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Neural network representations are often analyzed as vectors in a fixed Euclidean space. However, their coordinates are not uniquely defined. If a hidden representation is transformed by an invertible linear map, the network function can be…

Machine Learning · Computer Science 2026-03-10 Jericho Cain

Graph generation techniques are increasingly being adopted for drug discovery. Previous graph generation approaches have utilized relatively small molecular building blocks such as atoms or simple cycles, limiting their effectiveness to…

Machine Learning · Computer Science 2020-04-21 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Deep learning has made significant breakthroughs in various fields of artificial intelligence. Advantages of deep learning include the ability to capture highly complicated features, weak involvement of human engineering, etc. However, it…

Software Engineering · Computer Science 2014-09-12 Lili Mou , Ge Li , Yuxuan Liu , Hao Peng , Zhi Jin , Yan Xu , Lu Zhang

The problem of accelerating drug discovery relies heavily on automatic tools to optimize precursor molecules to afford them with better biochemical properties. Our work in this paper substantially extends prior state-of-the-art on…

Chemical Physics · Physics 2019-10-22 Wengong Jin , Regina Barzilay , Tommi Jaakkola

In this work, we show that neural networks can be represented via the mathematical theory of quiver representations. More specifically, we prove that a neural network is a quiver representation with activation functions, a mathematical…

Machine Learning · Computer Science 2021-03-24 Marco Antonio Armenta , Pierre-Marc Jodoin

In recent years, huge progress has been made on learning neural implicit representations from multi-view images for 3D reconstruction. As an additional input complementing coordinates, using sinusoidal functions as positional encodings…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Sijia Jiang , Jing Hua , Zhizhong Han

Neural radiance fields (NeRFs) are able to synthesize realistic novel views from multi-view images captured from distinct positions and perspectives. In NeRF's rendering pipeline, neural networks are used to represent a scene independently…

Computer Vision and Pattern Recognition · Computer Science 2023-06-01 Kang Han , Wei Xiang , Lu Yu

Procuring expressive molecular representations underpins AI-driven molecule design and scientific discovery. The research mainly focuses on atom-level homogeneous molecular graphs, ignoring the rich information in subgraphs or motifs.…

Quantitative Methods · Quantitative Biology 2023-01-10 Fang Wu , Dragomir Radev , Stan Z. Li

Designing new molecules with a set of predefined properties is a core problem in modern drug discovery and development. There is a growing need for de-novo design methods that would address this problem. We present MolecularRNN, the graph…

Machine Learning · Computer Science 2019-06-03 Mariya Popova , Mykhailo Shvets , Junier Oliva , Olexandr Isayev

Computational models are quantitative representations of systems. By analyzing and comparing the outputs of such models, it is possible to gain a better understanding of the system itself. Though as the complexity of model outputs…

Machine Learning · Computer Science 2022-12-13 Colin G. Cess , Stacey D. Finley

Graphs are ubiquitous data structures for representing interactions between entities. With an emphasis on the use of graphs to represent chemical molecules, we explore the task of learning to generate graphs that conform to a distribution…

Machine Learning · Computer Science 2019-03-08 Qi Liu , Miltiadis Allamanis , Marc Brockschmidt , Alexander L. Gaunt

Neural implicit representations have emerged as a powerful paradigm for 3D reconstruction. However, despite their success, existing methods fail to capture fine geometric details and thin structures, especially in scenarios where only…

Computer Vision and Pattern Recognition · Computer Science 2025-04-23 Aarya Patel , Hamid Laga , Ojaswa Sharma

Benchmarks of molecular machine learning models often treat the molecular representation as a neutral input format, yet the representation defines the syntax of validity, edit operations, and invariances that models implicitly learn. We…

Programming Languages · Computer Science 2026-01-19 Oliver Goldstein , Samuel March

Implicit Neural Representations (INRs) are powerful to parameterize continuous signals in computer vision. However, almost all INRs methods are limited to low-level tasks, e.g., image/video compression, super-resolution, and image…

Computer Vision and Pattern Recognition · Computer Science 2023-12-04 Yiran Song , Qianyu Zhou , Lizhuang Ma

Molecular dynamics is a powerful simulation tool to explore material properties. Most of the realistic material systems are too large to be simulated with first-principles molecular dynamics. Classical molecular dynamics has lower…

Computational Physics · Physics 2021-01-11 Zun Wang , Chong Wang , Sibo Zhao , Shiqiao Du , Yong Xu , Bing-Lin Gu , Wenhui Duan

Molecular evolution is the process of simulating the natural evolution of molecules in chemical space to explore potential molecular structures and properties. The relationships between similar molecules are often described through…

Biomolecules · Quantitative Biology 2025-01-28 Kun Li , Longtao Hu , Xiantao Cai , Jia Wu , Wenbin Hu

Molecular Property Prediction (MPP) plays a pivotal role across diverse domains, spanning drug discovery, material science, and environmental chemistry. Fueled by the exponential growth of chemical data and the evolution of artificial…

Machine Learning · Computer Science 2024-08-23 Tanya Liyaqat , Tanvir Ahmad , Chandni Saxena

Complex-valued Neural Networks (CVNNs) are often motivated by domains where information is naturally encoded in magnitude and phase. Yet complex-valued inputs alone do not determine when complex arithmetic improves learning: the label…

Machine Learning · Computer Science 2026-05-28 Ashutosh Kumar

Neural fields, a category of neural networks trained to represent high-frequency signals, have gained significant attention in recent years due to their impressive performance in modeling complex 3D data, such as signed distance (SDFs) or…

Computer Vision and Pattern Recognition · Computer Science 2024-02-13 Marko Mihajlovic , Sergey Prokudin , Marc Pollefeys , Siyu Tang

Human visual perception carves a scene at its physical joints, decomposing the world into objects, which are selectively attended, tracked, and predicted as we engage our surroundings. Object representations emancipate perception from the…

Neurons and Cognition · Quantitative Biology 2021-09-09 Benjamin Peters , Nikolaus Kriegeskorte
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