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The formation of coacervates through phase separation of oppositely charged polyelectrolytes (PEs) is critical for understanding biological condensates and developing responsive materials. Traditionally, coacervates are viewed as spherical…

Soft Condensed Matter · Physics 2024-12-23 Jiaxing Yuan , Hajime Tanaka

Liquid-liquid phase separation has emerged as one of the important paradigms in the chemical physics as well as biophysics of charged macromolecular systems. We elucidate an equilibrium phase separation mechanism based on charge regulation,…

Soft Condensed Matter · Physics 2020-12-25 Arghya Majee , Markus Bier , Ralf Blossey , Rudolf Podgornik

Understanding the behavior of charged complex fluids is crucial for a plethora of important industrial, technological, and medical applications. Using coarse-grained molecular dynamics simulations, here we investigate the properties of a…

Soft Condensed Matter · Physics 2022-08-04 Debarshee Bagchi

We introduce a generalized non-uniform mean-field formalism to describe the dissociation of weak rod-like polyelectrolytes (PEs). Our approach allows for two-sublattice symmetry breaking which in titration curves is associated with a…

Soft Condensed Matter · Physics 2007-05-23 Y. Burak , R. R. Netz

Electrostatic interactions in polymeric systems are responsible for a wide range of liquid-liquid phase transitions that are of importance for biology and materials science. Such transitions are referred to as complex coacervation, and…

Soft Condensed Matter · Physics 2023-09-29 Boyuan Yu , Heyi Liang , Paul F. Nealey , Matthew Tirrell , Artem M. Rumyantsev , Juan J. de Pablo

Complex coacervation, known as the liquid-liquid phase separation of solutions with oppositely charged polyelectrolytes, has attracted substantial interest in recent years. We study the effect of the charge regulation (CR) mechanism on the…

Soft Condensed Matter · Physics 2021-07-23 Bin Zheng , Yael Avni , David Andelman , Rudolf Podgornik

Coupled ionic and electronic transport underpins processes as diverse as electrochemical energy conversion, biological signaling, and soft adaptive electronics. Yet, how chemical environments such as pH modulate this coupling at the…

It is generally assumed that hydrodynamics in dense polyelectrolyte (PE) solutions, such as semidilute PE solutions and PE complex coacervates, is heavily screened and inconsequential. Here, using mesoscale molecular dynamics that…

Soft Condensed Matter · Physics 2024-09-17 Shensheng Chen , Zhen-Gang Wang

The influence of the chain degree of ionization on the adsorption of weak polyelectrolytes on neutral and on oppositely and likely charged surfaces is investigated for the first time, by means of Monte Carlo simulations with the mesoscopic…

Biological Physics · Physics 2012-10-02 F. Alarcón , E. Pérez , A. Gama Goicochea

In this work, a comprehensive study about the influence on shear viscosity of polyelectrolyte concentration, persistence length, salt concentration and solvent quality is reported, using numerical simulations of confined solutions under…

Soft Condensed Matter · Physics 2022-11-22 Estela Mayoral , Juan de Dios Hernández Velázquez , Armando Gama Goicochea

We investigate theoretically the phase diagram of an insoluble charged surfactant monolayer in contact with a semi-dilute polyelectrolyte solution (of opposite charge). The polyelectrolytes are assumed to have long-range and attractive…

Soft Condensed Matter · Physics 2012-07-19 Adi Shafir , David Andelman

Globular proteins as well as recently synthesized colloids engineered with differently charged surface regions have in common a reduced bonding valence and a complex interaction pattern dominated by like-charge attraction and…

Soft Condensed Matter · Physics 2024-02-02 Daniele Notarmuzi , Emanuela Bianchi

The functionalities and applications of complex coacervates -- liquid condensates resulting from liquid-liquid phase separation of charged polymers -- are significantly influenced by the dispersion and aggregation states of guest…

Soft Condensed Matter · Physics 2025-08-05 Zongpei Wu , Shensheng Chen

We study phase equilibria in a minimal model of charge-regulated polymer solutions. Our model consists of a single polymer species whose charge state arises from protonation-deprotonation processes in the presence of a dissolved acid, whose…

Soft Condensed Matter · Physics 2023-11-14 Giulia L. Celora , Ralf Blossey , Andreas Münch , Barbara Wagner

We present a theory for phase-separated liquid coacervates with salt, taking into account spatial heterogeneities and interfacial profiles. We find that charged layers of alternating sign can form around the interface while the bulk phases…

Soft Condensed Matter · Physics 2024-08-07 Arghya Majee , Christoph A. Weber , Frank Jülicher

Within the Poisson-Boltzmann (PB) approach electrolytes in contact with planar, spherical, and cylindrical electrodes are analyzed systematically. The dependences of their capacitance $C$ on the surface charge density $\sigma$ and the ionic…

Soft Condensed Matter · Physics 2017-04-24 Andreas Reindl , Markus Bier , S. Dietrich

A new type of phase separation in the polyelectrolyte solutions consisting of several types of charged macromolecules differing in their degree of ionization is predicted via a general thermodynamic consideration. We show that even a small…

Soft Condensed Matter · Physics 2011-11-09 Igor Erukhimovich , Monica Olvera de la Cruz

Phase separation in salt-free symmetric mixtures of oppositely charged rodlike polyelectrolytes is studied using quasi-analytical calculations. Stability analyses for the isotropic-isotropic and the isotropic-nematic phase transitions in…

Soft Condensed Matter · Physics 2010-07-20 Rajeev Kumar , Debra Audus , Glenn H. Fredrickson

Using the complex Langevin sampling strategy, field theoretic simulations are performed to study the equilibrium phase behavior and structure of symmetric polycation-polyanion mixtures without salt in good solvents. Static structure factors…

Soft Condensed Matter · Physics 2008-06-14 Jonghoon Lee , Yuri O. Popov , Glenn H. Fredrickson

We present a minimal model to study liquid phase separation in a fixed pH ensemble. The model describes a mixture composed of macromolecules that exist in three different charge states and have a tendency to phase separate. We introduce the…

Biological Physics · Physics 2020-10-30 Omar Adame-Arana , Christoph A. Weber , Vasily Zaburdaev , Jacques Prost , Frank Jülicher
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