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We propose a novel method to describe realistically ionization processes with absorbing boundary conditions in basis expansion within the formalism of the so-called Non-Adiabatic Quantum Molecular Dynamics. This theory couples…

Quantum Physics · Physics 2015-06-26 Mathias Uhlmann , Thomas Kunert , Ruediger Schmidt

Molecular dynamics simulations are an important tool for describing the evolution of a chemical system with time. However, these simulations are inherently held back either by the prohibitive cost of accurate electronic structure theory…

Chemical Physics · Physics 2018-12-20 Michael Gastegger , Philipp Marquetand

The molecular simulations solve the equation of motion of molecular systems, making 3D shapes of molecules four-dimensional by adding the time coordinate. These methods have a great potential in drug discovery because they can realistically…

Biomolecules · Quantitative Biology 2023-01-19 Dalibor Trapl , Vojtěch Spiwok

Molecular dynamics simulations have the potential to provide atomic-level detail and insight to important questions in chemical physics that cannot be observed in typical experiments. However, simply generating a long trajectory is…

Chemical Physics · Physics 2015-06-22 Christian R. Schwantes , Robert T. McGibbon , Vijay S. Pande

Quantum algorithms are prominent in the pursuit of achieving quantum advantage in various computational tasks. However, addressing challenges, such as limited qubit coherence and high error rate in near-term devices, requires extensive…

Quantum Physics · Physics 2024-07-31 Julián Ferreiro-Vélez , Iñaki Iriarte-Zendoia , Yue Ban , Xi Chen

Nonadiabatic couplings (NACs) play a crucial role in modeling photochemical and photophysical processes with methods such as the widely used fewest-switches surface hopping (FSSH). There is therefore a strong incentive to machine learn NACs…

Computational Physics · Physics 2026-03-17 Jakub Martinka , Lina Zhang , Yi-Fan Hou , Mikołaj Martyka , Jiří Pittner , Mario Barbatti , Pavlo O. Dral

Molecular dynamics with electronic friction (MDEF) approach can describe nonadiabatic effects accurately at metal surfaces in the weak nonadiabatic limit. That being said, MDEF treats nuclear motion classically, such that the nuclear…

Chemical Physics · Physics 2024-04-09 Rui-Hao Bi , Wenjie Dou

Ordinary differential equation models are nowadays widely used for the mechanistic description of biological processes and their temporal evolution. These models typically have many unknown and non-measurable parameters, which have to be…

Quantitative Methods · Quantitative Biology 2021-05-27 Alejandro F. Villaverde , Dilan Pathirana , Fabian Fröhlich , Jan Hasenauer , Julio R. Banga

Neuromorphic computing shows promise for advancing computing efficiency and capabilities of AI applications using brain-inspired principles. However, the neuromorphic research field currently lacks standardized benchmarks, making it…

Artificial Intelligence · Computer Science 2025-01-16 Jason Yik , Korneel Van den Berghe , Douwe den Blanken , Younes Bouhadjar , Maxime Fabre , Paul Hueber , Weijie Ke , Mina A Khoei , Denis Kleyko , Noah Pacik-Nelson , Alessandro Pierro , Philipp Stratmann , Pao-Sheng Vincent Sun , Guangzhi Tang , Shenqi Wang , Biyan Zhou , Soikat Hasan Ahmed , George Vathakkattil Joseph , Benedetto Leto , Aurora Micheli , Anurag Kumar Mishra , Gregor Lenz , Tao Sun , Zergham Ahmed , Mahmoud Akl , Brian Anderson , Andreas G. Andreou , Chiara Bartolozzi , Arindam Basu , Petrut Bogdan , Sander Bohte , Sonia Buckley , Gert Cauwenberghs , Elisabetta Chicca , Federico Corradi , Guido de Croon , Andreea Danielescu , Anurag Daram , Mike Davies , Yigit Demirag , Jason Eshraghian , Tobias Fischer , Jeremy Forest , Vittorio Fra , Steve Furber , P. Michael Furlong , William Gilpin , Aditya Gilra , Hector A. Gonzalez , Giacomo Indiveri , Siddharth Joshi , Vedant Karia , Lyes Khacef , James C. Knight , Laura Kriener , Rajkumar Kubendran , Dhireesha Kudithipudi , Shih-Chii Liu , Yao-Hong Liu , Haoyuan Ma , Rajit Manohar , Josep Maria Margarit-Taulé , Christian Mayr , Konstantinos Michmizos , Dylan R. Muir , Emre Neftci , Thomas Nowotny , Fabrizio Ottati , Ayca Ozcelikkale , Priyadarshini Panda , Jongkil Park , Melika Payvand , Christian Pehle , Mihai A. Petrovici , Christoph Posch , Alpha Renner , Yulia Sandamirskaya , Clemens JS Schaefer , André van Schaik , Johannes Schemmel , Samuel Schmidgall , Catherine Schuman , Jae-sun Seo , Sadique Sheik , Sumit Bam Shrestha , Manolis Sifalakis , Amos Sironi , Kenneth Stewart , Matthew Stewart , Terrence C. Stewart , Jonathan Timcheck , Nergis Tömen , Gianvito Urgese , Marian Verhelst , Craig M. Vineyard , Bernhard Vogginger , Amirreza Yousefzadeh , Fatima Tuz Zohora , Charlotte Frenkel , Vijay Janapa Reddi

