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Deep image prior (DIP) has been successfully applied to positron emission tomography (PET) image restoration, enabling represent implicit prior using only convolutional neural network architecture without training dataset, whereas the…

Due to various physical degradation factors and limited counts received, PET image quality needs further improvements. The denoising diffusion probabilistic models (DDPM) are distribution learning-based models, which try to transform a…

Objective Positron emission tomography (PET) allows imaging of patho-physiological information as a form of rate constants from a dynamic image. The rate constant image(s) may be affected from noise on the dynamic image. We introduced an…

Deep image prior (DIP) is an unsupervised deep learning framework that has been successfully applied to a variety of inverse imaging problems. However, DIP-based methods are inherently prone to overfitting, which leads to performance…

In PET, the amount of relative (signal-dependent) noise present in different body regions can be significantly different and is inherently related to the number of counts present in that region. The number of counts in a region depends, in…

Deep image prior (DIP) serves as a good inductive bias for diverse inverse problems. Among them, denoising is known to be particularly challenging for the DIP due to noise fitting with the requirement of an early stopping. To address the…

We study the effect of incorporating self-supervised denoising as a pre-processing step for training deep learning (DL) based reconstruction methods on data corrupted by Gaussian noise. K-space data employed for training are typically…

Dynamic computed tomography perfusion (CTP) imaging is a promising approach for acute ischemic stroke diagnosis and evaluation. Hemodynamic parametric maps of cerebral parenchyma are calculated from repeated CT scans of the first pass of…

Most of the Deep Neural Networks (DNNs) based CT image denoising literature shows that DNNs outperform traditional iterative methods in terms of metrics such as the RMSE, the PSNR and the SSIM. In many instances, using the same metrics, the…

As PET imaging is accompanied by substantial radiation exposure and cancer risk, reducing radiation dose in PET scans is an important topic. However, low-count PET scans often suffer from high image noise, which can negatively impact image…

Recently, convolutional neural network (CNN)-based methods are proposed for hyperspectral images (HSIs) denoising. Among them, unsupervised methods such as the deep image prior (DIP) have received much attention because these methods do not…

Recently, tremendous human-designed and automatically searched neural networks have been applied to image denoising. However, previous works intend to handle all noisy images in a pre-defined static network architecture, which inevitably…

This study aimed to propose a denoising method for dynamic contrast-enhanced computed tomography (DCE-CT) perfusion studies using a three-dimensional deep image prior (DIP), and to investigate its usefulness in comparison with total…

Achieving high image quality for temporal frames in dynamic positron emission tomography (PET) is challenging due to the limited statistic especially for the short frames. Recent studies have shown that deep learning (DL) is useful in a…

Low dose computed tomography (LDCT) is desirable for both diagnostic imaging and image guided interventions. Denoisers are openly used to improve the quality of LDCT. Deep learning (DL)-based denoisers have shown state-of-the-art…

Although supervised convolutional neural networks (CNNs) often outperform conventional alternatives for denoising positron emission tomography (PET) images, they require many low- and high-quality reference PET image pairs. Herein, we…

Low-dose Positron Emission Tomography (PET) imaging presents a significant challenge due to increased noise and reduced image quality, which can compromise its diagnostic accuracy and clinical utility. Denoising diffusion probabilistic…

The deep image prior (DIP) is a well-established unsupervised deep learning method for image reconstruction; yet it is far from being flawless. The DIP overfits to noise if not early stopped, or optimized via a regularized objective. We…

A deep convolutional neural network has been developed to denoise atomic-resolution TEM image datasets of nanoparticles acquired using direct electron counting detectors, for applications where the image signal is severely limited by shot…

Increasing use of CT in modern medical practice has raised concerns over associated radiation dose. Reduction of radiation dose associated with CT can increase noise and artifacts, which can adversely affect diagnostic confidence. Denoising…