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We introduce DT-ICU, a multimodal digital twin framework for continuous risk estimation in intensive care. DT-ICU integrates variable-length clinical time series with static patient information in a unified multitask architecture, enabling…

Machine Learning · Computer Science 2026-01-13 Wen Guo

To improve the performance of Intensive Care Units (ICUs), the field of bio-statistics has developed scores which try to predict the likelihood of negative outcomes. These help evaluate the effectiveness of treatments and clinical practice,…

Machine Learning · Computer Science 2019-08-23 William Caicedo-Torres , Jairo Gutierrez

Automatic ICD coding is the task of assigning codes from the International Classification of Diseases (ICD) to medical notes. These codes describe the state of the patient and have multiple applications, e.g., computer-assisted diagnosis or…

Computation and Language · Computer Science 2021-04-15 Damian Pascual , Sandro Luck , Roger Wattenhofer

There is a growing need to understand how digital systems can support clinical decision-making, particularly as artificial intelligence (AI) models become increasingly complex and less human-interpretable. This complexity raises concerns…

Transformers-based models, such as BERT, have dramatically improved the performance for various natural language processing tasks. The clinical knowledge enriched model, namely ClinicalBERT, also achieved state-of-the-art results when…

Computation and Language · Computer Science 2022-04-18 Yikuan Li , Ramsey M. Wehbe , Faraz S. Ahmad , Hanyin Wang , Yuan Luo

Deep learning (DL) based predictive models from electronic health records (EHR) deliver impressive performance in many clinical tasks. Large training cohorts, however, are often required to achieve high accuracy, hindering the adoption of…

Computation and Language · Computer Science 2020-05-27 Laila Rasmy , Yang Xiang , Ziqian Xie , Cui Tao , Degui Zhi

The recent success of machine learning methods applied to time series collected from Intensive Care Units (ICU) exposes the lack of standardized machine learning benchmarks for developing and comparing such methods. While raw datasets, such…

Machine Learning · Computer Science 2022-01-19 Hugo Yèche , Rita Kuznetsova , Marc Zimmermann , Matthias Hüser , Xinrui Lyu , Martin Faltys , Gunnar Rätsch

Developing high-performance entity normalization algorithms that can alleviate the term variation problem is of great interest to the biomedical community. Although deep learning-based methods have been successfully applied to biomedical…

Information Retrieval · Computer Science 2019-08-12 Zongcheng Ji , Qiang Wei , Hua Xu

Intensive Care Units (ICU) require comprehensive patient data integration for enhanced clinical outcome predictions, crucial for assessing patient conditions. Recent deep learning advances have utilized patient time series data, and fusion…

Machine Learning · Computer Science 2023-11-14 Samyak Jain , Manuel Burger , Gunnar Rätsch , Rita Kuznetsova

Effective representation learning of electronic health records is a challenging task and is becoming more important as the availability of such data is becoming pervasive. The data contained in these records are irregular and contain…

Machine Learning · Computer Science 2020-05-05 Sajad Darabi , Mohammad Kachuee , Shayan Fazeli , Majid Sarrafzadeh

Clinical notes contain an abundance of important but not-readily accessible information about patients. Systems to automatically extract this information rely on large amounts of training data for which their exists limited resources to…

Computation and Language · Computer Science 2020-04-23 Andriy Mulyar , Bridget T. McInnes

Intensive Care Units (ICUs) are critical environments characterized by high-stakes monitoring and complex data management. However, current practices often rely on manual data transcription and fragmented information systems, introducing…

Human-Computer Interaction · Computer Science 2025-12-11 Yibowen Zhao , Yiming Cao , Zhiqi Shen , Juan Du , Yonghui Xu , Lizhen Cui , Cyril Leung

To improve the accessibility of smart devices and to simplify their usage, building models which understand user interfaces (UIs) and assist users to complete their tasks is critical. However, unique challenges are proposed by UI-specific…

Computer Vision and Pattern Recognition · Computer Science 2021-08-11 Chongyang Bai , Xiaoxue Zang , Ying Xu , Srinivas Sunkara , Abhinav Rastogi , Jindong Chen , Blaise Aguera y Arcas

Intensive care unit (ICU) data are highly irregular, heterogeneous, and temporally fragmented, posing challenges for generalizable clinical prediction. We present PULSE-ICU, a self-supervised foundation model that learns event-level ICU…

Machine Learning · Computer Science 2025-12-01 Sejeong Jang , Joo Heung Yoon , Hyo Kyung Lee

Early identification of intensive care patients at risk of in-hospital mortality enables timely intervention and efficient resource allocation. Despite high predictive performance, existing machine learning approaches lack transparency and…

Machine Learning · Computer Science 2025-11-21 Alexander Bakumenko , Janine Hoelscher , Hudson Smith

Intensive care units (ICU) generate long, dense and evolving streams of clinical information, where physicians must repeatedly reassess patient states under time pressure, underscoring a clear need for reliable AI decision support. Existing…

Artificial Intelligence · Computer Science 2026-05-14 Chengzhi Shen , Weixiang Shen , Tobias Susetzky , Chen , Chen , Jun Li , Yuyuan Liu , Xuepeng Zhang , Zhenyu Gong , Daniel Rueckert , Jiazhen Pan

Integrating large language models into specialized domains like healthcare presents unique challenges, including domain adaptation and limited labeled data. We introduce CU-ICU, a method for customizing unsupervised instruction-finetuned…

Computation and Language · Computer Science 2025-07-21 Teerapong Panboonyuen

The intensive care unit (ICU) is a specialized hospital space where critically ill patients receive intensive care and monitoring. Comprehensive monitoring is imperative in assessing patients conditions, in particular acuity, and ultimately…

Artificial Intelligence · Computer Science 2024-11-25 Subhash Nerella , Ziyuan Guan , Scott Siegel , Jiaqing Zhang , Ruilin Zhu , Kia Khezeli , Azra Bihorac , Parisa Rashidi

Embedding algorithms are increasingly used to represent clinical concepts in healthcare for improving machine learning tasks such as clinical phenotyping and disease prediction. Recent studies have adapted state-of-the-art bidirectional…

Machine Learning · Computer Science 2021-12-07 Chao Pang , Xinzhuo Jiang , Krishna S Kalluri , Matthew Spotnitz , RuiJun Chen , Adler Perotte , Karthik Natarajan

Clinical notes contain information about patients that goes beyond structured data like lab values and medications. However, clinical notes have been underused relative to structured data, because notes are high-dimensional and sparse. This…

Computation and Language · Computer Science 2020-12-01 Kexin Huang , Jaan Altosaar , Rajesh Ranganath
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