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Molecular dynamics (MD) simulations are a central tool in science and engineering enabling the study of dynamical behavior and the link between microscopic structure and macroscopic function. Their high computational cost, however, has…

Chemical Physics · Physics 2026-01-22 Salman N. Salman , Sergey A. Shteingolts , Ron Levie , Dan Mendels

Machine-learning force fields (MLFFs) have emerged as a promising solution for speeding up ab initio molecular dynamics (MD) simulations, where accurate force predictions are critical but often computationally expensive. In this work, we…

Molecular dynamics (MD) simulates the time evolution of atomic systems governed by interatomic forces, and the fidelity of these simulations depends critically on the underlying force model. Classical force fields (CFFs) rely on fixed…

Performance · Computer Science 2026-03-05 Udari De Alwis , Benjamin E. Mayer , Tom J. Ashby , Maria Barrera , Timon Evenblij , Joyjit Kundu

Recently, machine learning (ML) has been used to address the computational cost that has been limiting ab initio molecular dynamics (AIMD). Here, we present GNNFF, a graph neural network framework to directly predict atomic forces from…

Due to inappropriate sample selection and limited training data, a distribution shift often exists between the training and test sets. This shift can adversely affect the test performance of Graph Neural Networks (GNNs). Existing approaches…

Machine Learning · Computer Science 2023-10-16 Rui Ding , Jielong Yang , Feng Ji , Xionghu Zhong , Linbo Xie

There has been a recent surge of interest in using machine learning to approximate density functional theory (DFT) in materials science. However, many of the most performant models are evaluated on large databases of computed properties of,…

Materials Science · Physics 2021-07-02 Filip Ekström , Rickard Armiento , Fredrik Lindsten

Machine-learned force fields (MLFFs) promise to offer a computationally efficient alternative to ab initio simulations for complex molecular systems. However, ensuring their generalizability beyond training data is crucial for their wide…

Machine Learning · Computer Science 2024-12-24 Shaswat Mohanty , Yifan Wang , Wei Cai

Modern graph neural networks (GNNs) can be sensitive to changes in the input graph structure and node features, potentially resulting in unpredictable behavior and degraded performance. In this work, we introduce a spectral framework known…

Machine Learning · Computer Science 2024-10-11 Wuxinlin Cheng , Chenhui Deng , Ali Aghdaei , Zhiru Zhang , Zhuo Feng

Federated Learning (FL) is a promising paradigm for realizing edge intelligence, allowing collaborative learning among distributed edge devices by sharing models instead of raw data. However, the shared models are often assumed to be ideal,…

Machine Learning · Computer Science 2025-06-02 Dongzi Jin , Yong Xiao , Yingyu Li

Unnormalized probability distributions are central to modeling complex physical systems across various scientific domains. Traditional sampling methods, such as Markov Chain Monte Carlo (MCMC), often suffer from slow convergence, critical…

Machine Learning · Computer Science 2025-10-27 Vikas Kanaujia , Vipul Arora

The performance of graph neural networks (GNNs) is susceptible to discrepancies between training and testing sample distributions. Prior studies have attempted to mitigating the impact of distribution shift by reconstructing node features…

Machine Learning · Computer Science 2025-04-18 Jielong Yang , Rui Ding , Feng Ji , Hongbin Wang , Linbo Xie

Molecular Dynamics (MD) simulation is a powerful tool for understanding the dynamics and structure of matter. Since the resolution of MD is atomic-scale, achieving long time-scale simulations with femtosecond integration is very expensive.…

Machine Learning · Computer Science 2022-04-27 Zijie Li , Kazem Meidani , Prakarsh Yadav , Amir Barati Farimani

Machine learning force fields (MLFFs) are a promising approach to balance the accuracy of quantum mechanics with the efficiency of classical potentials, yet selecting an optimal model amid increasingly diverse architectures that delivers…

Machine Learning · Computer Science 2025-12-09 Bangchen Yin , Yue Yin , Yuda W. Tang , Hai Xiao

Generating stable molecular conformations typically forces a tradeoff between the physical realism of energy-based relaxation and the sampling efficiency of data-driven generative models. While machine learning force fields (MLFFs) can…

Graph Neural Networks (GNN) rely on graph convolutions to learn features from network data. GNNs are stable to different types of perturbations of the underlying graph, a property that they inherit from graph filters. In this paper we…

Machine Learning · Computer Science 2022-02-11 Juan Cervino , Luana Ruiz , Alejandro Ribeiro

Molecular dynamics is a powerful simulation tool to explore material properties. Most of the realistic material systems are too large to be simulated with first-principles molecular dynamics. Classical molecular dynamics has lower…

Computational Physics · Physics 2021-01-11 Zun Wang , Chong Wang , Sibo Zhao , Shiqiao Du , Yong Xu , Bing-Lin Gu , Wenhui Duan

We explore the potential of Graph Neural Networks (GNNs) to improve the performance of high-dimensional effective field theory parameter fits to collider data beyond traditional rectangular cut-based differential distribution analyses. In…

High Energy Physics - Phenomenology · Physics 2022-05-11 Oliver Atkinson , Akanksha Bhardwaj , Stephen Brown , Christoph Englert , David J. Miller , Panagiotis Stylianou

Analyzing the stability of graph neural networks (GNNs) under topological perturbations is key to understanding their transferability and the role of each architecture component. However, stability has been investigated only for particular…

Signal Processing · Electrical Eng. & Systems 2023-12-06 Zhan Gao , Amanda Prorok , Elvin Isufi

Molecular dynamics (MD) simulation is essential for various scientific domains but computationally expensive. Learning-based force fields have made significant progress in accelerating ab-initio MD simulation but are not fast enough for…

Machine Learning · Computer Science 2023-08-29 Xiang Fu , Tian Xie , Nathan J. Rebello , Bradley D. Olsen , Tommi Jaakkola

Data-driven modeling approaches can produce fast surrogates to study large-scale physics problems. Among them, graph neural networks (GNNs) that operate on mesh-based data are desirable because they possess inductive biases that promote…

Machine Learning · Computer Science 2023-04-04 Brian R. Bartoldson , Yeping Hu , Amar Saini , Jose Cadena , Yucheng Fu , Jie Bao , Zhijie Xu , Brenda Ng , Phan Nguyen
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