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This work presents a procedure to extract morphological information from neuronal cells based on the variation of shape functionals as the cell geometry undergoes a dilation through a wide interval of spatial scales. The targeted shapes are…

Identification and counting of cells and mitotic figures is a standard task in diagnostic histopathology. Due to the large overall cell count on histological slides and the potential sparse prevalence of some relevant cell types or mitotic…

Computer Vision and Pattern Recognition · Computer Science 2017-09-08 Marc Aubreville , Maximilian Krappmann , Christof Bertram , Robert Klopfleisch , Andreas Maier

The prospect of neural reconstruction from Electron Microscopy (EM) images has been elucidated by the automatic segmentation algorithms. Although segmentation algorithms eliminate the necessity of tracing the neurons by hand, significant…

Computer Vision and Pattern Recognition · Computer Science 2015-09-29 Toufiq Parag

A major prerequisite for the application of machine learning models in clinical decision making is trust and interpretability. Current explainability studies in the neuroimaging community have mostly focused on explaining individual…

Computer Vision and Pattern Recognition · Computer Science 2022-03-25 Fabian Eitel , Anna Melkonyan , Kerstin Ritter

Due to the rapid innovation of technology and the desire to find and employ biomarkers for neurodegenerative disease, high-dimensional data classification problems are routinely encountered in neuroimaging studies. To avoid over-fitting and…

Machine Learning · Statistics 2018-06-19 Shan Shi , Farouk Nathoo

As proteins with similar structures often have similar functions, analysis of protein structures can help predict protein functions and is thus important. We consider the problem of protein structure classification, which computationally…

Machine Learning · Statistics 2019-10-08 Hongyu Guo , Khalique Newaz , Scott Emrich , Tijana Milenkovic , Jun Li

Recent advances in cancer research largely rely on new developments in microscopic or molecular profiling techniques offering high level of detail with respect to either spatial or molecular features, but usually not both. Here, we present…

Many neuroscientific applications require robust and accurate localization of neurons. It is still an unsolved problem because of the enormous variation in intensity, texture, spatial overlap, morphology and background artifacts. In…

Quantitative Methods · Quantitative Biology 2021-03-22 Tamal Batabyal , Aijaz Ahmad Naik , Daniel Weller , Jaideep Kapur

There is a growing body of work that leverages features extracted via topological data analysis to train machine learning models. While this field, sometimes known as topological machine learning (TML), has seen some notable successes, an…

Machine Learning · Computer Science 2022-11-16 Sarah McGuire , Shane Jackson , Tegan Emerson , Henry Kvinge

Feature extraction is a method of capturing visual content of an image. The feature extraction is the process to represent raw image in its reduced form to facilitate decision making such as pattern classification. We have tried to address…

Computer Vision and Pattern Recognition · Computer Science 2012-08-13 V. P. Gladis Pushpa Rathi , S. Palani

Deep learning methods have recently made notable advances in the tasks of classification and representation learning. These tasks are important for brain imaging and neuroscience discovery, making the methods attractive for porting to a…

Neural and Evolutionary Computing · Computer Science 2014-02-20 Sergey M. Plis , Devon R. Hjelm , Ruslan Salakhutdinov , Vince D. Calhoun

The majority of computer vision algorithms fail to find higher-order (abstract) patterns in an image so are not robust against adversarial attacks, unlike human lateralized vision. Deep learning considers each input pixel in a homogeneous…

Computer Vision and Pattern Recognition · Computer Science 2023-01-31 Abubakar Siddique , Will N. Browne , Gina M. Grimshaw

Deep learning, as a promising new area of machine learning, has attracted a rapidly increasing attention in the field of medical imaging. Compared to the conventional machine learning methods, deep learning requires no hand-tuned feature…

Quantitative Methods · Quantitative Biology 2016-11-29 He Yang , Hengyong Yu , Ge Wang

The morphological classification of radio sources is important to gain a full understanding of galaxy evolution processes and their relation with local environmental properties. Furthermore, the complex nature of the problem, its appeal for…

Astrophysics of Galaxies · Physics 2021-02-09 Burger Becker , Mattia Vaccari , Matthew Prescott , Trienko Lups Grobler

Segmentation of focal (localized) brain pathologies such as brain tumors and brain lesions caused by multiple sclerosis and ischemic strokes are necessary for medical diagnosis, surgical planning and disease development as well as other…

Computer Vision and Pattern Recognition · Computer Science 2017-01-25 Mohammad Havaei , Nicolas Guizard , Hugo Larochelle , Pierre-Marc Jodoin

Prediction of image memorability has attracted interest in various fields. Consequently, the prediction accuracy of convolutional neural network (CNN) models has been approaching the empirical upper bound estimated based on human…

Computer Vision and Pattern Recognition · Computer Science 2023-07-18 Takumi Harada , Hiroyuki Sakai

Deep learning algorithms offer a powerful means to automatically analyze the content of medical images. However, many biological samples of interest are primarily transparent to visible light and contain features that are difficult to…

Computer Vision and Pattern Recognition · Computer Science 2017-09-22 Roarke Horstmeyer , Richard Y. Chen , Barbara Kappes , Benjamin Judkewitz

High-resolution microscopy images of tissue specimens provide detailed information about the morphology of normal and diseased tissue. Image analysis of tissue morphology can help cancer researchers develop a better understanding of cancer…

Recently, over-parameterized neural networks have been extensively analyzed in the literature. However, the previous studies cannot satisfactorily explain why fully trained neural networks are successful in practice. In this paper, we…

Machine Learning · Computer Science 2019-10-28 Cong Fang , Hanze Dong , Tong Zhang

A critical factor that influences the success of an in-vitro fertilization (IVF) procedure is the quality of the transferred embryo. Embryo morphology assessments, conventionally performed through manual microscopic analysis suffer from…

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