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Enhancing accurate molecular property prediction relies on effective and proficient representation learning. It is crucial to incorporate diverse molecular relationships characterized by multi-similarity (self-similarity and relative…

Machine Learning · Computer Science 2024-02-05 Hao Xu , Zhengyang Zhou , Pengyu Hong

The recent emergence of contrastive learning approaches facilitates the application on graph representation learning (GRL), introducing graph contrastive learning (GCL) into the literature. These methods contrast semantically similar and…

Machine Learning · Computer Science 2022-06-03 Ganqu Cui , Yufeng Du , Cheng Yang , Jie Zhou , Liang Xu , Xing Zhou , Xingyi Cheng , Zhiyuan Liu

Graph representation learning (GRL) makes considerable progress recently, which encodes graphs with topological structures into low-dimensional embeddings. Meanwhile, the time-consuming and costly process of annotating graph labels manually…

Machine Learning · Computer Science 2024-02-28 Haojun Jiang , Jiawei Sun , Jie Li , Chentao Wu

Advancements in technologies related to working with omics data require novel computation methods to fully leverage information and help develop a better understanding of human diseases. This paper studies the effects of introducing graph…

Genomics · Quantitative Biology 2023-10-17 Nishant Rajadhyaksha , Aarushi Chitkara

Graph contrastive learning (GCL) has recently emerged as a new concept which allows for capitalizing on the strengths of graph neural networks (GNNs) to learn rich representations in a wide variety of applications which involve abundant…

Machine Learning · Computer Science 2024-06-26 Yuzhou Chen , Jose Frias , Yulia R. Gel

Federated graph learning (FGL) has emerged as a promising paradigm for collaborative graph representation learning, enabling multiple parties to jointly train models while preserving data privacy. However, most existing approaches assume…

Machine Learning · Computer Science 2026-01-01 Zhengyu Wu , Guang Zeng , Huilin Lai , Daohan Su , Jishuo Jia , Yinlin Zhu , Xunkai Li , Rong-Hua Li , Guoren Wang , Chenghu Zhou

Cross-modal contrastive distillation has recently been explored for learning effective 3D representations. However, existing methods focus primarily on modality-shared features, neglecting the modality-specific features during the…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Yifan Zhang , Junhui Hou

Graph Contrastive Learning (GCL) is a widely adopted approach in self-supervised graph representation learning, applying contrastive objectives to produce effective representations. However, current GCL methods primarily focus on capturing…

Machine Learning · Computer Science 2025-07-11 Dongxiao He , Yongqi Huang , Jitao Zhao , Xiaobao Wang , Zhen Wang

Graph Contrastive Learning (GCL) has emerged as a prominent framework for unsupervised graph representation learning. However, relying on augmentation design alone to define the invariances learned by GCL can be brittle under structural…

Machine Learning · Computer Science 2026-04-30 Mengyang Zhao , Longlong Li , Cunquan Qu

Recently, hyperbolic space has risen as a promising alternative for semi-supervised graph representation learning. Many efforts have been made to design hyperbolic versions of neural network operations. However, the inspiring geometric…

Machine Learning · Computer Science 2022-01-24 Jiahong Liu , Menglin Yang , Min Zhou , Shanshan Feng , Philippe Fournier-Viger

Synthetic polymers are versatile and widely used materials. Similar to small organic molecules, a large chemical space of such materials is hypothetically accessible. Computational property prediction and virtual screening can accelerate…

Machine Learning · Computer Science 2022-10-13 Matteo Aldeghi , Connor W. Coley

The prediction of molecular properties is a crucial task in the field of material and drug discovery. The potential benefits of using deep learning techniques are reflected in the wealth of recent literature. Still, these techniques are…

Machine Learning · Computer Science 2023-09-06 Minghao Guo , Veronika Thost , Samuel W Song , Adithya Balachandran , Payel Das , Jie Chen , Wojciech Matusik

Molecular graph representation learning is widely used in chemical and biomedical research. While pre-trained 2D graph encoders have demonstrated strong performance, they overlook the rich molecular domain knowledge associated with…

Machine Learning · Computer Science 2025-10-09 Xingtong Yu , Chang Zhou , Xinming Zhang , Yuan Fang

In this paper, we consider the problem of disease diagnosis. Unlike the conventional learning paradigm that treats labels independently, we propose a knowledge-enhanced framework, that enables training visual representation with the…

Computer Vision and Pattern Recognition · Computer Science 2023-02-28 Chaoyi Wu , Xiaoman Zhang , Yanfeng Wang , Ya Zhang , Weidi Xie

Molecules with identical graph connectivity can exhibit different physical and biological properties if they exhibit stereochemistry-a spatial structural characteristic. However, modern neural architectures designed for learning…

Quantitative Methods · Quantitative Biology 2020-12-07 Lagnajit Pattanaik , Octavian-Eugen Ganea , Ian Coley , Klavs F. Jensen , William H. Green , Connor W. Coley

Quantum-classical Hybrid Machine Learning (QHML) models are recognized for their robust performance and high generalization ability even for relatively small datasets. These qualities offer unique advantages for anti-cancer drug response…

Machine Learning · Computer Science 2025-05-16 Takafumi Ito , Lysenko Artem , Tatsuhiko Tsunoda

Knowledge components (KCs) are the fundamental units of knowledge in the field of education. A KC graph illustrates the relationships and dependencies between KCs. An accurate KC graph can assist educators in identifying the root causes of…

Machine Learning · Computer Science 2025-05-21 Yuan-Hao Jiang , Kezong Tang , Zi-Wei Chen , Yuang Wei , Tian-Yi Liu , Jiayi Wu

Multifold observations are common for different data modalities, e.g., a 3D shape can be represented by multi-view images and an image can be described with different captions. Existing cross-modal contrastive representation learning…

Computer Vision and Pattern Recognition · Computer Science 2023-03-22 Ye Wang , Bowei Jiang , Changqing Zou , Rui Ma

Structure-based drug discovery faces the dual challenge of accurately capturing 3D protein-ligand interactions while navigating ultra-large chemical spaces to identify synthetically accessible candidates. In this work, we present a unified…

Machine Learning · Computer Science 2026-04-22 Carles Navarro , Philipp Tholke , Gianni de Fabritiis

Predicating macroscopic influences of drugs on human body, like efficacy and toxicity, is a central problem of small-molecule based drug discovery. Molecules can be represented as an undirected graph, and we can utilize graph convolution…

Machine Learning · Computer Science 2017-09-19 Junying Li , Deng Cai , Xiaofei He