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Understanding how cortical activity represents natural whole-body behaviors in primates remains challenging. Limited by the diversity of movements and inaccessibility of large-scale neural representation of whole-body kinematics, previous…

Machine Learning · Computer Science 2026-05-29 Jieshi He , Puzhe Li , Yanan Sui , Mu-ming Poo

We and others have previously developed brain-machine-interfaces (BMIs), which allowed ensembles of cortical neurons to control artificial limbs (1-4). However, it is unclear whether cortical ensembles could operate a BMI for whole-body…

Neurons and Cognition · Quantitative Biology 2015-04-13 Sankaranarayani Rajangam , Po-He Tseng , Allen Yin , Mikhail A. Lebedev , Miguel A. L. Nicolelis

Uncovering the fundamental neural correlates of biological intelligence, developing mathematical models, and conducting computational simulations are critical for advancing new paradigms in artificial intelligence (AI). In this study, we…

Neural and Evolutionary Computing · Computer Science 2024-09-05 Jie Su , Fang Cai , Shu-Kuo Zhao , Xin-Yi Wang , Tian-Yi Qian , Da-Hui Wang , Bo Hong

Multi-view learning improves the learning performance by utilizing multi-view data: data collected from multiple sources, or feature sets extracted from the same data source. This approach is suitable for primate brain state decoding using…

Neurons and Cognition · Quantitative Biology 2020-07-06 Zhenhua Shi , Xiaomo Chen , Changming Zhao , He He , Veit Stuphorn , Dongrui Wu

A major hurdle to clinical translation of brain-machine interfaces (BMIs) is that current decoders, which are trained from a small quantity of recent data, become ineffective when neural recording conditions subsequently change. We tested…

Neurons and Cognition · Quantitative Biology 2016-12-15 David Sussillo , Sergey D. Stavisky , Jonathan C. Kao , Stephen I. Ryu , Krishna V. Shenoy

Objective. In this paper, we consider the problem of cross-subject decoding, where neural activity data collected from the prefrontal cortex of a given subject (destination) is used to decode motor intentions from the neural activity of a…

Neural and Evolutionary Computing · Computer Science 2022-02-23 Marko Angjelichinoski , Bijan Pesaran , Vahid Tarokh

Understanding how the primate brain transforms complex visual scenes into coherent perceptual experiences remains a central challenge in neuroscience. Here, we present a comprehensive framework for interpreting monkey visual processing by…

Neurons and Cognition · Quantitative Biology 2025-10-10 Teng Fei , Srinivas Ravishankar , Hoko Nakada , Abhinav Uppal , Ian Jackson , Garrison W. Cottrell , Ryusuke Hayashi , Virginia R. de Sa

A brain--machine interface (BMI) based on motor imagery (MI) enables the control of devices using brain signals while the subject imagines performing a movement. It plays a vital role in prosthesis control and motor rehabilitation. To…

Signal Processing · Electrical Eng. & Systems 2024-09-20 Xiaying Wang , Michael Hersche , Michele Magno , Luca Benini

Understanding how neural activity gives rise to perception is a central challenge in neuroscience. We address the problem of decoding visual information from high-density intracortical recordings in primates, using the THINGS Ventral Stream…

Neurons and Cognition · Quantitative Biology 2026-01-19 Matteo Ciferri , Matteo Ferrante , Nicola Toschi

Accurate and robust recording and decoding from the central nervous system (CNS) is essential for advances in human-machine interfacing. However, technologies used to directly measure CNS activity are limited by their resolution,…

Neurons and Cognition · Quantitative Biology 2025-09-19 Jaime Ibáñez , Blanka Zicher , Etienne Burdet , Stuart N. Baker , Carsten Mehring , Dario Farina

In this work, the control of snake robot locomotion via economic model predictive control (MPC) is studied. Only very few examples of applications of MPC to snake robots exist and rigorous proofs for recursive feasibility and convergence…

Systems and Control · Electrical Eng. & Systems 2021-11-03 Marko Nonhoff , Philipp N. Köhler , Anna M. Kohl , Kristin Y. Pettersen , Frank Allgöwer

Brain stimulation is a powerful tool for understanding cortical function and holds promise for therapeutic interventions in neuropsychiatric disorders. Initial visual prosthetics apply electric microstimulation to early visual cortex which…

Neurons and Cognition · Quantitative Biology 2025-10-07 Johannes Mehrer , Ben Lonnqvist , Anna Mitola , Abdulkadir Gokce , Paolo Papale , Martin Schrimpf

Reading emotions precisely from segments of neural activity is crucial for the development of emotional brain-computer interfaces. Among all neural decoding algorithms, deep learning (DL) holds the potential to become the most promising…

Human-Computer Interaction · Computer Science 2023-03-09 Xinming Wu , Ji Dai

In this study, we adopted visual motion imagery, which is a more intuitive brain-computer interface (BCI) paradigm, for decoding the intuitive user intention. We developed a 3-dimensional BCI training platform and applied it to assist the…

Signal Processing · Electrical Eng. & Systems 2020-05-19 Byoung-Hee Kwon , Ji-Hoon Jeong , Jeong-Hyun Cho , Seong-Whan Lee

This paper presents an efficient deep learning solution for decoding motor movements from neural recordings in non-human primates. An Autoencoder Gated Recurrent Unit (AEGRU) model was adopted as the model architecture for this task. The…

Signal Processing · Electrical Eng. & Systems 2024-11-04 Yuanxi Wang , Zuowen Wang , Shih-Chii Liu

Ankle exoskeletons have garnered considerable interest for their potential to enhance mobility and reduce fall risks, particularly among the aging population. The efficacy of these devices relies on accurate real-time prediction of the…

Systems and Control · Electrical Eng. & Systems 2024-11-26 Silas Ruhrberg Estévez , Josée Mallah , Dominika Kazieczko , Chenyu Tang , Luigi G. Occhipinti

The hand, a complex effector comprising dozens of degrees of freedom of movement, endows us with the ability to flexibly, precisely, and effortlessly interact with objects. The neural signals associated with dexterous hand movements in…

Neurons and Cognition · Quantitative Biology 2019-06-21 Elizaveta V. Okorokova , James M. Goodman , Nicholas G. Hatsopoulos , Sliman J. Bensmaia

We present Model-Predictive Interaction Primitives -- a robot learning framework for assistive motion in human-machine collaboration tasks which explicitly accounts for biomechanical impact on the human musculoskeletal system. First, we…

Robotics · Computer Science 2020-11-16 Geoffrey Clark , Joseph Campbell , Heni Ben Amor

Deep convolutional neural networks (CNNs) have structures that are loosely related to that of the primate visual cortex. Surprisingly, when these networks are trained for object classification, the activity of their early, intermediate, and…

Neurons and Cognition · Quantitative Biology 2016-10-18 Omid Rezai , Pinar Boyraz Jentsch , Bryan Tripp

Progress has led to a detailed understanding of the neural mechanisms that underlie decision making in primates. However, less is known about why such mechanisms are present in the first place. Theory suggests that primate decision making…

Neurons and Cognition · Quantitative Biology 2026-01-21 Nathan J. Wispinski , Scott A. Stone , Anthony Singhal , Patrick M. Pilarski , Craig S. Chapman
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