English
Related papers

Related papers: GeLLMO: Generalizing Large Language Models for Mul…

200 papers

Understanding molecules is key to understanding organisms and driving advances in drug discovery, requiring interdisciplinary knowledge across chemistry and biology. Although large molecular language models have achieved notable success in…

Machine Learning · Computer Science 2025-10-03 Dongki Kim , Wonbin Lee , Sung Ju Hwang

Large Language Models (LLMs) have recently developed new advanced functionalities. Their effectiveness relies on statistical learning and generalization capabilities. However, they face limitations in internalizing the data they process and…

Machine Learning · Computer Science 2026-01-14 Farah Ben Slama , Frédéric Armetta

Query optimization is a critical task in database systems, focused on determining the most efficient way to execute a query from an enormous set of possible strategies. Traditional approaches rely on heuristic search methods and cost…

Databases · Computer Science 2025-03-11 Zhiming Yao , Haoyang Li , Jing Zhang , Cuiping Li , Hong Chen

Molecular property prediction (MPP) is a fundamental and crucial task in drug discovery. However, prior methods are limited by the requirement for a large number of labeled molecules and their restricted ability to generalize for unseen and…

Quantitative Methods · Quantitative Biology 2024-10-21 Yuyan Liu , Sirui Ding , Sheng Zhou , Wenqi Fan , Qiaoyu Tan

Large Language Models (LLMs) have made great strides in areas such as language processing and computer vision. Despite the emergence of diverse techniques to improve few-shot learning capacity, current LLMs fall short in handling the…

Biomolecules · Quantitative Biology 2024-05-14 Xianggen Liu , Yan Guo , Haoran Li , Jin Liu , Shudong Huang , Bowen Ke , Jiancheng Lv

Goal-oriented de novo molecule design, namely generating molecules with specific property or substructure constraints, is a crucial yet challenging task in drug discovery. Existing methods, such as Bayesian optimization and reinforcement…

Computational Engineering, Finance, and Science · Computer Science 2025-02-28 Chuanliu Fan , Ziqiang Cao , Zicheng Ma , Nan Yu , Yimin Peng , Jun Zhang , Yiqin Gao , Guohong Fu

Recent advancements in large language models have opened new possibilities for generative molecular drug design. We present Chemlactica and Chemma, two language models fine-tuned on a novel corpus of 110M molecules with computed properties,…

Large Language Models (LLMs) have emerged as powerful tools for automating complex reasoning and decision-making tasks. In telecommunications, they hold the potential to transform network optimization, automate troubleshooting, enhance…

Various deep learning-based approaches utilizing pre-trained language models (PLMs) have been proposed for automated vulnerability detection. With recent advancements in large language models (LLMs), several studies have begun exploring…

Software Engineering · Computer Science 2026-03-11 Honglin Shu , Michael Fu , Junji Yu , Dong Wang , Chakkrit Tantithamthavorn , Junjie Chen , Yasutaka Kamei

Large Language Models (LLMs) have achieved remarkable success across a wide range of natural language tasks, and recent efforts have sought to extend their capabilities to multimodal domains and resource-constrained environments. However,…

Machine Learning · Computer Science 2025-05-26 Yun-Da Tsai

Large language models (LLMs) have revolutionized natural language processing by achieving state-of-the-art performance across various tasks. Recently, their effectiveness as embedding models has gained attention, marking a paradigm shift…

Computation and Language · Computer Science 2025-07-28 Chongyang Tao , Tao Shen , Shen Gao , Junshuo Zhang , Zhen Li , Kai Hua , Wenpeng Hu , Zhengwei Tao , Shuai Ma

Code Pre-trained Models (CodePTMs) based vulnerability detection have achieved promising results over recent years. However, these models struggle to generalize as they typically learn superficial mapping from source code to labels instead…

Cryptography and Security · Computer Science 2024-06-07 Xiaohu Du , Ming Wen , Jiahao Zhu , Zifan Xie , Bin Ji , Huijun Liu , Xuanhua Shi , Hai Jin

Multi-modal Large Language Models (MLLMs) integrate visual and linguistic reasoning to address complex tasks such as image captioning and visual question answering. While MLLMs demonstrate remarkable versatility, MLLMs appears limited…

Computation and Language · Computer Science 2025-03-07 Wenke Huang , Jian Liang , Xianda Guo , Yiyang Fang , Guancheng Wan , Xuankun Rong , Chi Wen , Zekun Shi , Qingyun Li , Didi Zhu , Yanbiao Ma , Ke Liang , Bin Yang , He Li , Jiawei Shao , Mang Ye , Bo Du

Despite a widespread success in various applications, large language models (LLMs) often stumble when tackling basic physical reasoning or executing robotics tasks, due to a lack of direct experience with the physical nuances of the real…

Computation and Language · Computer Science 2024-11-13 Haolan Liu , Jishen Zhao

Designing de-novo molecules with desired property profiles requires efficient exploration of the vast chemical space ranging from $10^{23}$ to $10^{60}$ possible synthesizable candidates. While various deep generative models have been…

Machine Learning · Computer Science 2025-08-25 Kamran Chitsaz , Roshan Balaji , Quentin Fournier , Nirav Pravinbhai Bhatt , Sarath Chandar

Instruction-tuned large language models (LLMs) have demonstrated promising zero-shot generalization capabilities across various downstream tasks. Recent research has introduced multimodal capabilities to LLMs by integrating independently…

Computation and Language · Computer Science 2023-11-29 Utsav Garg , Erhan Bas

With powerful large language models (LLMs) demonstrating superhuman reasoning capabilities, a critical question arises: Do LLMs genuinely reason, or do they merely recall answers from their extensive, web-scraped training datasets? Publicly…

Computation and Language · Computer Science 2025-04-28 Haowei Lin , Xiangyu Wang , Ruilin Yan , Baizhou Huang , Haotian Ye , Jianhua Zhu , Zihao Wang , James Zou , Jianzhu Ma , Yitao Liang

The applications of large language models (LLMs) are promising for biomedical and healthcare research. Despite the availability of open-source LLMs trained using a wide range of biomedical data, current research on the applications of LLMs…

Machine Learning · Computer Science 2024-09-25 Tianyu Liu , Yijia Xiao , Xiao Luo , Hua Xu , W. Jim Zheng , Hongyu Zhao

Molecule discovery plays a crucial role in various scientific fields, advancing the design of tailored materials and drugs. However, most of the existing methods heavily rely on domain experts, require excessive computational cost, or…

Computation and Language · Computer Science 2024-05-10 Jiatong Li , Yunqing Liu , Wenqi Fan , Xiao-Yong Wei , Hui Liu , Jiliang Tang , Qing Li

Large Language Models (LLMs) have demonstrated remarkable capabilities across a variety of software engineering and coding tasks. However, their application in the domain of code and compiler optimization remains underexplored. Training…

Programming Languages · Computer Science 2024-07-04 Chris Cummins , Volker Seeker , Dejan Grubisic , Baptiste Roziere , Jonas Gehring , Gabriel Synnaeve , Hugh Leather