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Background: Clinical trials rely on transparent inclusion criteria to ensure generalizability. In contrast, benchmarks validating health-related large language models (LLMs) rarely characterize the "patient" or "query" populations they…

Artificial Intelligence · Computer Science 2026-04-17 Alvin Rajkomar , Pavan Sudarshan , Angela Lai , Lily Peng

Irregular sampling and high missingness are intrinsic challenges in modeling time series derived from electronic health records (EHRs),where clinical variables are measured at uneven intervals depending on workflow and intervention timing.…

Machine Learning · Computer Science 2025-09-29 Jeong Eul Kwon , Joo Heung Yoon , Hyo Kyung Lee

Evaluating large language models (LLMs) in medicine is crucial because medical applications require high accuracy with little room for error. Current medical benchmarks have three main types: medical exam-based, comprehensive medical, and…

With increased power and prevalence of AI systems, it is ever more critical that AI systems are designed to serve all, i.e., people with diverse values and perspectives. However, aligning models to serve pluralistic human values remains an…

As large language models are increasingly deployed in sensitive domains such as healthcare, ensuring their outputs reflect the diverse values and perspectives held across populations is critical. However, existing alignment approaches,…

Computation and Language · Computer Science 2025-09-19 Jiayou Zhong , Anudeex Shetty , Chao Jia , Xuanrui Lin , Usman Naseem

How can large language models (LLMs) serve users with varying preferences that may conflict across cultural, political, or other dimensions? To advance this challenge, this paper establishes four key results. First, we demonstrate, through…

As Large Language Models (LLMs) achieve remarkable breakthroughs, aligning their values with humans has become imperative for their responsible development and customized applications. However, there still lack evaluations of LLMs values…

Artificial Intelligence · Computer Science 2025-06-03 Jing Yao , Xiaoyuan Yi , Shitong Duan , Jindong Wang , Yuzhuo Bai , Muhua Huang , Peng Zhang , Tun Lu , Zhicheng Dou , Maosong Sun , Xing Xie

Due to the remarkable capabilities and growing impact of large language models (LLMs), they have been deeply integrated into many aspects of society. Thus, ensuring their alignment with human values and intentions has emerged as a critical…

Large Language Models (LLMs) have emerged as promising solutions for a variety of medical and clinical decision support applications. However, LLMs are often subject to different types of biases, which can lead to unfair treatment of…

Computation and Language · Computer Science 2024-08-23 Raphael Poulain , Hamed Fayyaz , Rahmatollah Beheshti

Integrating language models (LMs) in healthcare systems holds great promise for improving medical workflows and decision-making. However, a critical barrier to their real-world adoption is the lack of reliable evaluation of their…

Computation and Language · Computer Science 2025-12-15 Akash Ghosh , Srivarshinee Sridhar , Raghav Kaushik Ravi , Muhsin Muhsin , Sriparna Saha , Chirag Agarwal

Large language models (LLMs) show significant potential in healthcare, prompting numerous benchmarks to evaluate their capabilities. However, concerns persist regarding the reliability of these benchmarks, which often lack clinical…

Computation and Language · Computer Science 2026-04-30 Wenting Chen , Guo Yu , Yiu-Fai Cheung , Meidan Ding , Jie Liu , Zizhan Ma , Wenxuan Wang , Linlin Shen

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

The alignment of large language models (LLMs) with human values is critical for their safe and effective deployment across diverse user populations. However, existing benchmarks often neglect cultural and demographic diversity, leading to…

Computation and Language · Computer Science 2025-09-17 Yao Liang , Dongcheng Zhao , Feifei Zhao , Guobin Shen , Yuwei Wang , Dongqi Liang , Yi Zeng

The rise of large language models (LLMs) has transformed healthcare by offering clinical guidance, yet their direct deployment to patients poses safety risks due to limited domain expertise. To mitigate this, we propose repositioning LLMs…

Computation and Language · Computer Science 2025-10-14 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Prayag Tiwari , Xiang Wan , Feng Jiang , Benyou Wang

Large language models (LLMs) are increasingly used in human-AI interaction research and practice, yet existing capability and safety benchmarks reveal little about the value priorities these systems express or how those priorities…

Artificial Intelligence · Computer Science 2026-05-19 Gabriel Rongyang Lau , Wei Yan Low , Seow Min Koh , Fiona Fui-Hoon Nah , Andree Hartanto

Large language models (LLMs) are currently aligned using techniques such as reinforcement learning from human feedback (RLHF). However, these methods use scalar rewards that can only reflect user preferences on average. Pluralistic…

Computation and Language · Computer Science 2025-08-13 Jadie Adams , Brian Hu , Emily Veenhuis , David Joy , Bharadwaj Ravichandran , Aaron Bray , Anthony Hoogs , Arslan Basharat

Background: Recent advancements in large language models (LLMs) offer potential benefits in healthcare, particularly in processing extensive patient records. However, existing benchmarks do not fully assess LLMs' capability in handling…

Pluralistic alignment has emerged as a promising approach for ensuring that large language models (LLMs) faithfully represent the diversity, nuance, and conflict inherent in human values. In this work, we study a high-stakes deployment…

Computers and Society · Computer Science 2026-03-10 Rachel Hong , Yael Eiger , Jevan Hutson , Os Keyes , William Agnew

The wide exploration of large language models (LLMs) raises the awareness of alignment between healthcare stakeholder preferences and model outputs. This alignment becomes a crucial foundation to empower the healthcare workflow effectively,…

Computers and Society · Computer Science 2025-05-07 Kexin Ding , Mu Zhou , Akshay Chaudhari , Shaoting Zhang , Dimitris N. Metaxas

Despite strong performance in medical question-answering, the clinical adoption of Large Language Models (LLMs) is critically hampered by their opaque 'black-box' reasoning, limiting clinician trust. This challenge is compounded by the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Chao Ding , Mouxiao Bian , Pengcheng Chen , Hongliang Zhang , Tianbin Li , Lihao Liu , Jiayuan Chen , Zhuoran Li , Yabei Zhong , Yongqi Liu , Haiqing Huang , Dongming Shan , Junjun He , Jie Xu
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