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Machine learning (ML) has emerged as a powerful tool for accelerating the computational design and production of materials. In materials science, ML has primarily supported large-scale discovery of novel compounds using first-principles…

We present a scheme to obtain an inexpensive and reliable estimate of the uncertainty associated with the predictions of a machine-learning model of atomic and molecular properties. The scheme is based on resampling, with multiple models…

Chemical Physics · Physics 2025-10-06 Felix Musil , Michael J. Willatt , Mikhail A. Langovoy , Michele Ceriotti

The accurate prediction of chemical reaction outcomes is a major challenge in computational chemistry. Current models rely heavily on either highly specific reaction templates or template-free methods, both of which present limitations. To…

Machine Learning · Computer Science 2025-09-25 Derin Ozer , Sylvain Lamprier , Thomas Cauchy , Nicolas Gutowski , Benoit Da Mota

Predicting monomer reactivity ratios is crucial for controlling monomer sequence distribution in copolymers and their properties. Traditional experimental methods of determining reactivity ratios are time-consuming and resource-intensive,…

Chemical Physics · Physics 2025-12-24 Habibollah Safari , Mona Bavarian

This chapter is a preprint from our book by , focusing on leveraging machine learning (ML) in chemical and polyolefin manufacturing optimization. It's crafted for both novices and seasoned professionals keen on the latest ML applications in…

Machine Learning · Computer Science 2024-01-23 Niket Sharma , Y. A. Liu

Accelerating the design of materials with targeted properties is one of the key materials informatics tasks. The most common approach takes a data-driven motivation, where the underlying knowledge is incorporated in the form of…

Materials Science · Physics 2022-09-28 Shunshun Liu , Kyungtae Lee , Prasanna V. Balachandran

Stereoselective reactions (both chemical and enzymatic reactions) have been essential for origin of life, evolution, human biology and medicine. Since late 1960s, there have been numerous successes in the exciting new frontier of asymmetric…

Machine Learning · Computer Science 2021-10-13 Justin Li , Dakang Zhang , Yifei Wang , Christopher Ye , Hao Xu , Pengyu Hong

We investigate the impact of choosing regressors and molecular representations for the construction of fast machine learning (ML) models of thirteen electronic ground-state properties of organic molecules. The performance of each…

Predicting the outcome of liquid droplet collisions is an extensively studied phenomenon but the current physics based models for predicting the outcomes are poor (accuracy $\approx 43\%$). The key weakness of these models is their limited…

Machine Learning · Computer Science 2021-10-04 Arpit Agarwal

Continual Few-shot Relation Extraction (CFRE) is a practical problem that requires the model to continuously learn novel relations while avoiding forgetting old ones with few labeled training data. The primary challenges are catastrophic…

Computation and Language · Computer Science 2024-02-27 Shengkun Ma , Jiale Han , Yi Liang , Bo Cheng

In recent years, the increasing threat of devastating wildfires has underscored the need for effective prescribed fire management. Process-based computer simulations have traditionally been employed to plan prescribed fires for wildfire…

Large Language Models (LLMs) have the potential to accelerate small molecule drug design due to their ability to reason about information from diverse sources and formats. However, their practical utility remains unclear due to the lack of…

Pre-season prediction of crop production outcomes such as grain yields and N losses can provide insights to stakeholders when making decisions. Simulation models can assist in scenario planning, but their use is limited because of data…

Other Quantitative Biology · Quantitative Biology 2020-11-09 Mohsen Shahhosseini , Rafael A. Martinez-Feria , Guiping Hu , Sotirios V. Archontoulis

Large pretrained models such as GPT-3 have had tremendous impact on modern natural language processing by leveraging self-supervised learning to learn salient representations that can be used to readily finetune on a wide variety of…

Machine Learning · Computer Science 2022-09-07 Walid Ahmad , Elana Simon , Seyone Chithrananda , Gabriel Grand , Bharath Ramsundar

During reactive transport modeling, the computational cost associated with chemical reaction calculations is often 10-100 times higher than that of transport calculations. Most of these costs results from chemical equilibrium calculations…

Optimization and Control · Mathematics 2017-08-17 Allan M. M. Leal , Dmitrii A. Kulik , Martin O. Saar

Machine Learning (ML) models have, in contrast to their usefulness in molecular dynamics studies, had limited success as surrogate potentials for reaction barrier search. It is due to the scarcity of training data in relevant transition…

Chemical Physics · Physics 2022-09-02 Mathias Schreiner , Arghya Bhowmik , Tejs Vegge , Jonas Busk , Ole Winther

Machine learning (ML) has been playing important roles in drug discovery in the past years by providing (pre-)screening tools for prioritising chemical compounds to pass through wet lab experiments. One of the main ML tasks in drug…

Biomolecules · Quantitative Biology 2025-02-25 Alex G. C. de Sá , David B. Ascher

In condensed matter physics and materials science, predicting material properties necessitates understanding intricate many-body interactions. Conventional methods such as density functional theory (DFT) and molecular dynamics (MD) often…

Materials Science · Physics 2023-11-17 Lalit Yadav

Accurately predicting chemical reactions is essential for driving innovation in synthetic chemistry, with broad applications in medicine, manufacturing, and agriculture. At the same time, reaction prediction is a complex problem which can…

Machine Learning · Computer Science 2025-04-23 Ryan J. Miller , Alexander E. Dashuta , Brayden Rudisill , David Van Vranken , Pierre Baldi

Corrosion poses a significant challenge to the performance of aluminum alloys, particularly in marine environments. This study investigates the application of machine learning (ML) algorithms to predict and optimize corrosion resistance,…

Signal Processing · Electrical Eng. & Systems 2025-08-19 Farnaz Kaboudvand , Maham Khalid , Nydia Assaf , Vardaan Sahgal , Jon P. Ruffley , Brian J. McDermott