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Powerful array-based single-nucleotide polymorphism--typing platforms have recently heralded a new era in which genome-wide studies are conducted with increasing frequency. A genetic polymorphism associated with population pharmacokinetics…

Methodology · Statistics 2018-05-15 Kengo Nagashima , Yasunori Sato , Hisashi Noma , Chikuma Hamada

In this paper, we present a generalized estimating equations based estimation approach and a variable selection procedure for single-index models when the observed data are clustered. Unlike the case of independent observations,…

Methodology · Statistics 2011-08-08 Peng Lai , Qihua Wang , Heng Lian

In this study, we propose a family of correlation structures for crossover designs with repeated measures for both, Gaussian and non-Gaussian responses using generalized estimating equations (GEE). The structure considers two matrices: one…

Methodology · Statistics 2023-01-11 N. A. Cruz , O. O. Melo , C. A. Martinez

Extending generalized estimating equations (GEE) to ordinal response data requires a conversion of the ordinal response to a vector of binary category indicators. That leads to a rather complicated association structure, and the…

Methodology · Statistics 2017-05-23 Aristidis K. Nikoloulopoulos

Causal effect estimation (CEE) provides a crucial tool for predicting the unobserved counterfactual outcome for an entity. As CEE relaxes the requirement for ``perfect'' counterfactual samples (e.g., patients with identical attributes and…

Machine Learning · Computer Science 2024-11-19 Hechuan Wen , Tong Chen , Guanhua Ye , Li Kheng Chai , Shazia Sadiq , Hongzhi Yin

In this paper, we consider the partially linear single-index models with longitudinal data. To deal with the variable selection problem in this context, we propose a penalized procedure combined with two bias correction methods, resulting…

Methodology · Statistics 2014-02-10 Gaorong Li , Peng Lai , Heng Lian

We consider efficient estimation of the Euclidean parameters in a generalized partially linear additive models for longitudinal/clustered data when multiple covariates need to be modeled nonparametrically, and propose an estimation…

Statistics Theory · Mathematics 2014-02-05 Guang Cheng , Lan Zhou , Jianhua Z. Huang

Mixture of Experts (MoE) models constitute a widely utilized class of ensemble learning approaches in statistics and machine learning, known for their flexibility and computational efficiency. They have become integral components in…

Machine Learning · Statistics 2025-05-26 Tuan Thai , TrungTin Nguyen , Dat Do , Nhat Ho , Christopher Drovandi

Estimation of value in policy gradient methods is a fundamental problem. Generalized Advantage Estimation (GAE) is an exponentially-weighted estimator of an advantage function similar to $\lambda$-return. It substantially reduces the…

Machine Learning · Computer Science 2023-01-27 Xiulei Song , Yizhao Jin , Greg Slabaugh , Simon Lucas

Gaussian elimination (GE) is the archetypal direct algorithm for solving linear systems of equations and this has been its primary application for thousands of years. In the last decade, GE has found another major use as an iterative…

Numerical Analysis · Mathematics 2016-02-23 Alex Townsend

Many applications involve estimating the mean of multiple binomial outcomes as a common problem -- assessing intergenerational mobility of census tracts, estimating prevalence of infectious diseases across countries, and measuring…

Econometrics · Economics 2026-01-01 Yan Chen , Lihua Lei

Score matching is an estimation procedure that has been developed for statistical models whose probability density function is known up to proportionality but whose normalizing constant is intractable, so that maximum likelihood is…

Methodology · Statistics 2024-04-23 Jiazhen Xu , Janice L. Scealy , Andrew T. A. Wood , Tao Zou

Gaussian process (GP) covariance function is proposed as a matching tool in GPMatch within a full Bayesian framework under relatively weaker causal assumptions. The matching is accomplished by utilizing GP prior covariance function to…

Methodology · Statistics 2019-03-18 Bin Huang , Chen Chen , Jinzhong Liu

Estimating the generalization error (GE) of machine learning models is fundamental, with resampling methods being the most common approach. However, in non-standard settings, particularly those where observations are not independently and…

Generalized Advantage Estimation (GAE) has been used to mitigate the computational complexity of reinforcement learning (RL) by employing an exponentially weighted estimation of the advantage function to reduce the variance in policy…

Machine Learning · Computer Science 2025-07-24 Shahil Shaik , Jonathon M. Smereka , Yue Wang

Outcome-dependent sampling designs are extensively utilized in various scientific disciplines, including epidemiology, ecology, and economics, with retrospective case-control studies being specific examples of such designs. Additionally, if…

Methodology · Statistics 2023-09-22 Min Zeng , Zeyang Jia , Zijian Sui , Jinfeng Xu , Hong Zhang

Interactions between genes and environmental factors may play a key role in the etiology of many common disorders. Several regularized generalized linear models (GLMs) have been proposed for hierarchical selection of gene by environment…

Methodology · Statistics 2023-12-22 Julien St-Pierre , Karim Oualkacha , Julien St-Pierre

Large-scale precision matrix estimation is of fundamental importance yet challenging in many contemporary applications for recovering Gaussian graphical models. In this paper, we suggest a new approach of innovated scalable efficient…

Methodology · Statistics 2016-05-12 Yingying Fan , Jinchi Lv

Gaussian graphical models are used throughout the natural sciences, social sciences, and economics to model the statistical relationships between variables of interest in the form of a graph. We here provide a pedagogic introduction to…

Statistics Theory · Mathematics 2017-07-17 Caroline Uhler

We present a personalized and reliable prediction model for healthcare, which can provide individually tailored medical services such as diagnosis, disease treatment, and prevention. Our proposed framework targets at making personalized and…

Machine Learning · Statistics 2019-11-26 Ingyo Chung , Saehoon Kim , Juho Lee , Kwang Joon Kim , Sung Ju Hwang , Eunho Yang