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Automated white blood cell (WBC) classification is essential for leukemia screening but remains challenged by extreme class imbalance, long-tail distributions, and domain shift, leading deep models to overfit dominant classes and fail on…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Duc T. Nguyen , Hoang-Long Nguyen , Huy-Hieu Pham

This paper presents a novel approach to accurately classify the hallmarks of cancer, which is a crucial task in cancer research. Our proposed method utilizes the Bidirectional Encoder Representations from Transformers (BERT) architecture,…

Computation and Language · Computer Science 2023-06-08 Sultan Zavrak , Seyhmus Yilmaz

Machine learning has endless applications in the health care industry. White blood cell classification is one of the interesting and promising area of research. The classification of the white blood cells plays an important part in the…

Computer Vision and Pattern Recognition · Computer Science 2021-12-14 Nalla Praveen , Narinder Singh Punn , Sanjay Kumar Sonbhadra , Sonali Agarwal , M. Syafrullah , Krisna Adiyarta

Swift and accurate blood smear analysis is an effective diagnostic method for leukemia and other hematological malignancies. However, manual leukocyte count and morphological evaluation using a microscope is time-consuming and prone to…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Chandravardhan Singh Raghaw , Arnav Sharma , Shubhi Bansal , Mohammad Zia Ur Rehman , Nagendra Kumar

This research paper focuses on Acute Lymphoblastic Leukemia (ALL), a form of blood cancer prevalent in children and teenagers, characterized by the rapid proliferation of immature white blood cells (WBCs). These atypical cells can overwhelm…

Computer Vision and Pattern Recognition · Computer Science 2023-12-04 Wahidul Hasan Abir , Md. Fahim Uddin , Faria Rahman Khanam , Mohammad Monirujjaman Khan

Tumor heterogeneity is a challenge to designing effective and targeted therapies. Glioma-type identification depends on specific molecular and histological features, which are defined by the official WHO classification CNS. These guidelines…

Applications · Statistics 2023-05-23 Roberta Coletti , Mónica L. Mendonça , Susana Vinga , Marta B. Lopes

Melanoma is the most lethal form of skin cancer, with an increasing incidence rate worldwide. Analyzing histological images of melanoma by localizing and classifying tissues and cell nuclei is considered the gold standard method for…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Nima Torbati , Anastasia Meshcheryakova , Ramona Woitek , Sepideh Hatamikia , Diana Mechtcheriakova , Amirreza Mahbod

Acute lymphoblastic leukemia (ALL) severity is determined by the presence and ratios of blast cells (abnormal white blood cells) in both bone marrow and peripheral blood. Manual diagnosis of this disease is a tedious and time-consuming…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Amir Masoud Rahmani , Parisa Khoshvaght , Hamid Alinejad-Rokny , Samira Sadeghi , Parvaneh Asghari , Zohre Arabi , Mehdi Hosseinzadeh

Leukemia, a severe form of blood cancer, claims thousands of lives each year. This study focuses on the detection of Acute Lymphoblastic Leukemia (ALL) using advanced image processing and deep learning techniques. By leveraging recent…

Computer Vision and Pattern Recognition · Computer Science 2025-01-14 Alaa Awad , Salah A. Aly

Automating white blood cell classification for diagnosis of leukaemia is a promising alternative to time-consuming and resource-intensive examination of cells by expert pathologists. However, designing robust algorithms for classification…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Siddharth Srivastava , Adam Smith , Scott Brooks , Jack Bacon , Till Bretschneider

The Internet of Things (IoT) is a concept by which objects find identity and can communicate with each other in a network. One of the applications of the IoT is in the field of medicine, which is called the Internet of Medical Things…

Machine Learning · Computer Science 2025-12-19 Shabnam Bagheri Marzijarani , Mohammad Zolfaghari , Hedieh Sajedi

Acute lymphoblastic leukemia (ALL) is a prevalent hematological malignancy in both pediatric and adult populations. Early and accurate detection with precise subtyping is essential for guiding therapy. Conventional workflows are complex,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Md. Maruf , Md. Mahbubul Haque , Bishowjit Paul

The classification of white blood cells (WBCs) from peripheral blood smears is critical for the diagnosis of leukemia. However, automated approaches still struggle due to challenges including class imbalance, domain shift, and morphological…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Antony Gitau , Martin Paulson , Bjørn-Jostein Singstad , Karl Thomas Hjelmervik , Ola Marius Lysaker , Veralia Gabriela Sanchez

Cancer and its subtypes constitute approximately 30% of all causes of death globally and display a wide range of heterogeneity in terms of clinical and molecular responses to therapy. Molecular subtyping has enabled the use of precision…

Quantitative Methods · Quantitative Biology 2024-07-11 Anwar Khan , Boreom Lee

Blood cell classification and counting are vital for the diagnosis of various blood-related diseases, such as anemia, leukemia, and thrombocytopenia. The manual process of blood cell classification and counting is time-consuming, prone to…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Sohag Kumar Mondal , Md. Simul Hasan Talukder , Mohammad Aljaidi , Rejwan Bin Sulaiman , Md Mohiuddin Sarker Tushar , Amjad A Alsuwaylimi

Earlier diagnosis of Leukemia can save thousands of lives annually. The prognosis of leukemia is challenging without the morphological information of White Blood Cells (WBC) and relies on the accessibility of expensive microscopes and the…

Image and Video Processing · Electrical Eng. & Systems 2024-05-20 Abdul Rehman , Talha Meraj , Aiman Mahmood Minhas , Ayisha Imran , Mohsen Ali , Waqas Sultani

Developing nations lack adequate number of hospitals with modern equipment and skilled doctors. Hence, a significant proportion of these nations' population, particularly in rural areas, is not able to avail specialized and timely…

Computer Vision and Pattern Recognition · Computer Science 2020-03-20 Shubham Goswami , Suril Mehta , Dhruva Sahrawat , Anubha Gupta , Ritu Gupta

Acute Lymphoblastic Leukemia (ALL) is one of the most common types of childhood blood cancer. The quick start of the treatment process is critical to saving the patient's life, and for this reason, early diagnosis of this disease is…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Amirhossein Askari Farsangi , Ali Sharifi-Zarchi , Mohammad Hossein Rohban

Leukemia epitomizes the class of highly complex diseases that new technologies aim to tackle by using large sets of single-cell level information. Achieving such goal depends critically not only on experimental techniques but also on…

Quantitative Methods · Quantitative Biology 2014-06-02 Jose M. G. Vilar

Cancer is a leading cause of death in many countries. An early diagnosis of cancer based on biomedical imaging ensures effective treatment and a better prognosis. However, biomedical imaging presents challenges to both clinical institutions…

Computer Vision and Pattern Recognition · Computer Science 2023-01-24 Hosein Barzekar , Yash Patel , Ling Tong , Zeyun Yu