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To fully expedite AI-powered chemical research, high-quality chemical databases are the foundation. Automatic extraction of chemical information from the literature is essential for constructing reaction databases, but it is currently…

Artificial Intelligence · Computer Science 2026-03-09 Yufan Chen , Ching Ting Leung , Bowen Yu , Jianwei Sun , Yong Huang , Linyan Li , Hao Chen , Hanyu Gao

The extraction of molecular structures and reaction data from scientific documents is challenging due to their varied, unstructured chemical formats and complex document layouts. To address this, we introduce MolMole, a vision-based deep…

Modern computational chemistry has reached a stage at which massive exploration into chemical reaction space with unprecedented resolution with respect to the number of potentially relevant molecular structures has become possible. Various…

Chemical Physics · Physics 2020-04-27 Jan P. Unsleber , Markus Reiher

There is increasing adoption of artificial intelligence in drug discovery. However, existing studies use machine learning to mainly utilize the chemical structures of molecules but ignore the vast textual knowledge available in chemistry.…

Machine Learning · Computer Science 2024-01-31 Shengchao Liu , Weili Nie , Chengpeng Wang , Jiarui Lu , Zhuoran Qiao , Ling Liu , Jian Tang , Chaowei Xiao , Anima Anandkumar

In this paper, we describe a multi-modal search system designed to search old archaeological books and reports. This corpus is digitally available as scanned PDFs, but varies widely in the quality of scans. Our pipeline, designed for…

In the real world, where information is abundant and diverse across different modalities, understanding and utilizing various data types to improve retrieval systems is a key focus of research. Multimodal composite retrieval integrates…

Computer Vision and Pattern Recognition · Computer Science 2024-09-12 Suyan Li , Fuxiang Huang , Lei Zhang

Information Retrieval (IR) methods aim to identify documents relevant to a query, which have been widely applied in various natural language tasks. However, existing approaches typically consider only the textual content within documents,…

Computation and Language · Computer Science 2026-01-26 Jaewoo Lee , Joonho Ko , Jinheon Baek , Soyeong Jeong , Sung Ju Hwang

To retrieve and compare scientific data of simulations and experiments in materials science, data needs to be easily accessible and machine readable to qualify and quantify various materials science phenomena. The recent progress in open…

Materials Science · Physics 2025-03-25 Balduin Katzer , Steffen Klinder , Katrin Schulz

Information extraction from chemistry literature is vital for constructing up-to-date reaction databases for data-driven chemistry. Complete extraction requires combining information across text, tables, and figures, whereas prior work has…

Machine Learning · Computer Science 2024-04-03 Vincent Fan , Yujie Qian , Alex Wang , Amber Wang , Connor W. Coley , Regina Barzilay

Multimodal vector search offers a new paradigm for information retrieval by exposing numerous pieces of functionality which are not possible in traditional lexical search engines. While multimodal vector search can be treated as a drop in…

Information Retrieval · Computer Science 2024-09-19 Owen Pendrigh Elliott , Tom Hamer , Jesse Clark

Artificial intelligence (AI) has demonstrated significant promise in advancing organic chemistry research; however, its effectiveness depends on the availability of high-quality chemical reaction data. Currently, most published chemical…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Yufan Chen , Ching Ting Leung , Jianwei Sun , Yong Huang , Linyan Li , Hao Chen , Hanyu Gao

Fueled by advances in hardware and algorithm design, large-scale automated explorations of chemical reaction space have become possible. Here, we present our approach to an open-source, extensible framework for explorations of chemical…

Chemical Physics · Physics 2022-08-30 Jan P. Unsleber , Stephanie A. Grimmel , Markus Reiher

Automated and high-throughput quantum chemical investigations into chemical processes have become feasible in great detail and broad scope. This results in an increase in complexity of the tasks and in the amount of generated data. An…

Large Language Models (LLMs) have achieved remarkable success and have been applied across various scientific fields, including chemistry. However, many chemical tasks require the processing of visual information, which cannot be…

In Information Retrieval (IR), whether implicitly or explicitly, queries and documents are often represented as vectors. However, it may be more beneficial to consider documents and/or queries as multidimensional objects. Our belief is this…

Information Retrieval · Computer Science 2010-02-18 Benjamin Piwowarski , Ingo Frommholz , Mounia Lalmas , Keith van Rijsbergen

Parsing chemical reaction diagrams from scientific literature is challenging due to heterogeneous layouts, intertwined visual elements, and the difficulty of integrating recognition and reasoning. Existing vision-language models advance…

Artificial Intelligence · Computer Science 2026-05-28 Chuang Tang , Chenhao Lin , Yin Xu , Hao Wang , Jinrui Zhou , Xin Li , Mingjun Xiao , Enhong Chen

Elucidating chemical reactivity in complex molecular assemblies of a few hundred atoms is, despite the remarkable progress in quantum chemistry, still a major challenge. Black-box search methods to find intermediates and transition-state…

Chemical Physics · Physics 2014-10-16 Moritz P. Haag , Alain C. Vaucher , Mael Bosson , Stephane Redon , Markus Reiher

This paper focuses on using natural language descriptions to enhance predictive models in the chemistry field. Conventionally, chemoinformatics models are trained with extensive structured data manually extracted from the literature. In…

Computation and Language · Computer Science 2023-12-11 Yujie Qian , Zhening Li , Zhengkai Tu , Connor W. Coley , Regina Barzilay

Due to the intrinsic complexity and nonlinearity of chemical reactions, direct applications of traditional machine learning algorithms may face with many difficulties. In this study, through two concrete examples with biological background,…

Molecular Networks · Quantitative Biology 2020-06-02 Wuyue Yang , Liangrong Peng , Yi Zhu , Liu Hong

Disentangling the mechanistic details of a chemical reaction pathway is a hard problem that often requires a considerable amount of chemical intuition and a component of luck. Experiments struggle in observing short-life metastable…

Chemical Physics · Physics 2019-08-01 Valerio Rizzi , Dan Mendels , Emilia Sicilia , Michele Parrinello
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