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A novel numerical technique has been proposed to solve a two-phase tumour growth model in one spatial dimension without needing to account for the boundary dynamics explicitly. The equivalence to the standard definition of a weak solution…

Numerical Analysis · Mathematics 2019-02-19 Gopikrishnan C. Remesan

Current treatment planning of patients diagnosed with a brain tumor, such as glioma, could significantly benefit by accessing the spatial distribution of tumor cell concentration. Existing diagnostic modalities, e.g. magnetic resonance…

In this study, we investigate the inverse source problem arising in bioluminescence tomography, the objective of which is to reconstruct both the support and the intensity of an internal light source from boundary measurements governed by…

Numerical Analysis · Mathematics 2025-11-25 Qianqian Wu , Rongfang Gong , Wei Gong , Ziyi Zhang , Shengfeng Zhu

We present a numerical scheme for solving an inverse problem for parameter estimation in tumor growth models for glioblastomas, a form of aggressive primary brain tumor. The growth model is a reaction-diffusion partial differential equation…

Medical Physics · Physics 2020-04-22 Shashank Subramanian , Klaudius Scheufele , Miriam Mehl , George Biros

The realm of medical image diagnosis has advanced significantly with the integration of computer-aided diagnosis and surgical systems. However, challenges persist, particularly in achieving precise image segmentation. While deep learning…

Image and Video Processing · Electrical Eng. & Systems 2023-08-24 Mutyyba Asghar , Ahmad Raza Shahid , Akhtar Jamil , Kiran Aftab , Syed Ather Enam

Pathologists routinely classify breast tumors according to recurring patterns of nuclear grades, cytoplasmic coloration, and large-scale morphological formations (i.e. streams of spindle cells, adenoid islands, etc.). The fact that there…

Tissues and Organs · Quantitative Biology 2017-04-26 David H. Nguyen

For shape optimization problems, governed by elliptic equations with Dirichlet boundary condition and random coefficients, we utilize a penalization technique to get the approximate problem. We consider that uncertainties exists in the…

Optimization and Control · Mathematics 2025-08-26 Xiaowei Pang

Automatic image segmentation becomes very crucial for tumor detection in medical image processing.In general, manual and semi automatic segmentation techniques require more time and knowledge. However these drawbacks had overcome by…

Computer Vision and Pattern Recognition · Computer Science 2016-03-09 D. Anithadevi , K. Perumal

In this paper, we investigate the tumor instability by employing both analytical and numerical techniques to validate previous results and extend the analytical findings presented in a prior study by Feng et al 2023. Building upon the…

Analysis of PDEs · Mathematics 2024-01-11 Jian-Guo Liu , Thomas Witelski , Xiaoqian Xu , Jiaqi Zhang

One of the main requirements of tumor extraction is the annotation and segmentation of tumor boundaries correctly. For this purpose, we present a threefold deep learning architecture. First classifiers are implemented with a deep…

Image and Video Processing · Electrical Eng. & Systems 2021-02-09 Shanaka Ramesh Gunasekara , H. N. T. K. Kaldera , Maheshi B. Dissanayake

Physics has played a fundamental role in medicine sciences, specially in imaging diagnostic. Currently, image reconstruction techniques are already taught in Physics courses and there is a growing interest in new potential applications. The…

Physics Education · Physics 2013-02-22 Olavo Henrique Menin , Vanessa Rolnik , Alexandre Souto Martinez

With the advanced imaging technology, digital pathology imaging of tumor tissue slides is becoming a routine clinical procedure for cancer diagnosis. This process produces massive imaging data that capture histological details in high…

Applications · Statistics 2020-12-10 Esteban Fernández Morales , Cong Zhang , Guanghua Xiao , Chul Moon , Qiwei Li

Magnetic Resonance Imaging (MRI) is an important diagnostic tool for precise detection of various pathologies. Magnetic Resonance (MR) is more preferred than Computed Tomography (CT) due to the high resolution in MR images which help in…

Computer Vision and Pattern Recognition · Computer Science 2017-11-01 Pranay Manocha , Snehal Bhasme , Tanvi Gupta , BK Panigrahi , Tapan K. Gandhi

Working within the class of piecewise constant conductivities, the inverse problem of electrical impedance tomography can be recast as a shape optimization problem where the discontinuity interface is the unknown. Using Gr\"oger's…

Optimization and Control · Mathematics 2022-01-28 Yuri Flores Albuquerque , Antoine Laurain , Kevin Sturm

We develop a mathematical and numerical framework to solve state estimation problems for applications that present variations in the shape of the spatial domain. This situation arises typically in a biomedical context where inverse problems…

Numerical Analysis · Mathematics 2023-03-14 Felipe Galarce , Damiano Lombardi , Olga Mula

Understanding the dynamics of brain tumor progression is essential for optimal treatment planning. Cast in a mathematical formulation, it is typically viewed as evaluation of a system of partial differential equations, wherein the…

Quantitative Methods · Quantitative Biology 2020-01-13 Ivan Ezhov , Jana Lipkova , Suprosanna Shit , Florian Kofler , Nore Collomb , Benjamin Lemasson , Emmanuel Barbier , Bjoern Menze

Problems with localized nonhomogeneous material properties arise frequently in many applications and are a well-known source of difficulty in numerical simulations. In certain applications (including additive manufacturing), the physics of…

Numerical Analysis · Mathematics 2020-04-22 Alex Viguerie , Silvia Bertoluzza , Ferdinando Auricchio

This article is concerned with the solution of a time-dependent shape identification problem. Specifically we consider the heat equation in a domain, which contains a time-dependent inclusion of zero temperature. The objective is to detect…

Optimization and Control · Mathematics 2019-06-17 Rahel Brügger , Helmut Harbrecht , Johannes Tausch

Recent advances in deep learning have significantly improved brain tumour segmentation techniques; however, the results still lack confidence and robustness as they solely consider image data without biophysical priors or pathological…

Image and Video Processing · Electrical Eng. & Systems 2024-10-10 Lipei Zhang , Yanqi Cheng , Lihao Liu , Carola-Bibiane Schönlieb , Angelica I Aviles-Rivero

Purpose: In this paper, we investigate a framework for interactive brain tumor segmentation which, at its core, treats the problem of interactive brain tumor segmentation as a machine learning problem. Methods: This method has an advantage…

Computer Vision and Pattern Recognition · Computer Science 2016-05-20 Mohammad Havaei , Hugo Larochelle , Philippe Poulin , Pierre-Marc Jodoin