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Trained on massive cross-species DNA corpora, DNA large language models (LLMs) learn the fundamental "grammar" and evolutionary patterns of genomic sequences. This makes them powerful priors for DNA sequence modeling, particularly over long…

Genomics · Quantitative Biology 2025-11-19 Rui Zhu , Xiaopu Zhou , Haixu Tang , Stephen W. Scherer , Lucila Ohno-Machado

Split learning (SL) enables collaborative training of large language models (LLMs) between resource-constrained edge devices and compute-rich servers by partitioning model computation across the network boundary. However, existing SL…

Machine Learning · Computer Science 2026-04-07 Aakriti Lnu , Zhe Li , Dandan Liang , Chao Huang , Rui Li , Haibo Yang

Attention efficiency is critical to large language model (LLM) inference. While prior advances optimize attention execution for individual requests (e.g., FlashAttention), production LLM serving relies on batching requests with highly…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-09 Rui Ning , Wei Zhang , Fan Lai

The deployment of large language models' (LLMs) inference at the edge can facilitate prompt service responsiveness while protecting user privacy. However, it is critically challenged by the resource constraints of a single edge node.…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-21 Peirong Zheng , Wenchao Xu , Haozhao Wang , Jinyu Chen , Xuemin Shen

Scaling inference for large language models (LLMs) is increasingly constrained by limited GPU memory, especially due to growing key-value (KV) caches required for long-context generation. While existing approaches offload KV caches to CPU…

Machine Learning · Computer Science 2025-07-08 Weishu Deng , Yujie Yang , Peiran Du , Lingfeng Xiang , Zhen Lin , Chen Zhong , Song Jiang , Hui Lu , Jia Rao

Hybrid Transformer architectures, which combine softmax attention blocks and recurrent neural networks (RNNs), have shown a desirable performance-throughput tradeoff for long-context modeling, but their adoption and studies are hindered by…

Computation and Language · Computer Science 2026-01-30 Yingfa Chen , Zhen Leng Thai , Zihan Zhou , Zhu Zhang , Xingyu Shen , Shuo Wang , Chaojun Xiao , Xu Han , Zhiyuan Liu

Large Language Model (LLM) serving faces a fundamental tension between stringent latency Service Level Objectives (SLOs) and limited GPU memory capacity. When high request rates exhaust the KV cache budget, existing LLM inference systems…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-20 Jiahuan Yu , Mingtao Hu , Zichao Lin , Minjia Zhang

As large language models (LLMs) continue to support increasingly longer contexts, the memory demand for key-value (KV) caches during decoding grows rapidly, becoming a critical bottleneck in both GPU memory capacity and PCIe bandwidth.…

Machine Learning · Computer Science 2025-06-23 Feiyu Yao , Qian Wang

Pre-trained transformer models with extended context windows are notoriously expensive to run at scale, often limiting real-world deployment due to their high computational and memory requirements. In this paper, we introduce Hamming…

Machine Learning · Computer Science 2025-02-05 Mark Horton , Tergel Molom-Ochir , Peter Liu , Bhavna Gopal , Chiyue Wei , Cong Guo , Brady Taylor , Deliang Fan , Shan X. Wang , Hai Li , Yiran Chen

Large language models (LLMs) are increasingly deployed under the Model-as-a-Service (MaaS) paradigm. To meet stringent quality-of-service (QoS) requirements, existing LLM serving systems disaggregate the prefill and decode phases of…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-20 Ao Xu , Han Zhao , Weihao Cui , Quan Chen , Yukang Chen , Shulai Zhang , Shuang Chen , Jiemin Jiang , Zhibin Yu , Minyi Guo

Transformer-based large language models (LLMs) demonstrate impressive performance across various natural language processing tasks. Serving LLM inference for generating long contents, however, poses a challenge due to the enormous memory…

Machine Learning · Computer Science 2024-07-01 Wonbeom Lee , Jungi Lee , Junghwan Seo , Jaewoong Sim

Deploying long-context large language models (LLMs) is essential but poses significant computational and memory challenges. Caching all Key and Value (KV) states across all attention heads consumes substantial memory. Existing KV cache…

Computation and Language · Computer Science 2024-10-15 Guangxuan Xiao , Jiaming Tang , Jingwei Zuo , Junxian Guo , Shang Yang , Haotian Tang , Yao Fu , Song Han

Network bound applications, like a database server executing OLTP queries or a caching server storing objects for a dynamic web applications, are essential services that consumers and businesses use daily. These services run on a large…

Hardware Architecture · Computer Science 2020-08-18 Siddharth Rai , Trevor E. Carlson

Existing sparse attention methods primarily target inference-time acceleration by selecting critical tokens under predefined sparsity patterns. However, they often fail to bridge the training-inference gap and lack the capacity for…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Feng Chen , Yefei He , Shaoxuan He , Yuanyu He , Jing Liu , Lequan Lin , Akide Liu , Zhaoyang Li , Jiyuan Zhang , Zhenbang Sun , Bohan Zhuang , Qi Wu

Multimodal large language models (MLLMs) enable powerful cross-modal reasoning capabilities but impose substantial computational and latency burdens, posing critical challenges for deployment on resource-constrained edge devices. In this…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-06 Zheming Yang , Qi Guo , Jun Wan , Jiarui Ruan , Yunqing Hu , Chang Zhao , Xiangyang Li

High-level synthesis (HLS) is a powerful tool for developing efficient hardware accelerators that rely on specialized memory systems to achieve sufficient on-chip data reuse and off-chip bandwidth utilization. However, even with HLS,…

Programming Languages · Computer Science 2026-01-26 Izumi Tanaka , Ken Sakayori , Shinya Takamaeda-Yamazaki , Naoki Kobayashi

The quadratic cost of attention limits the scalability of long-context LLMs, especially under limited hardware memory budgets. While attention is often sparse, existing static sparse methods cannot adapt to task- or input-dependent…

Computation and Language · Computer Science 2026-05-29 Siheng Xiong , Joe Zou , Faramarz Fekri , Yae Jee Cho

The Hierarchical Inference (HI) paradigm employs a tiered processing: the inference from simple data samples are accepted at the end device, while complex data samples are offloaded to the central servers. HI has recently emerged as an…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-06-17 Adarsh Prasad Behera , Roberto Morabito , Joerg Widmer , Jaya Prakash Champati

Deep-learning-based intelligent services have become prevalent in cyber-physical applications including smart cities and health-care. Collaborative end-edge-cloud computing for deep learning provides a range of performance and efficiency…

Machine Learning · Computer Science 2022-02-24 Sina Shahhosseini , Tianyi Hu , Dongjoo Seo , Anil Kanduri , Bryan Donyanavard , Amir M. Rahmani , Nikil Dutt

Disk-based graph indexes for approximate nearest neighbor search (ANNS) must serve latency-sensitive queries and throughput-demanding updates concurrently. We observe that over 40% of search-thread CPU time is spent stalling on disk I/O;…

Databases · Computer Science 2026-05-20 Juncheng Zhang , Yuanming Ren , Yongkun Li , Patrick P. C. Lee