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The development of tailored materials for specific applications is an active field of research in chemistry, material science and drug discovery. The number of possible molecules that can be obtained from a set of atomic species grow…

Numerous molecular systems, including solutions, proteins, and composite materials, can be modeled using mixed-resolution representations, of which the quantum mechanics/molecular mechanics (QM/MM) approach has become the most widely used.…

Chemical Physics · Physics 2018-01-17 Anton V. Sinitskiy , Gregory A. Voth

Quantum computers hold immense potential in the field of chemistry, ushering new frontiers to solve complex many body problems that are beyond the reach of classical computers. However, noise in the current quantum hardware limits their…

Quantum Physics · Physics 2024-03-20 Chayan Patra , Sonaldeep Halder , Rahul Maitra

QMCPACK has enabled cutting-edge materials research on supercomputers for over a decade. It scales nearly ideally but has low single-node efficiency due to the physics-based abstractions using array-of-structures objects, causing…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-08-10 Amrita Mathuriya , Ye Luo , Raymond C. Clay , Anouar Benali , Luke Shulenburger , Jeongnim Kim

With the advent of exascale computing, effective load balancing in massively parallel software applications is critically important for leveraging the full potential of high performance computing systems. Load balancing is the distribution…

Quantum Physics · Physics 2025-01-30 Omer Rathore , Alastair Basden , Nicholas Chancellor , Halim Kusumaatmaja

A cardinal obstacle to performing quantum-mechanical simulations of strongly-correlated matter is that, with the theoretical tools presently available, sufficiently-accurate computations are often too expensive to be ever feasible. Here we…

Strongly Correlated Electrons · Physics 2021-02-10 John Rogers , Tsung-Han Lee , Sahar Pakdel , Wenhu Xu , Vladimir Dobrosavljević , Yong-Xin Yao , Ove Christiansen , Nicola Lanatà

We introduce fusion-based quantum computing (FBQC) - a model of universal quantum computation in which entangling measurements, called fusions, are performed on the qubits of small constant-sized entangled resource states. We introduce a…

Quantum computers must meet extremely stringent qualitative and quantitative requirements on their qubits in order to solve real-life problems. Quantum circuit fragmentation techniques divide a large quantum circuit into a number of…

Quantum Physics · Physics 2024-06-25 Saikat Basu , Arnav Das , Amit Saha , Amlan Chakrabarti , Susmita Sur-Kolay

The variational principle serves as a fundamental framework for describing equilibrium states of physical systems via the minimization or extremization of an energy-like functional. While quantum algorithms have demonstrated promising…

Quantum Physics · Physics 2025-08-26 Katsuhiro Endo , Kazuaki Z. Takahashi

The Coupled Cluster (CC) method is used to compute the electronic correlation energy in atoms and molecules and often leads to highly accurate results. However, due to its single-reference nature, standard CC in its projected form fails to…

Variational quantum algorithms (VQA) have emerged as a promising quantum alternative for solving optimization and machine learning problems using parameterized quantum circuits (PQCs). The design of these circuits influences the ability of…

Quantum Physics · Physics 2024-04-18 Alexander Benítez-Buenache , Queralt Portell-Montserrat

A significant challenge in quantum computing (QC) is developing learning models that truly align with quantum principles, as many current approaches are complex adaptations of classical frameworks. In this work, we introduce Quantum…

Over the past decade, research in quantum computing has tended to fall into one of two camps: near-term intermediate scale quantum (NISQ) and fault-tolerant quantum computing (FTQC). Yet, a growing body of work has been investigating how to…

Quantum Physics · Physics 2024-09-02 Amara Katabarwa , Katerina Gratsea , Athena Caesura , Peter D. Johnson

Neural network quantum state (NNQS) has emerged as a promising candidate for quantum many-body problems, but its practical applications are often hindered by the high cost of sampling and local energy calculation. We develop a…

Quantum Physics · Physics 2023-11-02 Yangjun Wu , Chu Guo , Yi Fan , Pengyu Zhou , Honghui Shang

The strategic demand for quantum hardware currently outpaces the availability of near-term devices, necessitating high-performance software emulators to validate novel protocols. We introduce Hyperion, a massively parallel, GPU-accelerated…

The paradigm of measurement-based quantum computing (MBQC) starts from a highly entangled resource state on which unitary operations are executed through adaptive measurements and corrections ensuring determinism. This is set in contrast to…

Quantum Physics · Physics 2023-11-29 Thierry Nicolas Kaldenbach , Matthias Heller

Digital quantum computers promise exponential speedups in performing quantum time-evolution, providing an opportunity to simulate quantum dynamics of complex systems in physics and chemistry. However, the task of extracting desired quantum…

Quantum Physics · Physics 2025-03-10 Chong Hian Chee , Daniel Leykam , Adrian M. Mak , Kishor Bharti , Dimitris G. Angelakis

Hybrid quantum-classical approaches offer potential solutions to quantum chemistry problems, yet they often manifest as constrained optimization problems. Here, we explore the interconnection between constrained optimization and generalized…

Quantum Physics · Physics 2025-03-27 Muqing Zheng , Bo Peng , Ang Li , Xiu Yang , Karol Kowalski

There is a growing consensus that large-scale, fault-tolerant quantum computing (FTQC) necessitates high-fidelity photonic interconnects to overcome the scaling limits of monolithic architectures. However, most current platforms were not…

One of the outstanding challenges in contemporary science and technology is building a quantum computer that is useful in applications. By starting from an estimate of the algorithm success rate, we can explicitly connect gate fidelity to…

Quantum Physics · Physics 2026-03-20 R. Barends , F. K. Wilhelm