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Machine learning algorithms have been successfully used to approximate nonlinear maps under weak assumptions on the structure and properties of the maps. We present deep neural networks using dense and convolutional layers to solve an…

Machine Learning · Statistics 2021-05-05 Johann Rudi , Julie Bessac , Amanda Lenzi

The FitzHugh-Nagumo (FHN) model, from computational neuroscience, has attracted attention in nonlinear dynamics studies as it describes the behavior of excitable systems and exhibits interesting bifurcation properties. The accurate…

Pattern Formation and Solitons · Physics 2021-02-09 Shady E. Ahmed , Omer San , Sivaramakrishnan Lakshmivarahan

The stochastic FitzHugh-Nagumo (FHN) model is a two-dimensional nonlinear stochastic differential equation with additive degenerate noise, whose first component, the only one observed, describes the membrane voltage evolution of a single…

Computation · Statistics 2024-10-08 Adeline Samson , Massimiliano Tamborrino , Irene Tubikanec

We investigate the use of neural networks (NNs) for the estimation of hidden model parameters and uncertainty quantification from noisy observational data for inverse parameter estimation problems. We formulate the parameter estimation as a…

Numerical Analysis · Mathematics 2025-10-17 German Villalobos , Johann Rudi , Andreas Mang

The use of high-frequency currents in neurostimulation has received increased attention in recent years due to its varied effects on tissues and cells. Nonlinear differential equations are commonly used as models for Neurons, and averaging…

Analysis of PDEs · Mathematics 2025-12-29 Eduardo Cerpa , Matías Courdurier , Esteban Hernández , Leonel E. Medina , Esteban Paduro

Being an example for a relaxation oscillator, the FitzHugh-Nagumo model has been widely employed for describing the generation of action potentials. In this paper, we begin with a biological interpretation of what the subsequent…

Numerical Analysis · Mathematics 2025-01-31 Burcu Gürbüz , Aytül Gökçe , Mahmut Modanlı

Demystifying effective connectivity among neuronal populations has become the trend to understand the brain mechanisms of Parkinson's disease, schizophrenia, mild traumatic brain injury, and many other unlisted neurological diseases.…

Quantitative Methods · Quantitative Biology 2019-09-27 Po-Ya Hsu

The Hodgkin and Huxley (H-H) model is a nonlinear system of four equations that describes how action potentials in neurons are initiated and propagated, and represents a major advance in the understanding of nerve cells. However, some of…

Numerical Analysis · Mathematics 2019-03-26 Jemy A. Mandujano Valle , Alexandre L. Madureira

A new mathematical model of neural networks described by diffusive FitzHugh-Nagumo equations with memristors and linear synaptic coupling is proposed and investigated. The existence of absorbing set for the solution semiflow in the energy…

Analysis of PDEs · Mathematics 2023-08-09 Yuncheng You , Jing Tian , Junyi Tu

Splitting algorithms are well-established in convex optimization and are designed to solve large-scale problems. Using such algorithms to simulate the behavior of nonlinear circuit networks provides scalable methods for the simulation and…

Systems and Control · Electrical Eng. & Systems 2025-05-26 Amir Shahhosseini , Thomas Chaffey , Rodolphe Sepulchre

Neurons are the central biological objects in understanding how the brain works. The famous Hodgkin-Huxley model, which describes how action potentials of a neuron are initiated and propagated, consists of four coupled nonlinear…

Neurons and Cognition · Quantitative Biology 2010-02-01 William Hanan , Dhagash Mehta , Guillaume Moroz , Sepanda Pouryahya

In this work, we extend the Equilibrium Propagation framework to skew-gradient systems and show an equivalence between deep Energy-Based Models and Hamiltonian neural networks. We focus on networks of diffusively coupled Fitzhugh-Nagumo…

Machine Learning · Computer Science 2026-05-22 Jack Kendall

Electroencephalography (EEG) is extensively employed in medical diagnostics and brain-computer interface (BCI) applications due to its non-invasive nature and high temporal resolution. However, EEG analysis faces significant challenges,…

Artificial Intelligence · Computer Science 2025-12-05 Zhenyu Xia , Xinlei Huang , Yuantong Gu , Suvash C. Saha

In this paper we show the possibility of creating and identifying the features of an artificial neural network (ANN) which consists of mathematical models of biological neurons. The FitzHugh--Nagumo (FHN) system is used as an example of…

Neural and Evolutionary Computing · Computer Science 2023-07-24 Tatyana Bogatenko , Konstantin Sergeev , Andrei Slepnev , Jürgen Kurths , Nadezhda Semenova

Despite rapid progress in live-imaging techniques, many complex biophysical and biochemical systems remain only partially observable, thus posing the challenge to identify valid theoretical models and estimate their parameters from an…

Biological Physics · Physics 2023-09-21 George Stepaniants , Alasdair D. Hastewell , Dominic J. Skinner , Jan F. Totz , Jörn Dunkel

Traditionally, parameter estimation in biophysical neuron and neural network models usually adopts a global search algorithm, often combined with a local search method in order to minimize the value of a cost function, which measures the…

Quantitative Methods · Quantitative Biology 2012-03-05 Dimitrios V. Vavoulis , Volko A. Straub , John A. D. Aston , Jianfeng Feng

The FitzHugh-Nagumo equation, originally conceived in neuroscience during the 1960s, became a key model providing a simplified view of excitable neuron cell behavior. Its applicability, however, extends beyond neuroscience into fields like…

Pattern Formation and Solitons · Physics 2025-01-08 Daniel Cebrián-Lacasa , Pedro Parra-Rivas , Daniel Ruiz-Reynés , Lendert Gelens

This paper focuses on the identification of dynamical systems with tailor-made model structures, where neural networks are used to approximate uncertain components and domain knowledge is retained, if available. These model structures are…

Machine Learning · Computer Science 2021-10-29 Marco Forgione , Dario Piga

We consider a class of systems with time-varying parameters, which are written as linear regressions with bounded disturbances. The task is to estimate such parameters under the condition that the regressor is finitely exciting (FE).…

Systems and Control · Electrical Eng. & Systems 2021-11-24 Anton Glushchenko , Konstantin Lastochkin

In this work a new mathematical model for complex neural networks is presented by the partly diffusive FitzHugh-Nagumo equations with ensemble boundary coupling. We analyze the dissipative dynamics and boundary coupling dynamics of the…

Analysis of PDEs · Mathematics 2020-06-01 Leslaw Skrzypek , Yuncheng You
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