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Parkinson's Disease (PD) is one of the most prevalent neurodegenerative diseases that affects tens of millions of Americans. PD is highly progressive and heterogeneous. Quite a few studies have been conducted in recent years on predictive…

Computer Vision and Pattern Recognition · Computer Science 2019-05-08 Xi Sheryl Zhang , Lifang He , Kun Chen , Yuan Luo , Jiayu Zhou , Fei Wang

The study involved 56 patients with advanced and late stages of Parkinsons disease, which could be considered as potentially requiring neurosurgical treatment-electrical stimulation of deep brain structures. An algorithm has been developed…

Neurons and Cognition · Quantitative Biology 2021-11-10 Elcin Huseyn

Conventional deep brain stimulation (DBS) of basal ganglia uses high-frequency regular electrical pulses to treat Parkinsonian motor symptoms and has a series of limitations. Relatively new and not yet clinically tested optogenetic…

Neurons and Cognition · Quantitative Biology 2021-04-26 Shivakeshavan Ratnadurai-Giridharan , Chung Cheung , Leonid Rubchinsky

Parkinsons disease (PD) is a movement disorder and the second most common neurodengerative disease but despite its relative abundance, there are no clinically accepted neuroimaging biomarkers to make prognostic predictions or differentiate…

Neurons and Cognition · Quantitative Biology 2022-06-23 Cooper J. Mellema , Kevin P. Nguyen , Alex Treacher , Aixa Andrade Hernandez , Albert A. Montillo

Parkinson's disease (PD) is projected to increase substantially due to population aging, making early diagnosis increasingly important, as timely detection may delay progression and reduce long-term complications. Retinal microvasculature…

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder where motor dysfunction gradually increases as the disease progress. In addition to administering dopaminergic PD-specific drugs, attending neurologists strongly…

Computers and Society · Computer Science 2015-11-10 Ioannis Pachoulakis , Nikolaos Papadopoulos , Cleanthe Spanaki

Parkinson's disease (PD) is a slowly progressing neurodegenerative disease with early manifestation of motor signs. Recently, there has been a growing interest in developing automatic tools that can assess motor function in PD patients.…

Information Retrieval · Computer Science 2018-05-04 Liron Allerhand , Brit Youngmann , Elad Yom-Tov , David Arkadir

Deep brain stimulation (DBS) is a neurosurgical procedure successfully used to treat conditions such as Parkinson's disease. Electrostimulation, carried out by implanting electrodes into an identified focus in the brain, makes it possible…

Signal Processing · Electrical Eng. & Systems 2023-08-23 Arkadiusz Nowacki , Ewelina Kołpa , Mateusz Szychiewicz , Konrad Ciecierski

Resting-state EEG (rs-EEG) has been demonstrated to aid in Parkinson's disease (PD) diagnosis. In particular, the power spectral density (PSD) of low-frequency bands ({\delta} and {\theta}) and high-frequency bands ({\alpha} and \b{eta})…

Signal Processing · Electrical Eng. & Systems 2023-03-03 Anna Kurbatskaya , Alberto Jaramillo-Jimenez , John Fredy Ochoa-Gomez , Kolbjørn Brønnick , Alvaro Fernandez-Quilez

In the past few years, there are several researches on Parkinson's disease (PD) recognition using single-photon emission computed tomography (SPECT) images with deep learning (DL) approach. However, the DL model's complexity usually results…

Image and Video Processing · Electrical Eng. & Systems 2021-05-05 Theerasarn Pianpanit , Sermkiat Lolak , Phattarapong Sawangjai , Thapanun Sudhawiyangkul , Theerawit Wilaiprasitporn

Multiscale modelling presents a multifaceted perspective into understanding the mechanisms of the brain and how neurodegenerative disorders like Parkinson's disease (PD) manifest and evolve over time. In this study, we propose a novel…

Neurons and Cognition · Quantitative Biology 2025-09-18 Aaron Herrera , Hina Shaheen

Decoding motor performance from brain signals offers promising avenues for adaptive deep brain stimulation (aDBS) for Parkinson's disease (PD). In a two-center cohort of 19 PD patients executing a drawing task, we decoded motor performance…

Parkinsons disease (PD) diagnosis is challenging due to subtle early clinical signs. F-DOPA PET is commonly used for early PD diagnosis. We explore the potential of machine-learning (ML) based EEG features extracted from single-channel EEG…

Neurons and Cognition · Quantitative Biology 2023-08-08 Lior Molcho , Neta B. Maimon , Neomi Hezi , Talya Zeimer , Nathan Intrator , Tanya Gurevich

Parkinson's disease (PD) is a prevalent neurodegenerative disorder known for its impact on motor neurons, causing symptoms like tremors, stiffness, and gait difficulties. This study explores the potential of vocal feature alterations in PD…

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuron loss and the accumulation of abnormal synuclein. PD presents both motor and non-motor symptoms that progressively impair…

Machine Learning · Computer Science 2025-04-07 Masahiro Matsumoto , Abu Saleh Musa Miah , Nobuyoshi Asai , Jungpil Shin

Parkinson's Disease (PD) is a neurodegenerative disorder that significantly impacts motor and non-motor functions. There is currently no treatment that slows or stops neurodegeneration in PD. In this context, assistive technologies (ATs)…

Human-Computer Interaction · Computer Science 2025-05-27 Subek Acharya , Sansrit Paudel

Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by the death of dopaminergic neurons, leading to various movement disorder symptoms. Early diagnosis of PD is crucial to prevent adverse effects, yet…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Nabil Daiyan , Md Rakibul Haque

This paper presents the design of a wireless sensor network for detecting and alerting the freezing of gait (FoG) symptoms in patients with Parkinson's disease. Three sensor nodes, each integrating a 3-axis accelerometer, can be placed on a…

Signal Processing · Electrical Eng. & Systems 2022-12-02 Ourong Lin , Tian Yu , Yuhan Hou , Yi Zhu , Xilin Liu

Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system characterized by motor and non-motor symptoms. As the disease progresses, patients alternate periods in which motor symptoms are mitigated due to…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-26 Anna Pompili , Rubén Solera-Ureña , Alberto Abad , Rita Cardoso , Isabel Guimarães , Margherita Fabbri , Isabel P. Martins , Joaquim Ferreira

Parkinson's Disease (PD) is a neurodegenerative disease that currently does not have a cure. In order to facilitate disease management and reduce the speed of symptom progression, early diagnosis is essential. The current clinical,…

Image and Video Processing · Electrical Eng. & Systems 2019-09-11 Justin Quan , Lin Xu , Rene Xu , Tyrael Tong , Jean Su