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Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

Large language models (LLMs) have made significant progress in general-purpose natural language processing tasks. However, LLMs are still facing challenges when applied to domain-specific areas like telecommunications, which demands…

Computation and Language · Computer Science 2025-05-22 Dun Yuan , Hao Zhou , Di Wu , Xue Liu , Hao Chen , Yan Xin , Jianzhong , Zhang

Retrieval Augmented Generation (RAG) is an essential agent for Large Language Model (LLM) aided Description Language (HDL) tasks, addressing the challenges of limited training data and prohibitively long prompts. However, its performance in…

Hardware Architecture · Computer Science 2026-03-10 Pingqing Zheng , Jiayin Qin , Fuqi Zhang , Niraj Chitla , Zishen Wan , Shang Wu , Yu Cao , Caiwen Ding , Yang , Zhao

Large Language Models (LLMs) have achieved impressive performance across a wide range of applications. However, they often suffer from hallucinations in knowledge-intensive domains due to their reliance on static pretraining corpora. To…

Information Retrieval · Computer Science 2026-02-10 Lihui Liu , Jiayuan Ding , Subhabrata Mukherjee , Carl J. Yang

This study applies Large Language Models (LLMs) to two foundational Electronic Health Record (EHR) data science tasks: structured data querying (using programmatic languages, Python/Pandas) and information extraction from unstructured…

Computation and Language · Computer Science 2026-01-29 Juan Jose Rubio Jan , Jack Wu , Julia Ive

In the field of Material Science, effective information retrieval systems are essential for facilitating research. Traditional Retrieval-Augmented Generation (RAG) approaches in Large Language Models (LLMs) often encounter challenges such…

Information Retrieval · Computer Science 2024-12-03 Radeen Mostafa , Mirza Nihal Baig , Mashaekh Tausif Ehsan , Jakir Hasan

Large Language Models (LLMs) have shown remarkable capabilities across various domains, yet they struggle with knowledge-intensive tasks in areas that demand factual accuracy, e.g. industrial automation and healthcare. Key limitations…

Machine Learning · Computer Science 2025-09-10 Michael Banf , Johannes Kuhn

Deploying Large Language Models (LLMs) for healthcare question answering requires robust methods to ensure accuracy and reliability. This work introduces Query-Based Retrieval Augmented Generation (QB-RAG), a framework for enhancing…

Machine Learning · Computer Science 2025-07-31 Eric Yang , Jonathan Amar , Jong Ha Lee , Bhawesh Kumar , Yugang Jia

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Retrieval-augmented generation (RAG) has shown impressive capability in providing reliable answer predictions and addressing hallucination problems. A typical RAG implementation uses powerful retrieval models to extract external information…

Information Retrieval · Computer Science 2024-11-19 Ziwei Liu , Liang Zhang , Qian Li , Jianghua Wu , Guangxu Zhu

Retrieval-Augmented Generation (RAG) integrates non-parametric knowledge into Large Language Models (LLMs), typically from unstructured texts and structured graphs. While recent progress has advanced text-based RAG to multi-turn reasoning…

Computation and Language · Computer Science 2025-12-11 Yucan Guo , Miao Su , Saiping Guan , Zihao Sun , Xiaolong Jin , Jiafeng Guo , Xueqi Cheng

Large language models (LLMs) are increasingly recognized as valuable tools across the medical environment, supporting clinical, research, and administrative workflows. However, strict privacy and network security regulations in hospital…

Computation and Language · Computer Science 2026-01-09 Seokhwan Ko , Donghyeon Lee , Jaewoo Chun , Hyungsoo Han , Junghwan Cho

This paper presents the development and evaluation of a Retrieval-Augmented Generation (RAG) system for querying the United Kingdom's National Institute for Health and Care Excellence (NICE) clinical guidelines using Large Language Models…

Large Language Models (LLMs) and Code-LLMs (CLLMs) have significantly improved code generation, but, they frequently face difficulties when dealing with challenging and complex problems. Retrieval-Augmented Generation (RAG) addresses this…

Software Engineering · Computer Science 2025-06-17 Iman Saberi , Fatemeh Fard

Document-Level Biomedical Relation Extraction (Bio-RE) aims to identify relations between biomedical entities within extensive texts, serving as a crucial subfield of biomedical text mining. Existing Bio-RE methods struggle with…

Computation and Language · Computer Science 2025-01-10 Yufei Shang , Yanrong Guo , Shijie Hao , Richang Hong

Purpose: Large Language Models (LLMs) hold significant promise for medical applications. Retrieval Augmented Generation (RAG) emerges as a promising approach for customizing domain knowledge in LLMs. This case study presents the development…

Existing domain-specific Large Language Models (LLMs) are typically developed by fine-tuning general-purposed LLMs with large-scale domain-specific corpora. However, training on large-scale corpora often fails to effectively organize domain…

Computation and Language · Computer Science 2025-02-11 Zhiqiang Liu , Chengtao Gan , Junjie Wang , Yichi Zhang , Zhongpu Bo , Mengshu Sun , Huajun Chen , Wen Zhang

Despite the impressive advancements of Large Language Models (LLMs) in generating text, they are often limited by the knowledge contained in the input and prone to producing inaccurate or hallucinated content. To tackle these issues,…

Information Retrieval · Computer Science 2024-05-29 Yu Wang , Nedim Lipka , Ruiyi Zhang , Alexa Siu , Yuying Zhao , Bo Ni , Xin Wang , Ryan Rossi , Tyler Derr

Large language models (LLMs) struggle with the factual error during inference due to the lack of sufficient training data and the most updated knowledge, leading to the hallucination problem. Retrieval-Augmented Generation (RAG) has gained…

Information Retrieval · Computer Science 2026-01-22 Zulun Zhu , Tiancheng Huang , Kai Wang , Junda Ye , Xinghe Chen , Siqiang Luo

Large Language Models (LLMs) demonstrate strong reasoning abilities but face limitations such as hallucinations and outdated knowledge. Knowledge Graph (KG)-based Retrieval-Augmented Generation (RAG) addresses these issues by grounding LLM…

Computation and Language · Computer Science 2025-03-04 Mufei Li , Siqi Miao , Pan Li