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To simultaneously fit multiple-pool effects, spectrally selective 3D CEST imaging typically requires single-shot readouts to save time. However, to date, FLASH and EPI have been the primary pulse sequences used for this purpose. They suffer…

Purpose: To develop a model-based deep neural network for high-quality image reconstruction of undersampled multi-coil chemical exchange saturation transfer (CEST) data. Theory and Methods: Inspired by the variational network, the CEST…

Medical Physics · Physics 2023-05-26 Jianping Xu , Tao Zu , Yi-Cheng Hsu , Xiaoli Wang , Kannie W. Y. Chan , Yi Zhang

Purpose: To develop an automated machine-learning-based method for the discovery of rapid and quantitative chemical exchange saturation transfer (CEST) MR fingerprinting acquisition and reconstruction protocols. Methods: An MR physics…

Medical Physics · Physics 2022-02-01 Or Perlman , Bo Zhu , Moritz Zaiss , Matthew S. Rosen , Christian T. Farrar

Purpose: To develop a motion-robust and geometrically-accurate quantitative CEST approach using radial k-space sampling, locally low-rank reconstruction and neural network quantification. Methods: The acquisition schedule was generated via…

Medical Physics · Physics 2026-03-27 Ouri Cohen , Elizabeth J. Sutton , Robert J. Young , Ricardo Otazo

CEST suffers from two main problems long acquisitin times or restricted coverage as well as incoherent protocol settings. In this paper we give suggestions on how to optimise your protocol settings fro CEST and present one setting for APT…

$\textbf{Purpose}$: To develop a clinical CEST MR fingerprinting (CEST-MRF) method for brain tumor quantification using EPI acquisition and deep learning reconstruction. $\textbf{Methods}$: A CEST-MRF pulse sequence originally designed for…

Purpose: This work proposes a method for the simultaneous estimation of the exchange-dependent relaxation rate Rex and the longitudinal relaxation time T1 from a single acquisition. Methods: A novel acquisition scheme was developed that…

Purpose: To employ optimal control for the numerical design of CEST saturation pulses to maximize contrast and stability against $B_0$ inhomogeneities. Theory and Methods: We applied an optimal control framework for the design pulse shapes…

Purpose: To develop a fast magnetic resonance fingerprinting (MRF) method for quantitative chemical exchange saturation transfer (CEST) imaging. Methods: We implemented a CEST-MRF method to quantify the chemical exchange rate and volume…

Medical Physics · Physics 2024-07-17 Ouri Cohen , Shuning Huang , Michael T. McMahon , Matthew S. Rosen , Christian T. Farrar

Contrast-enhanced (CE) T1-weighted MRI is central to neuro-oncologic diagnosis but requires gadolinium-based agents, which add cost and scan time, raise environmental concerns, and may pose risks to patients. In this work, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Bastian Brandstötter , Erich Kobler

Endogenous chemical exchange saturation transfer (CEST) effects are always diluted by competing effects such as direct water proton saturation (spillover) and macromolecular magnetization transfer (MT). This leads to T2-and MT-shine-through…

Background: Magnetization transfer (MT) saturation reflects the additional saturation of the MRI signal imposed by an MT pulse and is largely driven by the saturation of the bound pool. This reduction of the bound polarization by the MT…

Medical Physics · Physics 2021-05-03 Gunther Helms , Nikolaus Weiskopf , Antoine Lutti

Electroencephalogram (EEG) decoding models for brain-computer interfaces (BCIs) struggle with cross-dataset learning and generalization due to channel layout inconsistencies, non-stationary signal distributions, and limited…

Human-Computer Interaction · Computer Science 2025-07-17 Xiaoqing Chen , Siyang Li , Dongrui Wu

Multi-slice magnetic resonance images of the fetal brain are usually contaminated by severe and arbitrary fetal and maternal motion. Hence, stable and robust motion correction is necessary to reconstruct high-resolution 3D fetal brain…

Image and Video Processing · Electrical Eng. & Systems 2022-09-23 Wen Shi , Haoan Xu , Cong Sun , Jiwei Sun , Yamin Li , Xinyi Xu , Tianshu Zheng , Yi Zhang , Guangbin Wang , Dan Wu

Purpose: To understand the influence of various acquisition parameters on the ability of CEST MR-Fingerprinting (MRF) to discriminate different chemical exchange parameters and to provide tools for optimal acquisition schedule design and…

Medical Physics · Physics 2019-11-04 Or Perlman , Kai Herz , Moritz Zaiss , Ouri Cohen , Matthew S. Rosen , Christian T. Farrar

Purpose: To evaluate an algorithm for calibrationless parallel imaging to reconstruct undersampled parallel transmit field maps for the body and brain. Methods: Using synthetic data, body, and brain measurements of relative transmit maps,…

Image and Video Processing · Electrical Eng. & Systems 2020-11-13 Aaron T Hess , Iulius Dragonu , Mark Chiew

Whole-brain proton magnetic resonance spectroscopic imaging (1H-MRSI) is a non-invasive technique for assessing neurochemical distribution in the brain, offering valuable insights into brain functions and neural diseases. It greatly…

Medical Physics · Physics 2024-10-08 Zhiwei Huang , Uzay Emir , Andre Doring , Antoine Klauser , Ying Xiao , Mark Widmaier , Lijing Xin

Purpose: B1+ and T1 corrections and dynamic multi-coil shimming approaches were proposed to improve the fidelity of high isotropic resolution Generalized slice dithered enhanced resolution (gSlider) diffusion imaging. Methods: An extended…

Recent advancements in learning techniques that employ coordinate-based neural representations have yielded remarkable results in multi-view 3D reconstruction tasks. However, these approaches often require a substantial number of input…

Computer Vision and Pattern Recognition · Computer Science 2025-02-12 Pol Caselles , Eduard Ramon , Jaime Garcia , Gil Triginer , Francesc Moreno-Noguer

Purpose: To introduce a combined machine learning (ML) and physics-based image reconstruction framework that enables navigator-free, highly accelerated multishot echo planar imaging (msEPI), and demonstrate its application in…

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