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Estimating the eigenvalues of a population covariance matrix from a sample covariance matrix is a problem of fundamental importance in multivariate statistics; the eigenvalues of covariance matrices play a key role in many widely…

Statistics Theory · Mathematics 2007-06-13 Noureddine El Karoui

Functional magnetic resonance imaging (fMRI) aims to locate activated regions in human brains when specific tasks are performed. The conventional tool for analyzing fMRI data applies some variant of the linear model, which is restrictive in…

Statistics Theory · Mathematics 2008-08-08 Chunming Zhang , Tao Yu

In this paper we study the problem of reconstruction of a low-rank matrix observed with additive Gaussian noise. First we show that under mild assumptions (about the prior distribution of the signal matrix) we can restrict our attention to…

Methodology · Statistics 2010-07-26 Andrey Shabalin , Andrew Nobel

Progress in natural language processing (NLP) models that estimate representations of word sequences has recently been leveraged to improve the understanding of language processing in the brain. However, these models have not been…

Neurons and Cognition · Quantitative Biology 2019-11-11 Dan Schwartz , Mariya Toneva , Leila Wehbe

Large efforts are currently under way to systematically map functional connectivity between all pairs of millimeter-scale brain regions using big volumes of neuroimaging data. Functional magnetic resonance imaging (fMRI) can produce these…

Neurons and Cognition · Quantitative Biology 2014-09-24 Enzo Tagliazucchi , Helmut Laufs , Dante R. Chialvo

Modern Machine Learning (ML) and Deep Neural Networks (DNNs) often operate on high-dimensional data and rely on overparameterized models, where classical low-dimensional intuitions break down. In particular, the proportional regime where…

Machine Learning · Statistics 2026-04-17 Zhenyu Liao , Michael W. Mahoney

Dimensional reduction of high dimensional data can be achieved by keeping only the relevant eigenmodes after principal component analysis. However, differentiating relevant eigenmodes from the random noise eigenmodes is problematic. A new…

Data Analysis, Statistics and Probability · Physics 2008-12-31 Yu Ding , Yiu-Cho Chung , Kun Huang , Orlando P. Simonetti

Using random matrix technique we determine an exact relation between the eigenvalue spectrum of the covariance matrix and of its estimator. This relation can be used in practice to compute eigenvalue invariants of the covariance…

Statistical Mechanics · Physics 2010-01-15 Z. Burda , A. Goerlich , A. Jarosz , J. Jurkiewicz

Functional connectivity (FC) analysis of resting-state fMRI data provides a framework for characterizing brain networks and their association with participant-level covariates. Due to the high dimensionality of neuroimaging data, standard…

Methodology · Statistics 2025-08-18 Wei Zhao , Brian J. Reich , Emily C. Hector

Machine learning (ML) is rapidly transforming the way molecular dynamics simulations are performed and analyzed, from materials modeling to studies of protein folding and function. ML algorithms are often employed to learn low-dimensional…

Soft Condensed Matter · Physics 2025-09-23 Jayashrita Debnath , Gerhard Hummer

Brain connectivity analysis is now at the foreground of neuroscience research. A connectivity network is characterized by a graph, where nodes represent neural elements such as neurons and brain regions, and links represent statistical…

Methodology · Statistics 2015-11-04 Yin Xia , Lexin Li

Large language models and deep neural networks achieve strong performance but suffer from reliability issues and high computational cost. This thesis proposes a unified framework based on spectral geometry and random matrix theory to…

Machine Learning · Computer Science 2026-01-27 Davide Ettori

Reconstructing digital brain phantoms in the form of voxel-based, multi-channeled tissue probability maps for individual subjects is essential for capturing brain anatomical variability, understanding neurological diseases, as well as for…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Utkarsh Gupta , Emmanouil Nikolakakis , Moritz Zaiss , Razvan Marinescu

Machine learning (ML) has revolutionized medical prognostics by integrating advanced algorithms with clinical data to enhance disease prediction, risk assessment, and patient outcome forecasting. This comprehensive review critically…

Machine Learning · Computer Science 2024-08-06 Michael Fascia

Accurate measurement of spatially variant noise in dynamic magnetic resonance (MR) images acquired using parallel imaging methods is problematic. We propose a new method based on the random matrix theory to accurately assess the noise…

Data Analysis, Statistics and Probability · Physics 2009-06-10 Yu Ding , Yiu-Cho Chung , Orlando P. Simonetti

Random matrix theory (RMT) provides a common mathematical formulation of distinct physical questions in three different areas: quantum chaos, the 1-d integrable model with the $1/r^2$ interaction (the Calogero-Sutherland-Moser system), and…

High Energy Physics - Theory · Physics 2009-10-30 Sanjay Jain

To measure the volume of specific image structures, a typical approach is to first segment those structures using a neural network trained on voxel-wise (strong) labels and subsequently compute the volume from the segmentation. A more…

Image and Video Processing · Electrical Eng. & Systems 2020-04-14 Oliver Werner , Kimberlin M. H. van Wijnen , Wiro J. Niessen , Marius de Groot , Meike W. Vernooij , Florian Dubost , Marleen de Bruijne

There has been increasing interests in learning resting-state brain functional connectivity of autism disorders using functional magnetic resonance imaging (fMRI) data. The data in a standard brain template consist of over 200,000 voxel…

Methodology · Statistics 2016-03-22 Jichun Xie , Jian Kang

Brain-mapping techniques have proven to be vital in understanding the molecular, cellular, and functional mechanisms of the brain. Normal anatomical imaging can provide structural information on certain abnormalities in the brain. However…

Emerging Technologies · Computer Science 2013-01-03 Nivedita Daimiwal , M. Sundhararajan , Revati Shriram

The field of neuroimaging has truly become data rich, and novel analytical methods capable of gleaning meaningful information from large stores of imaging data are in high demand. Those methods that might also be applicable on the level of…