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Under mild Markov assumptions, sufficient conditions for strict minimax optimality of sequential tests for multiple hypotheses under distributional uncertainty are derived. First, the design of optimal sequential tests for simple hypotheses…

Statistics Theory · Mathematics 2020-10-26 Michael Fauss , Abdelhak M. Zoubir , H. Vincent Poor

Two-sample hypothesis testing-determining whether two sets of data are drawn from the same distribution-is a fundamental problem in statistics and machine learning with broad scientific applications. In the context of nonparametric testing,…

Machine Learning · Statistics 2026-04-21 Antoine Chatalic , Marco Letizia , Nicolas Schreuder , Lorenzo Rosasco

We present the expected values from p-value hacking as a choice of the minimum p-value among $m$ independents tests, which can be considerably lower than the "true" p-value, even with a single trial, owing to the extreme skewness of the…

Applications · Statistics 2018-01-29 Nassim Nicholas Taleb

This article considers change point testing and estimation for a sequence of high-dimensional data. In the case of testing for a mean shift for high-dimensional independent data, we propose a new test which is based on $U$-statistic in Chen…

Statistics Theory · Mathematics 2021-08-10 Runmin Wang , Changbo Zhu , Stanislav Volgushev , Xiaofeng Shao

Permutation tests are among the simplest and most widely used statistical tools. Their p-values can be computed by a straightforward sampling of permutations. However, this way of computing p-values is often so slow that it is replaced by…

Computation · Statistics 2018-07-27 Jean-Marie Droz

Given a randomized experiment with binary outcomes, exact confidence intervals for the average causal effect of the treatment can be computed through a series of permutation tests. This approach requires minimal assumptions and is valid for…

Methodology · Statistics 2025-06-19 P. M. Aronow , Haoge Chang , Patrick Lopatto

A common problem in genetics is that of testing whether a set of highly dependent gene expressions differ between two populations, typically in a high-dimensional setting where the data dimension is larger than the sample size. Most…

Methodology · Statistics 2015-03-11 Måns Thulin

We propose a class of nonparametric two-sample tests with a cost linear in the sample size. Two tests are given, both based on an ensemble of distances between analytic functions representing each of the distributions. The first test uses…

Machine Learning · Statistics 2015-06-16 Kacper Chwialkowski , Aaditya Ramdas , Dino Sejdinovic , Arthur Gretton

Statistical hypothesis testing and effect size measurement are routine parts of quantitative research. Advancements in computer processing power have greatly improved the capability of statistical inference through the availability of…

Methodology · Statistics 2024-01-18 Michael J. Crosse , John J. Foxe , Sophie Molholm

We prove bounds on statistical distances between high-dimensional exchangeable mixture distributions (which we call \emph{permutation mixtures}) and their i.i.d. counterparts. Our results are based on a novel method for controlling $\chi^2$…

Statistics Theory · Mathematics 2025-09-17 Yanjun Han , Jonathan Niles-Weed

A number of biomedical problems require performing many hypothesis tests, with an attendant need to apply stringent thresholds. Often the data take the form of a series of predictor vectors, each of which must be compared with a single…

Methodology · Statistics 2014-05-13 Yi-Hui Zhou , Fred Wright

This paper is concerned with the problem of conditional independence testing for discrete data. In recent years, researchers have shed new light on this fundamental problem, emphasizing finite-sample optimality. The non-asymptotic viewpoint…

Statistics Theory · Mathematics 2023-10-31 Ilmun Kim , Matey Neykov , Sivaraman Balakrishnan , Larry Wasserman

Given a predictor of outcome derived from a high-dimensional dataset, pre-validation is a useful technique for comparing it to competing predictors on the same dataset. For microarray data, it allows one to compare a newly derived predictor…

Applications · Statistics 2008-07-28 Holger Höfling , Robert Tibshirani

Reliable estimation of feature contributions in machine learning models is essential for trust, transparency and regulatory compliance, especially when models are proprietary or otherwise operate as black boxes. While permutation-based…

Machine Learning · Statistics 2025-12-24 Albert Dorador

In many applied sciences a popular analysis strategy for high-dimensional data is to fit many multivariate generalized linear models in parallel. This paper presents a novel approach to address the resulting multiple testing problem by…

Statistics Theory · Mathematics 2024-10-07 Riccardo De Santis , Jelle J. Goeman , Samuel Davenport , Jesse Hemerik , Livio Finos

Permutation tests are a powerful and flexible approach to inference via resampling. As computational methods become more ubiquitous in the statistics curriculum, use of permutation tests has become more tractable. At the heart of the…

Methodology · Statistics 2025-06-09 Johanna Hardin , Lauren Quesada , Julie Ye , Nicholas J. Horton

The K-sample testing problem involves determining whether K groups of data points are each drawn from the same distribution. Analysis of variance is arguably the most classical method to test mean differences, along with several recent…

Machine Learning · Statistics 2024-10-04 Sambit Panda , Cencheng Shen , Ronan Perry , Jelle Zorn , Antoine Lutz , Carey E. Priebe , Joshua T. Vogelstein

When permutation methods are used in practice, often a limited number of random permutations are used to decrease the computational burden. However, most theoretical literature assumes that the whole permutation group is used, and methods…

Statistics Theory · Mathematics 2018-08-20 Jesse Hemerik , Jelle Goeman

The scan statistic is by far the most popular method for anomaly detection, being popular in syndromic surveillance, signal and image processing, and target detection based on sensor networks, among other applications. The use of the scan…

Methodology · Statistics 2016-11-28 Ery Arias-Castro , Rui M. Castro , Ervin Tánczos , Meng Wang

Permutation testing is a non-parametric method for obtaining the max null distribution used to compute corrected $p$-values that provide strong control of false positives. In neuroimaging, however, the computational burden of running such…

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