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Causal inference is a vital aspect of multiple scientific disciplines and is routinely applied to high-impact applications such as medicine. However, evaluating the performance of causal inference methods in real-world environments is…

Machine Learning · Computer Science 2023-07-04 Mathieu Chevalley , Yusuf Roohani , Arash Mehrjou , Jure Leskovec , Patrick Schwab

Estimating causal effects from observational data is inherently challenging due to the lack of observable counterfactual outcomes and even the presence of unmeasured confounding. Traditional methods often rely on restrictive, untestable…

Methodology · Statistics 2025-04-07 Li Chen , Xiaotong Shen , Wei Pan

Causal inference in spatio-temporal settings is critically hindered by unmeasured confounders with complex spatio-temporal dynamics and the prevalence of multi-resolution data. While diffusion models present a promising avenue for…

Machine Learning · Statistics 2026-04-07 Xinwen Liu , Lei Qian , Song Xi Chen , Niansheng Tang

Method validation and study design in causal inference rely on synthetic data with known counterfactuals. Existing simulators trade off distributional realism, the ability to capture mixed-type and multimodal tabular data, against causal…

Methodology · Statistics 2026-03-05 Qi Zhang , Harsh Parikh , Ashley Naimi , Razieh Nabi , Christopher Kim , Timothy Lash

A single-pass driving clip frequently results in incomplete scanning of the road structure, making reconstructed scene expanding a critical requirement for sensor simulators to effectively regress driving actions. Although contemporary 3D…

Computer Vision and Pattern Recognition · Computer Science 2025-07-28 Sicong Du , Jiarun Liu , Qifeng Chen , Hao-Xiang Chen , Tai-Jiang Mu , Sheng Yang

Deep neural networks can obtain impressive performance on various tasks under the assumption that their training domain is identical to their target domain. Performance can drop dramatically when this assumption does not hold. One…

Machine Learning · Computer Science 2024-10-10 Gaël Gendron , Michael Witbrock , Gillian Dobbie

Spatially resolved transcriptomics is a fast-developing set of technologies that enables the measurement of localized gene expression across spatial locations in a sample. Detecting spatially varying genes is critical for analyzing such…

Applications · Statistics 2026-04-22 Pritam Dey , Rajarshi Guhaniyogi , Yang Ni , Bani K. Mallick

Single-cell gene expression measurements encode variability spanning molecular noise, cell-to-cell heterogeneity, and technical artifacts. Mechanistic stochastic models provide powerful approaches to disentangle these sources, yet inferring…

Quantitative Methods · Quantitative Biology 2025-09-19 Christopher E. Miles

Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in…

Machine Learning · Statistics 2017-10-31 Dustin Tran , David M. Blei

Human organs constantly undergo anatomical changes due to a complex mix of short-term (e.g., heartbeat) and long-term (e.g., aging) factors. Evidently, prior knowledge of these factors will be beneficial when modeling their future state,…

Computer Vision and Pattern Recognition · Computer Science 2023-06-19 Jee Seok Yoon , Chenghao Zhang , Heung-Il Suk , Jia Guo , Xiaoxiao Li

Causal discovery aims to infer causal relationships among variables from observational data, typically represented by a directed acyclic graph (DAG). Most existing methods assume independent and identically distributed observations, an…

Methodology · Statistics 2026-03-27 Alex Chen , Qing Zhou

Endowing deep models with the ability to generalize in dynamic scenarios is of vital significance for real-world deployment, given the continuous and complex changes in data distribution. Recently, evolving domain generalization (EDG) has…

Machine Learning · Computer Science 2025-07-01 Zhuo He , Shuang Li , Wenze Song , Longhui Yuan , Jian Liang , Han Li , Kun Gai

Causal inference is essential for developing and evaluating medical interventions, yet real-world medical datasets are often difficult to access due to regulatory barriers. This makes synthetic data a potentially valuable asset that enables…

Machine Learning · Computer Science 2025-10-22 Harry Amad , Zhaozhi Qian , Dennis Frauen , Julianna Piskorz , Stefan Feuerriegel , Mihaela van der Schaar

Complex systems with intricate causal dependencies challenge accurate prediction. Effective modeling requires precise physical process representation, integration of interdependent factors, and incorporation of multi-resolution…

Machine Learning · Computer Science 2025-04-08 Xuechun Li , Shan Gao , Susu Xu

Diffusion probabilistic models (DPMs) have become the state-of-the-art in high-quality image generation. However, DPMs have an arbitrary noisy latent space with no interpretable or controllable semantics. Although there has been significant…

Machine Learning · Computer Science 2024-08-27 Aneesh Komanduri , Chen Zhao , Feng Chen , Xintao Wu

Causal discovery algorithms based on probabilistic graphical models have emerged in geoscience applications for the identification and visualization of dynamical processes. The key idea is to learn the structure of a graphical model from…

Machine Learning · Computer Science 2015-12-29 Imme Ebert-Uphoff , Yi Deng

We study causal discovery from a single observed sequence of discrete events generated by a stochastic process, as encountered in vehicle logs, manufacturing systems, or patient trajectories. This regime is particularly challenging due to…

Machine Learning · Computer Science 2026-03-18 Hugo Math , Rainer Lienhart

Predicting how genetic perturbations change cellular state is a core problem for building controllable models of gene regulation. Perturbations targeting the same gene can produce different transcriptional responses depending on their…

Genomics · Quantitative Biology 2026-02-12 Boyang Fu , George Dasoulas , Sameer Gabbita , Xiang Lin , Shanghua Gao , Xiaorui Su , Soumya Ghosh , Marinka Zitnik

Existing 3D scene generation methods often struggle to model the complex logical dependencies and physical constraints between objects, limiting their ability to adapt to dynamic and realistic environments. We propose CausalStruct, a novel…

Graphics · Computer Science 2025-09-22 Shen Chen , Ruiyu Zhao , Jiale Zhou , Zongkai Wu , Jenq-Neng Hwang , Lei Li

The presence of interference, where the outcome of an individual may depend on the treatment assignment and behavior of neighboring nodes, can lead to biased causal effect estimation. Current approaches to network experiment design focus on…

Machine Learning · Computer Science 2024-05-22 Zahra Fatemi , Jean Pouget-Abadie , Elena Zheleva