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Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Accurate diagnosis of skin diseases remains a significant challenge due to the complex and diverse visual features present in dermatoscopic images, often compounded by a lack of interpretability in existing purely visual diagnostic models.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Kexin Yu , Zihan Xu , Jialei Xie , Carter Adams

Visual Language Models (VLMs) achieve promising results in medical reasoning but struggle with hallucinations, vague descriptions, inconsistent logic and poor localization. To address this, we propose a agent framework named Medical Visual…

Artificial Intelligence · Computer Science 2025-10-22 Guangfu Guo , Xiaoqian Lu , Yue Feng

Multi-agent large language model (LLM) systems have emerged as a promising approach for clinical diagnosis, leveraging collaboration among agents to refine medical reasoning. However, most existing frameworks rely on single-vendor teams…

Computation and Language · Computer Science 2026-03-17 Grace Chang Yuan , Xiaoman Zhang , Sung Eun Kim , Pranav Rajpurkar

Complex medical decision-making involves cooperative workflows operated by different clinicians. Designing AI multi-agent systems can expedite and augment human-level clinical decision-making. Existing multi-agent researches primarily focus…

Artificial Intelligence · Computer Science 2025-10-14 Kaitao Chen , Mianxin Liu , Daoming Zong , Chaoyue Ding , Shaohao Rui , Yankai Jiang , Mu Zhou , Xiaosong Wang

Building trustworthy clinical AI systems requires not only accurate predictions but also transparent, biologically grounded explanations. We present \texttt{DiagnoLLM}, a hybrid framework that integrates Bayesian deconvolution, eQTL-guided…

Artificial Intelligence · Computer Science 2025-11-18 Bowen Xu , Xinyue Zeng , Jiazhen Hu , Tuo Wang , Adithya Kulkarni

The rapid progress of Large Language Models (LLMs) has given rise to a new category of autonomous AI systems, referred to as Deep Research (DR) agents. These agents are designed to tackle complex, multi-turn informational research tasks by…

Artificial Intelligence · Computer Science 2025-09-04 Yuxuan Huang , Yihang Chen , Haozheng Zhang , Kang Li , Huichi Zhou , Meng Fang , Linyi Yang , Xiaoguang Li , Lifeng Shang , Songcen Xu , Jianye Hao , Kun Shao , Jun Wang

Large language model (LLM)-based multi-agent systems have demonstrated impressive capabilities in handling complex tasks. However, the complexity of agentic behaviors makes these systems difficult to understand. When failures occur,…

Human-Computer Interaction · Computer Science 2026-02-06 Rui Sheng , Yukun Yang , Chuhan Shi , Yanna Lin , Zixin Chen , Huamin Qu , Furui Cheng

Diagnosing lung cancer typically involves physicians identifying lung nodules in Computed tomography (CT) scans and generating diagnostic reports based on their morphological features and medical expertise. Although advancements have been…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Cheng Yang , Hui Jin , Xinlei Yu , Zhipeng Wang , Yaoqun Liu , Fenglei Fan , Dajiang Lei , Gangyong Jia , Changmiao Wang , Ruiquan Ge

Large Language Models (LLMs) have demonstrated remarkable success in conversational systems by generating human-like responses. However, they can fall short, especially when required to account for personalization or specific knowledge. In…

Computation and Language · Computer Science 2025-11-12 Soyeong Jeong , Aparna Elangovan , Emine Yilmaz , Oleg Rokhlenko

Fine-tuning of Large Language Models (LLMs) has become the default practice for improving model performance on a given task. However, performance improvement comes at the cost of training on vast amounts of annotated data which could be…

Computation and Language · Computer Science 2025-04-25 Jose G. Moreno , Jesus Lovon , M'Rick Robin-Charlet , Christine Damase-Michel , Lynda Tamine

Though Large Vision-Language Models (LVLMs) are being actively explored in medicine, their ability to conduct complex real-world telemedicine consultations combining accurate diagnosis with professional dialogue remains underexplored. This…

Human-Computer Interaction · Computer Science 2025-11-12 Ivan Sviridov , Amina Miftakhova , Artemiy Tereshchenko , Galina Zubkova , Pavel Blinov , Andrey Savchenko

Modern segmentation models achieve strong predictive performance but remain largely opaque, limiting our ability to diagnose failures, understand dataset shift, or intervene in a principled manner. We introduce Med-SegLens, a model-diffing…

Computer Vision and Pattern Recognition · Computer Science 2026-02-12 Salma J. Ahmed , Emad A. Mohammed , Azam Asilian Bidgoli

Medical diagnosis assistant (MDA) aims to build an interactive diagnostic agent to sequentially inquire about symptoms for discriminating diseases. However, since the dialogue records used to build a patient simulator are collected…

Computer Vision and Pattern Recognition · Computer Science 2023-07-04 Junfan Lin , Keze Wang , Ziliang Chen , Xiaodan Liang , Liang Lin

Agentic systems offer a potential path to solve complex clinical tasks through collaboration among specialized agents, augmented by tool use and external knowledge bases. Nevertheless, for chest X-ray (CXR) interpretation, prevailing…

Multiagent Systems · Computer Science 2026-04-16 Kai Zhang , Corey D Barrett , Jangwon Kim , Lichao Sun , Tara Taghavi , Krishnaram Kenthapadi

Most existing LLM diagnoses are evaluated on static, single-turn settings where complete patient information is provided upfront, an oversimplification of real clinical practice. We study active diagnosis: the real-life clinical process of…

Large Audio Language Models (LALMs) excel at perception but struggle with complex reasoning requiring precise acoustic measurements. While external tools can extract fine-grained features like exact tempo or pitch, effective integration…

Sound · Computer Science 2026-02-17 Siqian Tong , Xuan Li , Yiwei Wang , Baolong Bi , Yujun Cai , Shenghua Liu , Yuchen He , Chengpeng Hao

Clinical Decision Support Systems (CDSS) utilize evidence-based knowledge and patient data to offer real-time recommendations, with Large Language Models (LLMs) emerging as a promising tool to generate plain-text explanations for medical…

Computation and Language · Computer Science 2023-10-04 D. Umerenkov , G. Zubkova , A. Nesterov

The development of large language models (LLMs) has brought unprecedented possibilities for artificial intelligence (AI) based medical diagnosis. However, the application perspective of LLMs in real diagnostic scenarios is still unclear…

Computation and Language · Computer Science 2024-05-21 Zhoujian Sun , Cheng Luo , Ziyi Liu , Zhengxing Huang

Large Language Models (LLMs) and multi-agent systems have shown impressive capabilities in natural language tasks but face challenges in clinical trial applications, primarily due to limited access to external knowledge. Recognizing the…

Computation and Language · Computer Science 2024-07-23 Ling Yue , Sixue Xing , Jintai Chen , Tianfan Fu