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Generative artificial intelligence (AI) is rapidly transforming medical imaging by enabling capabilities such as data synthesis, image enhancement, modality translation, and spatiotemporal modeling. This review presents a comprehensive and…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Xuanru Zhou , Cheng Li , Shuqiang Wang , Ye Li , Tao Tan , Hairong Zheng , Shanshan Wang

As text-to-image generative models rapidly improve, AI researchers are making significant advances in developing domain-specific models capable of generating complex medical imagery from text prompts. Despite this, these technical…

A profound gap persists between artificial intelligence (AI) and clinical practice in medicine, primarily due to the lack of rigorous and cost-effective evaluation methodologies. State-of-the-art and state-of-the-practice AI model…

Purpose: The credibility of Artificial Intelligence (AI) models for medical imaging continues to be a challenge, affected by the diversity of models, the data used to train the models, and applicability of their combination to produce…

Image and Video Processing · Electrical Eng. & Systems 2026-02-18 Fakrul Islam Tushar , Lavsen Dahal , Saman Sotoudeh-Paima , Ehsan Abadi , W. Paul Segars , Ehsan Samei , Joseph Y. Lo

Clinical trials face mounting challenges: fragmented patient populations, slow enrollment, and unsustainable costs, particularly for late phase trials in oncology and rare diseases. While external control arms built from real-world data…

Machine Learning · Computer Science 2025-11-21 Perrine Chassat , Van Tuan Nguyen , Lucas Ducrot , Emilie Lanoy , Agathe Guilloux

Social problems stemming from the shortage of radiologists are intensifying, and artificial intelligence is being highlighted as a potential solution. Recently emerging large-scale generative AI has expanded from large language models…

Computer Vision and Pattern Recognition · Computer Science 2024-09-23 Inwoo Seo , Eunkyoung Bae , Joo-Young Jeon , Young-Sang Yoon , Jiho Cha

This review introduces the transformative potential of generative Artificial Intelligence (AI) and foundation models, including large language models (LLMs), for health technology assessment (HTA). We explore their applications in four…

Machine Learning · Computer Science 2024-09-24 Rachael Fleurence , Jiang Bian , Xiaoyan Wang , Hua Xu , Dalia Dawoud , Mitch Higashi , Jagpreet Chhatwal

With the continuous advancement of technology, artificial intelligence has significantly impacted various fields, particularly healthcare. Generative models, a key AI technology, have revolutionized medical image generation, data analysis,…

Machine Learning · Computer Science 2024-10-10 Yuan Sun , Jorge Ortiz

Radiology reporting generative AI holds significant potential to alleviate clinical workloads and streamline medical care. However, achieving high clinical accuracy is challenging, as radiological images often feature subtle lesions and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Yijian Gao , Dominic Marshall , Xiaodan Xing , Junzhi Ning , Giorgos Papanastasiou , Guang Yang , Matthieu Komorowski

Artificial intelligence (AI) holds great promise for supporting clinical trials, from patient recruitment and endpoint assessment to treatment response prediction. However, deploying AI without safeguards poses significant risks,…

Machine Learning · Computer Science 2025-10-09 Yao Chen , David Ohlssen , Aimee Readie , Gregory Ligozio , Ruvie Martin , Thibaud Coroller

Generative artificial intelligence (AI) is rapidly populating medical records with synthetic content, creating a feedback loop where future models are increasingly at risk of training on uncurated AI-generated data. However, the clinical…

Randomized controlled trials (RCTs) are indispensable for establishing the clinical value of medical artificial-intelligence (AI) tools, yet their high cost and long timelines hinder timely validation as new models emerge rapidly. Here, we…

Machine Learning · Computer Science 2025-11-17 Michael Nercessian , Wenxin Zhang , Alexander Schubert , Daphne Yang , Maggie Chung , Ahmed Alaa , Adam Yala

The demand for high-quality medical imaging in clinical practice and assisted diagnosis has made 3D image reconstruction in radiological imaging a key research focus. Artificial intelligence (AI) has emerged as a promising approach for…

Computer Vision and Pattern Recognition · Computer Science 2026-04-29 Yuezhe Yang , Lei Bi , Boyu Yang , Yaqian Wang , Yang He , Yige Peng , Zhe Jin , Xingbo Dong , Jinman Kim

Generative artificial intelligence (GenAI) has the potential to improve healthcare through automation that enhances the quality and safety of patient care. Powered by foundation models that have been pretrained and can generate complex…

Computers and Society · Computer Science 2024-07-25 Laleh Jalilian , Daniel McDuff , Achuta Kadambi

Influenced by ChatGPT, artificial intelligence (AI) large models have witnessed a global upsurge in large model research and development. As people enjoy the convenience by this AI large model, more and more large models in subdivided…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Liangrui Pan , Zhenyu Zhao , Ying Lu , Kewei Tang , Liyong Fu , Qingchun Liang , Shaoliang Peng

Generative AI systems such as ChatGPT and Claude are built upon language models that are typically evaluated for accuracy on curated benchmark datasets. Such evaluation paradigms measure predictive and reasoning capabilities of language…

Human-Computer Interaction · Computer Science 2025-03-03 Shreya Rajagopal , Jae Ho Sohn , Hari Subramonyam , Shiwali Mohan

The discussions around Artificial Intelligence (AI) and medical imaging are centered around the success of deep learning algorithms. As new algorithms enter the market, it is important for practicing radiologists to understand the pitfalls…

Image and Video Processing · Electrical Eng. & Systems 2022-11-28 Rishi Gadepally , Andrew Gomella , Eric Gingold , Paras Lakhani

From self-supervised, vision-only models to contrastive visual-language frameworks, computational pathology has rapidly evolved in recent years. Generative AI "co-pilots" now demonstrate the ability to mine subtle, sub-visual tissue cues…

Computer Vision and Pattern Recognition · Computer Science 2025-02-13 Mohsin Bilal , Aadam , Manahil Raza , Youssef Altherwy , Anas Alsuhaibani , Abdulrahman Abduljabbar , Fahdah Almarshad , Paul Golding , Nasir Rajpoot

The medical field is one of the important fields in the application of artificial intelligence technology. With the explosive growth and diversification of medical data, as well as the continuous improvement of medical needs and challenges,…

Artificial Intelligence · Computer Science 2024-03-27 Jingyu Xu , Binbin Wu , Jiaxin Huang , Yulu Gong , Yifan Zhang , Bo Liu

Recent advancements in artificial intelligence have significantly improved the automatic generation of radiology reports. However, existing evaluation methods fail to reveal the models' understanding of radiological images and their…

Artificial Intelligence · Computer Science 2024-08-27 Xiaoman Zhang , Julián N. Acosta , Hong-Yu Zhou , Pranav Rajpurkar
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