Molecular docking plays a crucial role in predicting the binding mode of ligands to target proteins, and covalent interactions, which involve the formation of a covalent bond between the ligand and the target, are particularly valuable due…

Biomolecules · Quantitative Biology 2025-06-27 Yangzhe Peng , Kaiyuan Gao , Liang He , Yuheng Cong , Haiguang Liu , Kun He , Lijun Wu

Accurate and efficient methods to simulate nonadiabatic and quantum nuclear effects in high-dimensional and dissipative systems are crucial for the prediction of chemical dynamics in condensed phase. To facilitate effective development,…

Most computer simulations of molecular dynamics take place under equilibrium conditions--in a closed, isolated system, or perhaps one held at constant temperature or pressure. Sometimes, extra tensions, shears, or temperature gradients are…

Statistical Mechanics · Physics 2022-05-25 Alex Albaugh , Todd R. Gingrich

GROMACS is a widely used package for biomolecular simulation, and over the last two decades it has evolved from small-scale efficiency to advanced heterogeneous acceleration and multi-level parallelism targeting some of the largest…

Computational Engineering, Finance, and Science · Computer Science 2015-06-03 Páll Szilárd , Mark James Abraham , Carsten Kutzner , Berk Hess , Erik Lindahl

An approach to non-adiabatic dynamics of atoms in molecular and condensed matter systems under general non-equilibrium conditions is proposed. In this method interaction between nuclei and electrons is considered explicitly up to the second…

Materials Science · Physics 2018-08-01 L. Kantorovich

Inelastic collisions and elementary chemical reactions proceeding through the formation and subsequent decay of an intermediate collision complex, with an associated deep well on the potential energy surface, pose a challenge for accurate…

Chemical Physics · Physics 2022-06-10 Maarten Konings , Benjamin Desrousseaux , François Lique , Jérôme Loreau

Molecular dynamics with the stochastic process provides a convenient way to compute structural and thermodynamic properties of chemical, biological, and materials systems. It is demonstrated that the virtual dynamics case that we proposed…

Statistical Mechanics · Physics 2018-03-20 Dezhang Li , Zifei Chen , Zhijun Zhang , Jian Liu

Molecular machine learning has been maturing rapidly over the last few years. Improved methods and the presence of larger datasets have enabled machine learning algorithms to make increasingly accurate predictions about molecular…

We develop a unified quantum geometric framework to understand reactive quantum dynamics. The critical roles of the quantum geometry of adiabatic electronic states in both adiabatic and non-adiabatic quantum dynamics are unveiled. A…

Chemical Physics · Physics 2025-05-19 Yujuan Xie , Ruoxi Liu , Bing Gu

Development and operation of commercially viable fusion energy reactors such as tokamaks require accurate predictions of plasma dynamics from sparse, noisy, and incomplete sensors readings. The complexity of the underlying physics and the…

An accurate description of nonadiabatic dynamics of molecular species on metallic surfaces poses a serious computational challenge associated with a multitude of closely-spaced electronic states. We propose a mixed quantum-classical scheme…

Chemical Physics · Physics 2017-01-10 Ilya G. Ryabinkin , Artur F. Izmaylov