Related papers: Application of autoresonance in rapid beam extract…
FLASH radiation therapy calls for the delivery of fast bursted spills of particles with dose delivery times of the order of milliseconds. The requirements overlap with fundamental physics experimental requests that are being studied at…
This paper proposes a novel method for resonant slow extraction in synchrotrons by using special anti-symmetric sextupole fields, which can be produced by a special magnet structure. The method has the potential in applications demanding…
Radio Frequency Knock Out resonant slow extraction is a standard method for extracting stored particle beams from synchrotrons by transverse excitation. Classically, the beam is excited with an RF field comprising a frequency band around…
One challenge on the path to delivering FLASH-compatible beams with a synchrotron is facilitating an accurate dose-control for the required ultra-high dose rates. We propose the use of pulsed RFKO extraction instead of continuous beam…
Radio frequency knock out resonant slow extraction is a standard method for extracting stored particle beams from synchrotrons by transverse excitation. Excitation signals comprising many betatron sidebands have shown to reduce intensity…
Autoresonant phase-locking of the plasma wakefield to the beat frequency of two driving lasers offers advantages over conventional wakefield acceleration methods, since it requires less demanding laser parameters and is robust to variations…
Conventional cancer therapies include surgery, radiation therapy, chemotherapy, and, more recently, immunotherapy. These modalities are often combined to improve the therapeutic index. The general concept of radiation therapy is to increase…
Slow resonant extraction from synchrotrons via radio-frequency knock-out is a well-established technique to deliver charged particle beams for various applications. In this contribution, we present explicit analytical expressions for…
For resonant slow extraction of accelerated particle beams from synchrotrons, a 3rd order resonance driven by sextupole magnets is commonly used. This note reviews the non-linear particle dynamics under these conditions as described by the…
This paper presents the design of a rapid cycling synchrotron (RCS) featuring a longitudinal localized kick driven fast extraction system for three-dimensional (3D) pencil beam scanning (PBS) proton FLASH delivery. The extraction method is…
The Circular Electron-Positron Collider (CEPC) can also work as a powerful and excellent synchrotron light source, which can generate high-quality synchrotron radiation. This synchrotron radiation has potential advantages in the medical…
Radiotherapy with Very High Energy Electron (VHEE) beams is being extensively investigated for the treatment of deep-seated tumours, even in view of novel protocols based on the so-called FLASH effect. Laser WakeField Acceleration (LWFA)…
We present a compact, cost-effective method for measuring the emittance of kHz-repetition-rate laser-wakefield accelerated electron beams using a permanent solenoid. The measured normalized emittance, $\epsilon_n = 124\,\mathrm{nm \cdot…
While spatial dose conformity delivered to a target volume has been pushed to its practical limits with advanced treatment planning and delivery, investigations in novel temporal dose delivery are unfolding new mechanisms. Recent advances…
Laser-driven proton sources have long been developed with an eye on their potential for medical application to radiation therapy. These sources are compact, versatile, and show peculiar characteristics such as extreme instantaneous dose…
Manual annotation of pathology slides for cancer diagnosis is laborious and repetitive. Therefore, much effort has been devoted to develop computer vision solutions. Our approach, (FLASH), is based on a Deep Convolutional Neural Network…
We introduce a fast Eikonal Phase Retrieval (EPR) formulation that accelerates eikonal phase retrieval by more than two orders of magnitude while retaining controlled accuracy. The method is derived from a second-order asymptotic expansion…
FLASH radiotherapy (FLASH-RT) achieves tumor control comparable to conventional dose-rate irradiation (CONV-RT) while significantly reducing radiation damage to normal tissues. However, the physical conditions triggering the FLASH sparing…
Ultra-high intensity laser-plasma interactions can produce ultra-relativistic electrons via direct laser acceleration, assisted by quasi-static plasma magnetic and electric fields. These fields transversely confine electron motion and…
It has been postulated that the delivery of radiotherapy at ultra-high dose rates ("FLASH") reduces normal tissue toxicities by depleting them of oxygen. The fraction of normal tissue and cancer cells surviving radiotherapy depends on dose…