Related papers: On determination of the bifurcation type for a fre…
In this paper we deal with a free boundary problem modeling the growth of nonnecrotic tumors.The tumor is treated as an incompressible fluid, the tissue elasticity is neglected and no chemical inhibitor species are present. We re-express…
We introduce a 2D free boundary problem with nonlinear diffusion that models a living cell moving on a substrate. We prove that this nonlinearity results in a qualitative of solution behavior compared to the linear diffusion case (Rybalko…
A considerable number of research works has been devoted to the study of tumor models. Several biophysical factors, such as cell proliferation, apoptosis, chemotaxis, angiogenesis and necrosis, have been discovered to have an impact on the…
In this paper, a free boundary problem modelling the growth of tumor is considered. The model includes two reaction-diffusion equations modelling the diffusion of nutrient and drug in the tumor and three hyperbolic equations describing the…
We study the existence and multiplicity of solutions of the following free boundary problem $$ (P)\left\{ \begin{array}{rcll} \del u &=& \lam ( \eps +(1-\eps ) H(u-\mu))~ \hspace{3mm}&\text{in}~\Omega (t)\\ u&=&…
In this paper, a two-dimensional model for the growth of multi-layer tumors is presented. The model consists of a free boundary problem for the tumor cell membrane and the tumor is supposed to grow or shrink due to cell proliferation or…
In this paper, we consider a free boundary multi-layer tumor model that incorporates a $T-$periodic provision of external nutrients $\Phi(t)$. The simplified model contains three parameters: the mean of periodic external nutrients…
The present paper deals with a free boundary problem modeling the growth process of necrotic multi-layer tumors. We prove the existence of flat stationary solutions and determine the linearization of our model at such an equilibrium.…
In this paper we make rigorous mathematical analysis to a free boundary problem modeling the growth of necrotic tumors. A remarkable feature of this free boundary problem is that it contains two different-type free surfaces: One is the…
This paper is concerned with a multi-dimensional free boundary problem modeling the growth of a tumor with two species of cells: proliferating cells and quiescent cells. This free boundary problem has a unique radial stationary solution. By…
A two-dimensional free boundary model for the growth of multi-layer tumors has been proposed in [S. Cui, J. Escher: ARMA 191 (2009) 173-193] where the authors derive well-posedness in a functional analytic setting, the stationary solutions…
In this paper we study a linearized eigenvalue problem derived from a a free boundary problem modeling the growth of a tumor containing two species of cells: proliferating cells and quiescent cells. The reduced form of this eigenvalue…
In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…
At the continuous level, we consider two types of tumor growth models: the cell density model, which is based on the fluid mechanical construction, is more favorable for scientific interpretation and numerical simulations; and the free…
In this paper we study a nonlinear free boundary problem on the radial growth of a two-layer solid tumor with a quiescent core. The tumor surface and its inner interface separating the proliferating cells and the quiescent cells are both…
We are concerned with the global bifurcation analysis of positive solutions to free boundary problems arising in plasma physics. We show that in general, in the sense of domain variations, the following alternative holds: either the shape…
We use a bifurcation theory due to Crandall and Rabinowitz to show the existence of a symmetry breaking bifurcation of a specific one parameter family of axially symmetric disc type solutions of a membrane equation with fixed boundary. In…
This paper concerns multiphase models of tumor growth in interaction with a surrounding tissue, taking into account also the interplay with diffusible nutrients feeding the cells. Models specialize in nonlinear systems of possibly…
In this paper, we study a nonlinear free boundary problem modeling the growth of spherically symmetric tumors. The tumor consists of a central necrotic core, an intermediate annual quiescent-cell layer, and an outer proliferating-cell…
We develop an existence and regularity theory for solutions to a geometric free boundary problem motivated by models of tumor growth. In this setting, the tumor invades an accessible region $D$, its motion is directed along a constant…