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Large Language Models (LLMs) are transforming scientific hypothesis generation and validation by enabling information synthesis, latent relationship discovery, and reasoning augmentation. This survey provides a structured overview of…

Language models (LMs), including large language models (such as ChatGPT), have the potential to assist clinicians in generating various clinical notes. However, LMs are prone to produce ``hallucinations'', i.e., generated content that is…

Computation and Language · Computer Science 2024-07-23 Fenglin Liu , Bang Yang , Chenyu You , Xian Wu , Shen Ge , Zhangdaihong Liu , Xu Sun , Yang Yang , David A. Clifton

Large-scale language models (LLMs) have emerged as a groundbreaking innovation in the realm of question-answering and conversational agents. These models, leveraging different deep learning architectures such as Transformers, are trained on…

Software Engineering · Computer Science 2023-07-18 Fardin Ahsan Sakib , Saadat Hasan Khan , A. H. M. Rezaul Karim

Patient matching is the process of linking patients to appropriate clinical trials by accurately identifying and matching their medical records with trial eligibility criteria. We propose LLM-Match, a novel framework for patient matching…

Computation and Language · Computer Science 2025-03-26 Xiaodi Li , Shaika Chowdhury , Chung Il Wi , Maria Vassilaki , Xiaoke Liu , Terence T Sio , Owen Garrick , Young J Juhn , James R Cerhan , Cui Tao , Nansu Zong

Biomedical knowledge graphs (KGs) are vital for drug discovery and clinical decision support but remain incomplete. Large language models (LLMs) excel at extracting biomedical relations, yet their outputs lack standardization and alignment…

Information Retrieval · Computer Science 2025-12-01 Olawumi Olasunkanmi , Mathew Satusky , Hong Yi , Chris Bizon , Harlin Lee , Stanley Ahalt

The primary aim of this research was to address the limitations observed in the medical knowledge of prevalent large language models (LLMs) such as ChatGPT, by creating a specialized language model with enhanced accuracy in medical advice.…

Computation and Language · Computer Science 2023-06-27 Yunxiang Li , Zihan Li , Kai Zhang , Ruilong Dan , Steve Jiang , You Zhang

Existing LLM-based medical question-answering systems lack citation generation and evaluation capabilities, raising concerns about their adoption in practice. In this work, we introduce \name, the first end-to-end framework that facilitates…

Computation and Language · Computer Science 2025-06-10 Xiao Wang , Mengjue Tan , Qiao Jin , Guangzhi Xiong , Yu Hu , Aidong Zhang , Zhiyong Lu , Minjia Zhang

An important issue impacting healthcare is a lack of available experts. Machine learning (ML) models could resolve this by aiding in diagnosing patients. However, creating datasets large enough to train these models is expensive. We…

Computation and Language · Computer Science 2024-05-14 Chancellor R. Woolsey , Prakash Bisht , Joshua Rothman , Gondy Leroy

ChatGPT, as a recently launched large language model (LLM), has shown superior performance in various natural language processing (NLP) tasks. However, two major limitations hinder its potential applications: (1) the inflexibility of…

Computation and Language · Computer Science 2023-09-20 Yucheng Shi , Hehuan Ma , Wenliang Zhong , Qiaoyu Tan , Gengchen Mai , Xiang Li , Tianming Liu , Junzhou Huang

The intricate relationship between genetic variation and human diseases has been a focal point of medical research, evidenced by the identification of risk genes regarding specific diseases. The advent of advanced genome sequencing…

Quantitative Methods · Quantitative Biology 2024-01-19 Jiayu Chang , Shiyu Wang , Chen Ling , Zhaohui Qin , Liang Zhao

This study applies Large Language Models (LLMs) to two foundational Electronic Health Record (EHR) data science tasks: structured data querying (using programmatic languages, Python/Pandas) and information extraction from unstructured…

Computation and Language · Computer Science 2026-01-29 Juan Jose Rubio Jan , Jack Wu , Julia Ive

Evidence to guide healthcare decisions is often limited by a lack of relevant and trustworthy literature as well as difficulty in contextualizing existing research for a specific patient. Large language models (LLMs) could potentially…

The use of ChatGPT and similar Large Language Model (LLM) tools in scholarly communication and academic publishing has been widely discussed since they became easily accessible to a general audience in late 2022. This study uses keywords…

Digital Libraries · Computer Science 2024-03-26 Andrew Gray

The use of large language models (LLMs) in scholarly publications has grown dramatically since the launch of ChatGPT in late 2022. This usage is often undisclosed, and it can be challenging for readers and reviewers to identify human…

Digital Libraries · Computer Science 2025-12-02 Andrew Gray

Large Language Models (LLMs) are being adopted at an unprecedented rate, yet still face challenges in knowledge-intensive domains like biomedicine. Solutions such as pre-training and domain-specific fine-tuning add substantial computational…

Clinical natural language processing requires methods that can address domain-specific challenges, such as complex medical terminology and clinical contexts. Recently, large language models (LLMs) have shown promise in this domain. Yet,…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hejie Cui , Yue Yu , Xuan Kan , Wenqi Shi , Yuchen Zhuang , Wei Jin , Joyce Ho , Carl Yang

Large Language Models (LLMs) are increasingly adopted for applications in healthcare, reaching the performance of domain experts on tasks such as question answering and document summarisation. Despite their success on these tasks, it is…

Computation and Language · Computer Science 2025-05-20 Aishik Nagar , Viktor Schlegel , Thanh-Tung Nguyen , Hao Li , Yuping Wu , Kuluhan Binici , Stefan Winkler

Large language models (LLMs), such as ChatGPT, are able to generate human-like, fluent responses for many downstream tasks, e.g., task-oriented dialog and question answering. However, applying LLMs to real-world, mission-critical…

Computation and Language · Computer Science 2023-03-10 Baolin Peng , Michel Galley , Pengcheng He , Hao Cheng , Yujia Xie , Yu Hu , Qiuyuan Huang , Lars Liden , Zhou Yu , Weizhu Chen , Jianfeng Gao

Large Language Models (LLMs) have shown remarkable capabilities in general domains but often struggle with tasks requiring specialized knowledge. Conventional Retrieval-Augmented Generation (RAG) techniques typically retrieve external…

Computation and Language · Computer Science 2025-02-20 Yucheng Shi , Tianze Yang , Canyu Chen , Quanzheng Li , Tianming Liu , Xiang Li , Ninghao Liu

Scientific metadata are often incomplete and noncompliant with community standards, limiting dataset findability, interoperability, and reuse. When reporting guidelines exist, they typically lack machine-actionable representations.…

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