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Explainability is a critical factor in enhancing the trustworthiness and acceptance of artificial intelligence (AI) in healthcare, where decisions directly impact patient outcomes. Despite advancements in AI interpretability, clear…

Artificial Intelligence · Computer Science 2025-05-15 Michail Mamalakis , Héloïse de Vareilles , Graham Murray , Pietro Lio , John Suckling

Medical AI algorithms can often experience degraded performance when evaluated on previously unseen sites. Addressing cross-site performance disparities is key to ensuring that AI is equitable and effective when deployed on diverse patient…

Machine Learning · Computer Science 2021-11-17 Eric Wu , Kevin Wu , James Zou

The inherent "black box" nature of deep neural networks (DNNs) compromises their transparency and reliability. Recently, explainable AI (XAI) has garnered increasing attention from researchers. Several perturbation-based interpretations…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Xuran Hu , Mingzhe Zhu , Zhenpeng Feng , Miloš Daković , Ljubiša Stanković

The simulation of complex systems increasingly relies on sophisticated but fundamentally opaque computational black-box simulators. Surrogate models play a central role in reducing the computational cost of complex systems simulations…

Artificial intelligence (AI) models trained using medical images for clinical tasks often exhibit bias in the form of disparities in performance between subgroups. Since not all sources of biases in real-world medical imaging data are…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Emma A. M. Stanley , Raissa Souza , Anthony Winder , Vedant Gulve , Kimberly Amador , Matthias Wilms , Nils D. Forkert

In the last years many accurate decision support systems have been constructed as black boxes, that is as systems that hide their internal logic to the user. This lack of explanation constitutes both a practical and an ethical issue. The…

Computers and Society · Computer Science 2018-06-22 Riccardo Guidotti , Anna Monreale , Salvatore Ruggieri , Franco Turini , Dino Pedreschi , Fosca Giannotti

The evolution of deep learning and artificial intelligence has significantly reshaped technological landscapes. However, their effective application in crucial sectors such as medicine demands more than just superior performance, but…

Computer Vision and Pattern Recognition · Computer Science 2024-02-27 Yasmine Mustafa , Tie Luo

The use of AI systems in healthcare for the early screening of diseases is of great clinical importance. Deep learning has shown great promise in medical imaging, but the reliability and trustworthiness of AI systems limit their deployment…

Image and Video Processing · Electrical Eng. & Systems 2023-05-17 Ke Zou , Zhihao Chen , Xuedong Yuan , Xiaojing Shen , Meng Wang , Huazhu Fu

The use of artificial intelligence (AI) in healthcare has become a very active research area in the last few years. While significant progress has been made in image classification tasks, only a few AI methods are actually being deployed in…

Image and Video Processing · Electrical Eng. & Systems 2021-11-18 Ramon Correa , Jiwoong Jason Jeong , Bhavik Patel , Hari Trivedi , Judy W. Gichoya , Imon Banerjee

With the increasingly widespread adoption of AI in healthcare, maintaining the accuracy and reliability of AI models in clinical practice has become crucial. In this context, we introduce novel methods for monitoring the performance of…

Artificial Intelligence · Computer Science 2023-11-27 Vasantha Kumar Venugopal , Abhishek Gupta , Rohit Takhar , Vidur Mahajan

Explainability features are intended to provide insight into the internal mechanisms of an AI device, but there is a lack of evaluation techniques for assessing the quality of provided explanations. We propose a framework to assess and…

Artificial Intelligence · Computer Science 2025-06-18 Miguel A. Lago , Ghada Zamzmi , Brandon Eich , Jana G. Delfino

Last years have been characterized by an upsurge of opaque automatic decision support systems, such as Deep Neural Networks (DNNs). Although they have great generalization and prediction skills, their functioning does not allow obtaining…

Chemical disorder, originating from the mixed occupation of crystallographic sites by multiple elements, is widespread in alloys, ceramics, and compositionally complex materials, where short- and long-range orderings can strongly influence…

Materials Science · Physics 2026-05-20 Jiayu Peng , Peichen Zhong

Estimating the test performance of software AI-based medical devices under distribution shifts is crucial for evaluating the safety, efficiency, and usability prior to clinical deployment. Due to the nature of regulated medical device…

Machine Learning · Computer Science 2022-07-14 Charles Lu , Syed Rakin Ahmed , Praveer Singh , Jayashree Kalpathy-Cramer

Explainability techniques for data-driven predictive models based on artificial intelligence and machine learning algorithms allow us to better understand the operation of such systems and help to hold them accountable. New transparency…

Machine Learning · Computer Science 2022-09-09 Kacper Sokol , Alexander Hepburn , Raul Santos-Rodriguez , Peter Flach

With the increasing availability of structured and unstructured data and the swift progress of analytical techniques, Artificial Intelligence (AI) is bringing a revolution to the healthcare industry. With the increasingly indispensable role…

Machine Learning · Computer Science 2020-11-09 Devam Dave , Het Naik , Smiti Singhal , Pankesh Patel

Modern AI systems frequently rely on opaque black-box models, most notably Deep Neural Networks, whose performance stems from complex architectures with millions of learned parameters. While powerful, their complexity poses a major…

Machine Learning · Computer Science 2026-02-23 David Dembinsky , Adriano Lucieri , Stanislav Frolov , Hiba Najjar , Ko Watanabe , Andreas Dengel

Many decision making systems deployed in the real world are not static - a phenomenon known as model adaptation takes place over time. The need for transparency and interpretability of AI-based decision models is widely accepted and thus…

Machine Learning · Computer Science 2021-04-08 André Artelt , Fabian Hinder , Valerie Vaquet , Robert Feldhans , Barbara Hammer

Artificial intelligence (AI) systems increasingly match or surpass human experts in biomedical signal interpretation. However, their effective integration into clinical practice requires more than high predictive accuracy. Clinicians must…

Machine Learning · Computer Science 2025-10-27 Stefan Kraft , Andreas Theissler , Vera Wienhausen-Wilke , Gjergji Kasneci , Hendrik Lensch

Machine learning (ML) models, demonstrably powerful, suffer from a lack of interpretability. The absence of transparency, often referred to as the black box nature of ML models, undermines trust and urges the need for efforts to enhance…

Machine Learning · Computer Science 2024-06-25 Fatima Ezzeddine
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