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Assembly theory (AT) quantifies selection using the assembly equation and identifies complex objects that occur in abundance based on two measurements, assembly index and copy number, where the assembly index is the minimum number of…

Since the time of Darwin, scientists have struggled to reconcile the evolution of biological forms in a universe determined by fixed laws. These laws underpin the origin of life, evolution, human culture and technology, as set by the…

Evolution is often understood through genetic mutations driving changes in an organism's fitness, but there is potential to extend this understanding beyond the genetic code. We propose that natural products - complex molecules central to…

Populations and Evolution · Quantitative Biology 2024-09-11 Sebastian Pagel , Abhishek Sharma , Leroy Cronin

Assembly Theory (AT) was developed to help distinguish living from non-living systems. The theory is simple as it posits that the amount of selection or Assembly is a function of the number of complex objects where their complexity can be…

Other Quantitative Biology · Quantitative Biology 2024-06-12 Sara I. Walker , Cole Mathis , Stuart Marshall , Leroy Cronin

Assembly Theory (AT) is a theory that explains how to determine if a complex object is the product of evolution. Here we explain why attempts to compare AT to compression algorithms, ref 1, does not help identify if the object is the…

Information Theory · Computer Science 2024-03-28 Leroy Cronin

Assembly Theory (AT) and its central measure, the assembly index (Ai), represent an invaluable opportunity to address some of the most persistent and widespread conflations and misconceptions about computability and complexity theory in…

One thing that discriminates living things from inanimate matter is their ability to generate similarly complex or non-random architectures in a large abundance. From DNA sequences to folded protein structures, living cells, microbial…

Other Quantitative Biology · Quantitative Biology 2018-02-07 Stuart M. Marshall , Alastair R. G. Murray , Leroy Cronin

This work introduces a complexity measure which addresses some conflicting issues between existing ones by using a new principle - measuring the average amount of symmetry broken by an object. It attributes low (although different)…

Statistical Mechanics · Physics 2015-03-26 Roberto C. Alamino

We prove the full equivalence between Assembly Theory (AT) and Shannon Entropy via a method based upon the principles of statistical compression renamed `assembly index' that belongs to the LZ family of popular compression algorithms (ZIP,…

Information Theory · Computer Science 2024-04-04 Felipe S. Abrahão , Santiago Hernández-Orozco , Narsis A. Kiani , Jesper Tegnér , Hector Zenil

Selection is central to biological evolution, yet there has been no general experimental framework for quantifying selection in chemical systems before life. Here we demonstrate that selection in a prebiological chemical system can be…

Molecular Networks · Quantitative Biology 2025-12-23 Michael Jirasek , Abhishek Sharma , Mary Wong , Jennifer Munro , Leroy Cronin

The complexity of condensed matter arises from emergent behaviors that cannot be understood by analyzing individual constituents in isolation. While traditional condensed-matter approaches-developed primarily for ideal crystalline…

Materials Science · Physics 2025-09-30 Elisabetta Nocerino

How do we estimate the probability of an abundant objects' formation, with minimal context or assumption about is origin? To explore this we have previously introduced the concept of pathway assembly (as pathway complexity), in a graph…

Information Theory · Computer Science 2018-04-20 Alastair Murray , Stuart Marshall , Leroy Cronin

We study the build up of complexity on the example of 1 kg matter in different forms. We start on the simplest example of ideal gases, and then continue with more complex chemical, biological, life and social and technical structures. We…

Other Quantitative Biology · Quantitative Biology 2017-01-19 L. P. Csernai , S. F. Spinnangr , S. Velle

A measure called Physical Complexity is established and calculated for a population of sequences, based on statistical physics, automata theory, and information theory. It is a measure of the quantity of information in an organism's genome.…

Biological Physics · Physics 2011-12-02 Gerard Briscoe , Philippe De Wilde

Structural quantities such as order parameters and correlation functions are often employed to gain insight into the physical behavior and properties of condensed matter systems. While standard quantities for characterizing structure exist,…

Soft Condensed Matter · Physics 2017-08-23 Aaron S. Keys , Christopher R. Iacovella , Sharon C. Glotzer

To analyze the evolutionary emergence of structural complexity in physical processes we introduce a general, but tractable, model of objects that interact to produce new objects. Since the objects--\emph{$epsilon$-machines}--have well…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 James P. Crutchfield , Olof Gornerup

In contrast to entropy, which increases monotonically, the "complexity" or "interestingness" of closed systems seems intuitively to increase at first and then decrease as equilibrium is approached. For example, our universe lacked complex…

Statistical Mechanics · Physics 2014-05-28 Scott Aaronson , Sean M. Carroll , Lauren Ouellette

Here we demonstrate the first biochemistry-agnostic approach to map evolutionary relationships at the molecular scale, allowing the construction of phylogenetic models using mass spectrometry (MS) and Assembly Theory (AT) without…

Populations and Evolution · Quantitative Biology 2025-07-22 Amit Kahana , Alasdair MacLeod , Hessam Mehr , Abhishek Sharma , Emma Carrick , Michael Jirasek , Sara Walker , Leroy Cronin

We demonstrate that the assembly pathway method underlying assembly theory (AT) is an encoding scheme widely used by popular statistical compression algorithms. We show that in all cases (synthetic or natural) AT performs similarly to other…

Information Theory · Computer Science 2024-08-15 Abicumaran Uthamacumaran , Felipe S. Abrahão , Narsis A. Kiani , Hector Zenil

In metals additive manufacturing (AM), materials and components are concurrently made in a single process as layers of metal are fabricated on top of each other in the near-final topology required for the end-use product. Consequently, tens…

Applied Physics · Physics 2020-05-12 N. S. Johnson , P. S. Vulimiri , A. C. To , X. Zhang , C. A. Brice , B. B. Kappes , A. P. Stebner
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