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Predicting the effect of mutations in proteins is one of the most critical challenges in protein engineering; by knowing the effect a substitution of one (or several) residues in the protein's sequence has on its overall properties, could…

Computational Engineering, Finance, and Science · Computer Science 2020-10-08 David Medina-Ortiz , Sebastian Contreras , Juan Amado-Hinojosa , Jorge Torres-Almonacid , Juan A. Asenjo , Marcelo Navarrete , Álvaro Olivera-Nappa

From self-assembly and protein folding to combinatorial metamaterials, a key challenge in material design is finding the right combination of interacting building blocks that yield targeted properties. Such structures are fiendishly…

Soft Condensed Matter · Physics 2025-06-26 Ryan van Mastrigt , Marjolein Dijkstra , Martin van Hecke , Corentin Coulais

We developed new modified embedded-atom method (MEAM) interatomic potentials for the Mg-Al alloy system using a first-principles method based on density functional theory (DFT). The materials parameters, such as the cohesive energy,…

Materials Science · Physics 2013-05-29 B. Jelinek , J. Houze , Sungho Kim , M. F. Horstemeyer , M. I. Baskes , Seong-Gon Kim

The parameters of many-body potentials for Co, Nb and Zr metals, based on the embedded-atom method, have been systematically derived. The analytical potential scheme allows us to reproduce correctly the cohesive energies and structural…

Materials Science · Physics 2014-05-02 Pascal Thibaudeau , Julian Gale

The numerical computation of chemical potential in dense, non-homogeneous fluids is a key problem in the study of confined fluids thermodynamics. To this day several methods have been proposed, however there is still need for a robust…

Chemical Physics · Physics 2018-05-09 Claudio Perego , Omar Valsson , Michele Parrinello

Atomistic modeling of solid-solid battery interfaces is essential for understanding electro-chemo-mechanical coupling, but the complex interfacial chemistry and heterogeneous environments pose major challenges for quantum-accurate,…

Materials Science · Physics 2026-01-27 Xiaoqing Liu , Xinyu Yu , Yangshuai Wang , Zhe-Tao Sun , Zedong Luo , Kehan Zeng , Teng Zhao , Shou-Hang Bo , Zhenli Xu

Mg alloys are promising lightweight structural materials due to their low density and excellent mechanical properties. However, their limited formability and ductility necessitate improvements in these properties, specifically through…

We present a new scheme to extract numerically ``optimal'' interatomic potentials from large amounts of data produced by first-principles calculations. The method is based on fitting the potential to ab initio atomic forces of many atomic…

Condensed Matter · Physics 2009-10-22 Furio Ercolessi , James B. Adams

Over the past decade inter-atomic potentials based on machine-learning (ML) techniques have become an indispensable tool in the atomic-scale modeling of materials. Trained on energies and forces obtained from electronic-structure…

Materials Science · Physics 2022-08-15 Michele Ceriotti

Many popular methods for the calculation of chemical potentials rely on the insertion of test particles into the target system. In the case of liquids and liquid mixtures, this procedure increases in difficulty upon increasing density or…

Soft Condensed Matter · Physics 2018-02-23 Maziar Heidari , Kurt Kremer , Robinson Cortes-Huerto , Raffaello Potestio

Grain boundary (GB) segregation in magnesium (Mg) substantially influences its mechanical properties and performance. Atomic-scale modelling, typically using ab-initio or semi-empirical approaches, has mainly focused on GB segregation at…

Two-component mixture models are particularly useful for identifying differentially expressed genes, but their performance can deteriorate markedly when the alternative distribution departs from parametric assumptions or symmetry. We…

Methodology · Statistics 2026-03-18 Sangkon Oh , Geoffrey J. McLachlan

Multi-principal element alloys open large composition spaces for alloy development. The large compositional space necessitates rapid synthesis and characterization to identify promising materials, as well as predictive strategies for alloy…

Surrogate machine-learning models are transforming computational materials science by predicting properties of materials with the accuracy of ab initio methods at a fraction of the computational cost. We demonstrate surrogate models that…

Learning the distance metric between pairs of samples has been studied for image retrieval and clustering. With the remarkable success of pair-based metric learning losses, recent works have proposed the use of generated synthetic points on…

Computer Vision and Pattern Recognition · Computer Science 2020-04-24 Byungsoo Ko , Geonmo Gu

Concise and reliable modeling for aggregating power flexibility of distributed energy resources in active distribution networks (ADNs) is a crucial technique for coordinating transmission and distribution networks. Our recent research has…

Systems and Control · Electrical Eng. & Systems 2023-12-11 Yilin Wen , Zechun Hu , Jinhua He , Yi Guo

We describe the application of the locally-self-consistent-multiple-scattering (LSMS)[1] method to amorphous alloys. The LSMS algorithm is optimized for the Intel XP/S-150, a multiple-instruction-multiple-data parallel computer with 1024…

Condensed Matter · Physics 2009-10-28 J. C. Swihart , D. M. C. Nicholson , G. M. Stocks , Y. Wang , W. A. Shelton , H. Yang

Coarse-graining (CG) enables molecular dynamics (MD) simulations of larger systems and longer timescales that are otherwise infeasible with atomistic models. Machine learning potentials (MLPs), with their capacity to capture many-body…

Chemical Physics · Physics 2025-12-01 Weilong Chen , Franz Görlich , Paul Fuchs , Julija Zavadlav

The augmented Lagrangiam method (ALM), widely used in quantum chemistry constrained optimization problems, is applied in the context of the nuclear Density Functional Theory (DFT) in the self-consistent constrained Skyrme…

Nuclear Theory · Physics 2014-11-21 A. Staszczak , M. Stoitsov , A. Baran , W. Nazarewicz

We introduce Adjoint Sampling, a highly scalable and efficient algorithm for learning diffusion processes that sample from unnormalized densities, or energy functions. It is the first on-policy approach that allows significantly more…

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