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Analyzing data from multiple sources offers valuable opportunities to improve the estimation efficiency of causal estimands. However, this analysis also poses many challenges due to population heterogeneity and data privacy constraints.…

Methodology · Statistics 2025-10-23 Rong Zhao , Jason Falvey , Xu Shi , Vernon M. Chinchilli , Chixiang Chen

Molecular generation and molecular property prediction are both crucial for drug discovery, but they are often developed independently. Inspired by recent studies, which demonstrate that diffusion model, a prominent generative approach, can…

Machine Learning · Computer Science 2025-04-07 Shikun Feng , Yuyan Ni , Yan Lu , Zhi-Ming Ma , Wei-Ying Ma , Yanyan Lan

Digitized, networked healthcare promises earlier detection, precision therapeutics, and continuous care; yet, it also expands the surface for privacy loss and compliance risk. We argue for a shift from siloed, application-specific…

Cryptography and Security · Computer Science 2026-01-09 M. Amin Rahimian , Benjamin Panny , James Joshi

In many applications, data can be heterogeneous in the sense of spanning latent groups with different underlying distributions. When predictive models are applied to such data the heterogeneity can affect both predictive performance and…

Machine Learning · Statistics 2022-05-04 Thomas Lartigue , Sach Mukherjee

Originated from distributed learning, federated learning enables privacy-preserved collaboration on a new abstracted level by sharing the model parameters only. While the current research mainly focuses on optimizing learning algorithms and…

Machine Learning · Computer Science 2020-09-17 Cong Wang , Yuanyuan Yang , Pengzhan Zhou

Here we describe two approaches to improve group information management (GIM) and draw on the results of prior works to implement them in software prototypes. The first aids browsing and retrieving from large and unfamiliar collections like…

Human-Computer Interaction · Computer Science 2022-09-27 Jesse David Dinneen , Sascha Donner , Helen Bubinger , Jwen Fai Low , Maja Krtalić

Privacy data protection in the medical field poses challenges to data sharing, limiting the ability to integrate data across hospitals for training high-precision auxiliary diagnostic models. Traditional centralized training methods are…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Tian Bowen , Xu Zhengyang , Yin Zhihao , Wang Jingying , Yue Yutao

Over the past decade alongside increased focus on computational reproducibility significant efforts have been made to define reproducibility. However, these definitions provide a textual description rather than a framework. The community…

Computational Engineering, Finance, and Science · Computer Science 2026-01-06 Meznah Aloqalaa , Stian Soiland-Reyes , Carole Goble

Novel technologies in genomics allow creating data in exascale dimension with relatively minor effort of human and laboratory and thus monetary resources compared to capabilities only a decade ago. While the availability of this data…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-11-10 Sandra Gesing , Thomas Richard Connor , Ian Taylor

Although data-driven methods usually have noticeable performance on disease diagnosis and treatment, they are suspected of leakage of privacy due to collecting data for model training. Recently, federated learning provides a secure and…

Artificial Intelligence · Computer Science 2023-06-27 Yawei Zhao , Qinghe Liu , Xinwang Liu , Kunlun He

Scientific practice typically involves repeatedly studying a system, each time trying to unravel a different perspective. In each study, the scientist may take measurements under different experimental conditions (interventions,…

Machine Learning · Statistics 2014-03-11 Sofia Triantafillou , Ioannis Tsamardinos

The healthcare system collects extensive data, encompassing patient administrative information, clinical measurements, and home-monitored health metrics. To support informed decision-making in patient care and treatment management, it is…

Human-Computer Interaction · Computer Science 2024-09-18 Faisal Zaki Roshan , Abhishek Ahuja , Fateme Rajabiyazdi

In applications where the study data are collected within cluster units (e.g., patients within transplant centers), it is often of interest to estimate and perform inference on the treatment effects of the cluster units. However, it is…

Applications · Statistics 2023-05-11 Nicholas Hartman , Kevin He

One of the notable fields in studying the genetics of cancer is disease gene identification which affects disease treatment and drug discovery. Many researches have been done in this field. Genome-wide association studies (GWAS) are one of…

Computational Engineering, Finance, and Science · Computer Science 2016-04-27 Zahra Razaghi-Moghadama , Razieh Abdollahia , Sama Goliaeib , Morteza Ebrahimia

In clinical research, the lack of events of interest often necessitates imbalanced learning. One approach to resolve this obstacle is data integration or sharing, but due to privacy concerns neither is practical. Therefore, there is an…

Machine Learning · Computer Science 2020-09-01 Seok-Ju Hahn , Junghye Lee

Multisite medical data sharing is critical in modern clinical practice and medical research. The challenge is to conduct data sharing that preserves individual privacy and data usability. The shortcomings of traditional privacy-enhancing…

There has been much research activity in recent times about providing the data infrastructures needed for the provision of personalised healthcare. In particular the requirement of integrating multiple, potentially distributed,…

Databases · Computer Science 2008-12-16 Andrew Branson , Tamas Hauer , Richard McClatchey , Dmitry Rogulin , Jetendr Shamdasani

The rapid growth in data availability has facilitated research and development, yet not all industries have benefited equally due to legal and privacy constraints. The healthcare sector faces significant challenges in utilizing patient data…

Methodology · Statistics 2025-11-18 Katariina Perkonoja , Kari Auranen , Joni Virta

We present a novel approach for differentially private data synthesis of protected tabular datasets, a relevant task in highly sensitive domains such as healthcare and government. Current state-of-the-art methods predominantly use…

Machine Learning · Computer Science 2024-07-30 Konstantin Donhauser , Javier Abad , Neha Hulkund , Fanny Yang

Multiple technologies that measure expression levels of protein mixtures in the human body offer a potential for detection and understanding the disease. The recent increase of these technologies prompts researchers to evaluate the…

Machine Learning · Computer Science 2026-05-12 Michal Valko , Richard Pelikan , Miloš Hauskrecht