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Sparse autoencoders (SAEs) have recently emerged as a powerful tool for interpreting the internal representations of large language models (LLMs), revealing latent latent features with semantical meaning. This interpretability has also…

Other Quantitative Biology · Quantitative Biology 2025-07-11 Haoxiang Guan , Jiyan He , Jie Zhang

Sparse Autoencoder (SAE) has emerged as a powerful tool for mechanistic interpretability of large language models. Recent works apply SAE to protein language models (PLMs), aiming to extract and analyze biologically meaningful features from…

Quantitative Methods · Quantitative Biology 2026-01-21 Xiangyu Liu , Haodi Lei , Yi Liu , Yang Liu , Wei Hu

Large Language Models (LLMs) have transformed natural language processing, yet their internal mechanisms remain largely opaque. Recently, mechanistic interpretability has attracted significant attention from the research community as a…

Machine Learning · Computer Science 2025-09-24 Dong Shu , Xuansheng Wu , Haiyan Zhao , Daking Rai , Ziyu Yao , Ninghao Liu , Mengnan Du

Sparse autoencoders (SAEs) are a mechanistic interpretability technique that have been used to provide insight into learned concepts within large protein language models. Here, we employ TopK and Ordered SAEs to investigate autoregressive…

Predicting protein function from amino acid sequence remains a central challenge in data-scarce (low-$N$) regimes, limiting machine learning-guided protein design when only small amounts of assay-labeled sequence-function data are…

Machine Learning · Computer Science 2025-08-27 Darin Tsui , Kunal Talreja , Amirali Aghazadeh

Deep learning, particularly with the advancement of Large Language Models, has transformed biomolecular modeling, with protein language models such as ESM inspiring emerging RNA language models such as RiNALMo. Recent work has begun…

Biomolecules · Quantitative Biology 2026-05-18 Taehan Kim , Sangdae Nam

Protein language models have revolutionized structure prediction, but their nonlinear nature obscures how sequence representations inform structure prediction. While sparse autoencoders (SAEs) offer a path to interpretability here by…

Biomolecules · Quantitative Biology 2025-03-13 Nithin Parsan , David J. Yang , John J. Yang

Sparse autoencoders (SAEs) have lately been used to uncover interpretable latent features in large language models. By projecting dense embeddings into a much higher-dimensional and sparse space, learned features become disentangled and…

Machine Learning · Computer Science 2025-07-30 Viktoria Schuster

Protein language models (PLMs) have demonstrated remarkable success in protein modeling and design, yet their internal mechanisms for predicting structure and function remain poorly understood. Here we present a systematic approach to…

Biomolecules · Quantitative Biology 2024-12-18 Elana Simon , James Zou

The ability of large language models (LLMs) to follow instructions is crucial for their practical applications, yet the underlying mechanisms remain poorly understood. This paper presents a novel framework that leverages sparse autoencoders…

Machine Learning · Computer Science 2025-02-18 Zirui He , Haiyan Zhao , Yiran Qiao , Fan Yang , Ali Payani , Jing Ma , Mengnan Du

Understanding the multilingual mechanisms of large language models (LLMs) provides insight into how they process different languages, yet this remains challenging. Existing studies often focus on individual neurons, but their polysemantic…

Sparse Autoencoders (SAEs) provide potentials for uncovering structured, human-interpretable representations in Large Language Models (LLMs), making them a crucial tool for transparent and controllable AI systems. We systematically analyze…

Machine Learning · Computer Science 2026-02-03 Jack Gallifant , Shan Chen , Kuleen Sasse , Hugo Aerts , Thomas Hartvigsen , Danielle S. Bitterman

Mechanistic interpretability of large language models (LLMs) aims to uncover the internal processes of information propagation and reasoning. Sparse autoencoders (SAEs) have demonstrated promise in this domain by extracting interpretable…

Machine Learning · Computer Science 2025-05-26 Wei Shi , Sihang Li , Tao Liang , Mingyang Wan , Guojun Ma , Xiang Wang , Xiangnan He

Understanding the internal machinations of deep Transformer-based NLP models is more crucial than ever as these models see widespread use in various domains that affect the public at large, such as industry, academia, finance, health. While…

Computation and Language · Computer Science 2026-05-13 Dan Pluth , Zachary Nicholas Houghton , Yu Zhou , Vijay K. Gurbani

Pathology plays an important role in disease diagnosis, treatment decision-making and drug development. Previous works on interpretability for machine learning models on pathology images have revolved around methods such as attention value…

Sparse autoencoders (SAEs) enable feature-level mechanistic interpretability and activation steering in large language models (LLMs), but SAE-based language control remains unreliable in multilingual settings: most SAEs are trained on…

Computation and Language · Computer Science 2026-05-25 Yusser Al Ghussin , Daniil Gurgurov , Tanja Baeumel , Josef van Genabith , Patrick Schramowski , Simon Ostermann

Sparse Autoencoders (SAEs) have emerged as a popular tool for interpreting the hidden states of large language models (LLMs). By learning to reconstruct activations from a sparse bottleneck layer, SAEs discover interpretable features from…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Matthew Lyle Olson , Musashi Hinck , Neale Ratzlaff , Changbai Li , Phillip Howard , Vasudev Lal , Shao-Yen Tseng

While the activations of neurons in deep neural networks usually do not have a simple human-understandable interpretation, sparse autoencoders (SAEs) can be used to transform these activations into a higher-dimensional latent space which…

Machine Learning · Computer Science 2025-08-07 Gonçalo Paulo , Alex Mallen , Caden Juang , Nora Belrose

To truly understand vision models, we must not only interpret their learned features but also validate these interpretations through controlled experiments. While earlier work offers either rich semantics or direct control, few post-hoc…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Samuel Stevens , Wei-Lun Chao , Tanya Berger-Wolf , Yu Su

Large language models (LLMs) excel at handling human queries, but they can occasionally generate flawed or unexpected responses. Understanding their internal states is crucial for understanding their successes, diagnosing their failures,…

Computation and Language · Computer Science 2025-02-24 Xuansheng Wu , Jiayi Yuan , Wenlin Yao , Xiaoming Zhai , Ninghao Liu
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