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In this study, we explore how the combination of synthetic biology, neuroscience modeling, and neuromorphic electronic systems offers a new approach to creating an artificial system that mimics the natural sense of smell. We argue that a…

Neural and Evolutionary Computing · Computer Science 2025-08-04 Kevin Max , Larissa Sames , Shimeng Ye , Jan Steinkühler , Federico Corradi

Machine olfaction is rapidly emerging as a transformative capability, with applications spanning non-invasive medical diagnostics, industrial monitoring, agriculture, and security and defense. Recent advances in stabilizing mammalian…

Navigation by scent is a capability in robotic systems that is rising in demand. However, current methods often suffer from ambiguities, particularly when robots misattribute odours to incorrect objects due to limitations in olfactory…

Robotics · Computer Science 2025-09-23 Kordel K. France , Ovidiu Daescu

Odor visualization translates odor information and perception into visual outcomes and arouses the corresponding olfactory synesthesia, surpassing the spatial limitation that odors can only be perceived where they are present. Traditional…

Human-Computer Interaction · Computer Science 2026-02-05 Gang Yu , Yuchi Sun , Weining Yan , Xinyu Wang , Qi Lu

Olfaction sensing in autonomous robotics faces challenges in dynamic operations, energy efficiency, and edge processing. It necessitates a machine learning algorithm capable of managing real-world odor interference, ensuring resource…

Signal Processing · Electrical Eng. & Systems 2024-07-09 Rizwana Kausar , Fakhreddine Zayer , Jaime Viegas , Jorge Dias

Advances in neural sensing technology are making it possible to observe the olfactory process in great detail. In this paper, we conceptualize smell from a Data Science and AI perspective, that relates the properties of odorants to how they…

Neurons and Cognition · Quantitative Biology 2024-04-09 Vivek Agarwal , Joshua Harvey , Dmitry Rinberg , Vasant Dhar

The olfactory system employs responses of an ensemble of odorant receptors (ORs) to sense molecules and to generate olfactory percepts. Here we hypothesized that ORs can be viewed as 3D spatial filters that extract molecular features…

Machine Learning · Computer Science 2024-12-13 Sergey Shuvaev , Khue Tran , Khristina Samoilova , Cyrille Mascart , Alexei Koulakov

Odor sensory evaluation has a broad application in food, clothing, cosmetics, and other fields. Traditional artificial sensory evaluation has poor repeatability, and the machine olfaction represented by the electronic nose (E-nose) is…

Artificial Intelligence · Computer Science 2023-11-27 Xiuxin Xia , Yuchen Guo , Yanwei Wang , Yuchao Yang , Yan Shi , Hong Men

Odor detection underpins food safety, environmental monitoring, medical diagnostics, and many more fields. The current artificial sensors developed for odor detection struggle with complex mixtures while non-invasive recordings lack…

Machine Learning · Computer Science 2025-08-14 Matin Hassanloo , Ali Zareh , Mehmet Kemal Özdemir

Deep learning methods have been widely applied to visual and acoustic technology. In this paper, we proposed an odor labeling convolutional encoder-decoder (OLCE) for odor identification in machine olfaction. OLCE composes a convolutional…

Machine Learning · Computer Science 2021-01-07 Tengteng Wen , Zhuofeng Mo , Jingshan Li , Qi Liu , Liming Wu , Dehan Luo

Olfactory perception plays a critical role in both human and organismal interactions, yet understanding of its underlying mechanisms and influencing factors remain insufficient. Molecular structures influence odor perception through…

Machine Learning · Computer Science 2025-02-04 HongXin Xie , JianDe Sun , Yi Shao , Shuai Li , Sujuan Hou , YuLong Sun , Jian Wang

Molecular odor prediction is the process of using a molecule's structure to predict its smell. While accurate prediction remains challenging, AI models can suggest potential odors. Existing methods, however, often rely on basic descriptors…

Machine Learning · Computer Science 2025-05-02 Hong Xin Xie , Jian De Sun , Fan Fu Xue , Zi Fei Han , Shan Shan Feng , Qi Chen

Animals have evolved to rapidly detect and recognise brief and intermittent encounters with odour packages, exhibiting recognition capabilities within milliseconds. Artificial olfaction has faced challenges in achieving comparable results…

Olfaction -- how molecules are perceived as odors to humans -- remains poorly understood. Recently, the principal odor map (POM) was introduced to digitize the olfactory properties of single compounds. However, smells in real life are not…

Machine Learning · Computer Science 2025-01-28 Gary Tom , Cher Tian Ser , Ella M. Rajaonson , Stanley Lo , Hyun Suk Park , Brian K. Lee , Benjamin Sanchez-Lengeling

Olfaction lies at the intersection of chemical structure, neural encoding, and linguistic perception, yet existing representation methods fail to fully capture this pathway. Current approaches typically model only isolated segments of the…

Computation and Language · Computer Science 2026-04-21 Yanyi Su , Hongshuai Wang , Zhifeng Gao , Jun Cheng

Predicting the relationship between a molecule's structure and its odor remains a difficult, decades-old task. This problem, termed quantitative structure-odor relationship (QSOR) modeling, is an important challenge in chemistry, impacting…

Humankind mimics the processes and strategies that nature has perfected and uses them as a model to address its problems. That has recently found a new direction, i.e., a novel communication technology called molecular communication (MC),…

Signal Processing · Electrical Eng. & Systems 2023-11-30 Dilara Aktas , Beyza Ezgi Ortlek , Meltem Civas , Elham Baradari , Ayse Sila Okcu , Melanie Whitfield , Oktay Cetinkaya , Ozgur Baris Akan

The olfactory sense measures the chemical composition of the environment using a diverse array of olfactory receptors. In vertebrates, the olfactory receptors reside in a mucus layer in the nasal cavity and can thus only detect odorants…

Biological Physics · Physics 2023-01-25 Swati Sen , David Zwicker

Molecular odor prediction has great potential across diverse fields such as chemistry, pharmaceuticals, and environmental science, enabling the rapid design of new materials and enhancing environmental monitoring. However, current methods…

Machine Learning · Computer Science 2025-02-04 HongXin Xie , JianDe Sun , Yi Shao , Shuai Li , Sujuan Hou , YuLong Sun , Yuxiang Liu

One of the key challenges to predict odor from molecular structure is unarguably our limited understanding of the odor space and the complexity of the underlying structure-odor relationships. Here, we show that the predictive performance of…

Quantitative Methods · Quantitative Biology 2025-08-14 Akshay Sajan , Stijn Sluis , Reza Haydarlou , Sanne Abeln , Pasquale Lisena , Raphael Troncy , Caro Verbeek , Inger Leemans , Halima Mouhib
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