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We present design and implementation of a novel neural network potential (NNP) and its combination with an electrostatic embedding scheme, commonly used within the context of hybrid quantum-mechanical/molecular-mechanical (QM/MM)…

Chemical Physics · Physics 2025-08-15 Felix Pultar , Moritz Thuerlemann , Igor Gordiy , Eva Doloszeski , Sereina Riniker

The construction of a reaction network containing all relevant intermediates and elementary reactions is necessary for the accurate description of chemical processes. In the case of a complex chemical reaction (involving, for instance, many…

Chemical Physics · Physics 2017-12-19 Gregor N. Simm , Markus Reiher

Network representation learning has aroused widespread interests in recent years. While most of the existing methods deal with edges as pairwise relationships, only a few studies have been proposed for hyper-networks to capture more…

Social and Information Networks · Computer Science 2019-10-23 Jie Huang , Xin Liu , Yangqiu Song

The interaction of neural networks with physical equations offers a wide range of applications. We provide a method which enables a neural network to transform objects subject to given physical constraints. Therefore an U-Net architecture…

Artificial Intelligence · Computer Science 2021-03-22 Lukas Harsch , Johannes Burgbacher , Stefan Riedelbauch

We present an elaborate framework for formally modelling pathways in chemical reaction networks on a mechanistic level. Networks are modelled mathematically as directed multi-hypergraphs, with vertices corresponding to molecules and…

Molecular Networks · Quantitative Biology 2017-12-08 Jakob L. Andersen , Christoph Flamm , Daniel Merkle , Peter F. Stadler

Neural Radiance Field (NeRF) has emerged as a compelling method to represent 3D objects and scenes for photo-realistic rendering. However, its implicit representation causes difficulty in manipulating the models like the explicit mesh…

Computer Vision and Pattern Recognition · Computer Science 2022-10-14 Jiaxiang Tang , Xiaokang Chen , Jingbo Wang , Gang Zeng

We introduce Neural Radiosity, an algorithm to solve the rendering equation by minimizing the norm of its residual similar as in traditional radiosity techniques. Traditional basis functions used in radiosity techniques, such as piecewise…

Graphics · Computer Science 2021-10-12 Saeed Hadadan , Shuhong Chen , Matthias Zwicker

Message passing neural networks have become a method of choice for learning on graphs, in particular the prediction of chemical properties and the acceleration of molecular dynamics studies. While they readily scale to large training data…

Machine Learning · Computer Science 2021-06-08 Kristof T. Schütt , Oliver T. Unke , Michael Gastegger

In reaction path optimization, such as the calculation of a minimum energy path (MEP) between given reactant and product configurations of atoms, it is advantageous to start with an initial guess where close proximity of atoms is avoided…

Chemical Physics · Physics 2023-10-10 Yorick L. A. Schmerwitz , Vilhjálmur Ásgeirsson , Hannes Jónsson

Mapping reaction pathways and transition states (TS) is fundamental to chemistry but computationally expensive at scale. The minimum energy pathway (MEP) dictates reaction rates and mechanisms, yet recovering it via electronic-structure…

Chemical Physics · Physics 2026-05-25 Rémi Schlama , Philippe Schwaller

Recurrent neural networks have seen widespread use in modeling dynamical systems in varied domains such as weather prediction, text prediction and several others. Often one wishes to supplement the experimentally observed dynamics with…

Disordered Systems and Neural Networks · Physics 2022-12-14 Sun-Ting Tsai , Eric Fields , Yijia Xu , En-Jui Kuo , Pratyush Tiwary

Implicit neural representations are a promising new avenue of representing general signals by learning a continuous function that, parameterized as a neural network, maps the domain of a signal to its codomain; the mapping from spatial…

Machine Learning · Computer Science 2021-11-09 Jaeho Lee , Jihoon Tack , Namhoon Lee , Jinwoo Shin

Neural networks have been achieving high generalization performance on many tasks despite being highly over-parameterized. Since classical statistical learning theory struggles to explain this behavior, much effort has recently been focused…

Machine Learning · Statistics 2021-06-16 Skander Karkar , Ibrahim Ayed , Emmanuel de Bézenac , Patrick Gallinari

Sampled structure sequences obtained, for instance, from real-time reactivity explorations or first-principles molecular dynamics simulations contain valuable information about chemical reactivity. Eventually, such sequences allow for the…

Chemical Physics · Physics 2018-04-25 Michael A. Heuer , Alain C. Vaucher , Moritz P. Haag , Markus Reiher

The Minima Hopping global optimization method uses physically realizable molecular dynamics moves in combination with an energy feedback that guarantees the escape from any potential energy funnel. For the purpose of finding reactions…

Materials Science · Physics 2014-06-05 Bastian Schaefer , Stephan Mohr , Maximilian Amsler , Stefan Goedecker

Pathways-reduced analysis is one of the techniques used by the Fispact-II nuclear activation and transmutation software to study the sensitivity of the computed inventories to uncertainties in reaction cross-sections. Although deciding…

Computational Physics · Physics 2016-05-19 Wayne Arter , J. Guy Morgan , Samuel D. Relton , Nicholas J. Higham

An analysis of the network defined by the potential energy minima of multi-atomic systems and their connectivity via reaction pathways that go through transition states allows to understand important characteristics like thermodynamic,…

Materials Science · Physics 2016-08-03 Bastian Schaefer , Stefan Goedecker

We propose a direct optimization framework for learning reduced and sparse chemical reaction networks (CRNs) from time-series trajectory data. In contrast to widely used indirect methods-such as those based on sparse identification of…

Molecular Networks · Quantitative Biology 2025-08-27 Maurice Filo , Mustafa Khammash

Sampling complex free energy surfaces is one of the main challenges of modern atomistic simulation methods. The presence of kinetic bottlenecks in such surfaces often renders a direct approach useless. A popular strategy is to identify a…

Computational Physics · Physics 2019-09-25 Luigi Bonati , Yue-Yu Zhang , Michele Parrinello

The development of chemical reaction models aids understanding and prediction in areas ranging from biology to electrochemistry and combustion. A systematic approach to building reaction network models uses observational data not only to…

Computational Engineering, Finance, and Science · Computer Science 2019-01-23 Nikhil Galagali , Youssef M. Marzouk