-making in diagnosis, treatment planning, and follow-up disease monitoring. Gliomas, owing to their high malignancy and heterogeneity,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-25 MD Rashidul Islam , Bakary Gibba

Gliomas are the most common malignant brain tumourswith intrinsic heterogeneity. Accurate segmentation of gliomas and theirsub-regions on multi-parametric magnetic resonance images (mpMRI)is of great clinical importance, which defines…

Image and Video Processing · Electrical Eng. & Systems 2019-11-21 Shuo Wang , Chengliang Dai , Yuanhan Mo , Elsa Angelini , Yike Guo , Wenjia Bai

In the WHO glioma classification guidelines grade, IDH mutation and 1p19q co-deletion play a central role as they are important markers for prognosis and optimal therapy planning. Therefore, we propose a fully automatic, MRI based, 3D…

Image and Video Processing · Electrical Eng. & Systems 2020-05-26 Milan Decuyper , Stijn Bonte , Karel Deblaere , Roel Van Holen

Automated segmentation proves to be a valuable tool in precisely detecting tumors within medical images. The accurate identification and segmentation of tumor types hold paramount importance in diagnosing, monitoring, and treating highly…

Image and Video Processing · Electrical Eng. & Systems 2024-03-15 Fadillah Maani , Anees Ur Rehman Hashmi , Mariam Aljuboory , Numan Saeed , Ikboljon Sobirov , Mohammad Yaqub

The BraTS dataset contains a mixture of high-grade and low-grade gliomas, which have a rather different appearance: previous studies have shown that performance can be improved by separated training on low-grade gliomas (LGGs) and…

Image and Video Processing · Electrical Eng. & Systems 2020-12-14 Richard McKinley , Micheal Rebsamen , Katrin Daetwyler , Raphael Meier , Piotr Radojewski , Roland Wiest

Recent clinical research describes a subset of glioblastoma patients that exhibit REP prior to start of radiation therapy. Current literature has thus far described this population using clinicopathologic features. To our knowledge, this…

Accurate diagnosis of glaucoma is challenging, as early-stage changes are subtle and often lack clear structural or appearance cues. Most existing approaches rely on a single modality, such as fundus or optical coherence tomography (OCT),…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Zhiwei Wang , Yuxing Li , Meilu Zhu , Defeng He , Edmund Y. Lam