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Flow-based generative models have shown remarkable success in text-to-image generation, yet fine-tuning them with intermediate feedback remains challenging, especially for continuous-time flow matching models. Most existing approaches…

Machine Learning · Computer Science 2025-10-22 Jiajun Fan , Chaoran Cheng , Shuaike Shen , Xiangxin Zhou , Ge Liu

Iterative generative models such as Flow Matching and Diffusion models have demonstrated strong test-time scaling behavior, where additional inference computation can improve generation quality. In contrast, Drift Models offer efficient…

Machine Learning · Computer Science 2026-05-19 Chenrui Ma , Xi Xiao , Lin Zhao , Tianyang Wang , Ferdinando Fioretto , Yanning Shen

We introduce OmniFlow, a novel generative model designed for any-to-any generation tasks such as text-to-image, text-to-audio, and audio-to-image synthesis. OmniFlow advances the rectified flow (RF) framework used in text-to-image models to…

Density functional theory (DFT) is a fundamental method for simulating quantum chemical properties, but it remains expensive due to the iterative self-consistent field (SCF) process required to solve the Kohn-Sham equations. Recently, deep…

Computational Physics · Physics 2025-10-23 Seongsu Kim , Nayoung Kim , Dongwoo Kim , Sungsoo Ahn

Continuous-time event sequences, in which events occur at irregular intervals, are ubiquitous across a wide range of industrial and scientific domains. The contemporary modeling paradigm is to treat such data as realizations of a temporal…

Machine Learning · Computer Science 2026-04-07 Gavin Kerrigan , Kai Nelson , Padhraic Smyth

The multi-step denoising process in diffusion and Flow Matching models causes major efficiency issues, which motivates research on few-step generation. We present Solution Flow Models (SoFlow), a framework for one-step generation from…

Machine Learning · Computer Science 2026-03-03 Tianze Luo , Haotian Yuan , Zhuang Liu

Diffusion models and flow matching have demonstrated remarkable success in text-to-image generation. While many existing alignment methods primarily focus on fine-tuning pre-trained generative models to maximize a given reward function,…

Machine Learning · Statistics 2026-02-03 Yidong Ouyang , Liyan Xie , Hongyuan Zha , Guang Cheng

Deep generative models have made rapid progress in image, text, audio, and video generation, and are increasingly being applied to structured records. For tabular data, however, generative modeling remains difficult: a dataset may contain…

Machine Learning · Computer Science 2026-05-25 Zhong Li , Qi Huang , Lincen Yang , Jiayang Shi , Zhao Yang , Niki van Stein , Thomas Bäck , Matthijs van Leeuwen

3D human reaction generation faces three main challenges:(1) high motion fidelity, (2) real-time inference, and (3) autoregressive adaptability for online scenarios. Existing methods fail to meet all three simultaneously. We propose…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Zichen Geng , Zeeshan Hayder , Wei Liu , Hesheng Wang , Ajmal Mian

Statistical shape modeling (SSM) is central to population level analysis of anatomical variability, yet most existing approaches rely on densely annotated segmentations and fixed latent representations. These requirements limit scalability…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Mokshagna Sai Teja Karanam , Tushar Kataria , Shireen Elhabian

Flow-based generative models have highly desirable properties like exact log-likelihood evaluation and exact latent-variable inference, however they are still in their infancy and have not received as much attention as alternative…

Computer Vision and Pattern Recognition · Computer Science 2020-04-06 Albert Pumarola , Stefan Popov , Francesc Moreno-Noguer , Vittorio Ferrari

Flow-based models have proven successful for time-series generation, particularly when defined in lower-dimensional latent spaces that enable efficient sampling. However, how to design latent representations with desirable equivariance…

Machine Learning · Computer Science 2026-02-02 Camilo Carvajal Reyes , Felipe Tobar

Generative AI promises to allow people to create high-quality personalized media. Although powerful, we identify three fundamental design problems with existing tooling through a literature review. We introduce a multimodal generative AI…

Human-Computer Interaction · Computer Science 2025-06-23 Gregory Croisdale , Emily Huang , John Joon Young Chung , Anhong Guo , Xu Wang , Austin Z. Henley , Cyrus Omar

Generative modeling techniques such as Diffusion and Flow Matching have achieved significant successes in generating designable and diverse protein backbones. However, many current models are computationally expensive, requiring hundreds or…

Biomolecules · Quantitative Biology 2025-10-30 Junhua Chen , Simon Mathis , Charles Harris , Kieran Didi , Pietro Lio

Investigating conformational landscapes of proteins is a crucial way to understand their biological functions and properties. AlphaFlow stands out as a sequence-conditioned generative model that introduces flexibility into structure…

Machine Learning · Computer Science 2024-07-18 Shaoning Li , Mingyu Li , Yusong Wang , Xinheng He , Nanning Zheng , Jian Zhang , Pheng-Ann Heng

This study presents a generative optimization framework that builds on a fine-tuned diffusion model and reward-directed sampling to generate high-performance engineering designs. The framework adopts a parametric representation of the…

Machine Learning · Computer Science 2025-08-05 Hadi Keramati , Patrick Kirchen , Mohammed Hannan , Rajeev K. Jaiman

Data scarcity and weak supervision continue to limit the performance of machine learning models in many real-world applications, such as mammography, where Multiple Instance Learning (MIL) often offers the best formulation. While recent…

Machine Learning · Computer Science 2026-04-21 Nikola Jovišić , Milica Škipina , Vanja Švenda

Navigating the vast chemical space of druggable compounds is a formidable challenge in drug discovery, where generative models are increasingly employed to identify viable candidates. Conditional 3D structure-based drug design (3D-SBDD)…

Machine Learning · Computer Science 2025-02-04 Kiwoong Yoo , Owen Oertell , Junhyun Lee , Sanghoon Lee , Jaewoo Kang

Graph generation has emerged as a critical task in fields ranging from drug discovery to circuit design. Contemporary approaches, notably diffusion and flow-based models, have achieved solid graph generative performance through constructing…

Machine Learning · Computer Science 2026-03-06 Keyue Jiang , Jiahao Cui , Xiaowen Dong , Laura Toni

Chip placement plays an important role in physical design. While generative models like diffusion models offer promising learning-based solutions, current methods have the following limitations: they use random synthetic data for…

Hardware Architecture · Computer Science 2026-04-28 Peng Xie , Ke Xue , Yunqi Shi , Ruo-Tong Chen , Chengrui Gao , Siyuan Xu , Chenjian Ding , Mingxuan Yuan , Chao Qian