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Deep brain stimulation(DBS)has become an effective intervention for advanced Parkinson's disease, but the exact mechanism of DBS is still unclear. In this review, we discuss the history of DBS, the anatomy and internal architecture of the…

Neurons and Cognition · Quantitative Biology 2023-03-24 Yongtong Wu , Kejia Hu , Shenquan Liu

Machine Learning models are increasingly used for decision making, in particular in high-stakes applications such as credit scoring, medicine or recidivism prediction. However, there are growing concerns about these models with respect to…

Machine Learning · Computer Science 2023-04-12 Julien Rouzot , Julien Ferry , Marie-José Huguet

We consider the problem of finding an n-agent joint-policy for the optimal finite-horizon control of a decentralized Pomdp (Dec-Pomdp). This is a problem of very high complexity (NEXP-hard in n >= 2). In this paper, we propose a new…

Artificial Intelligence · Computer Science 2016-03-28 Raghav Aras , Alain Dutech , François Charpillet

Binarized Neural Networks (BNNs) have recently attracted significant interest due to their computational efficiency. Concurrently, it has been shown that neural networks may be overly sensitive to "attacks" - tiny adversarial changes in the…

Machine Learning · Computer Science 2018-10-09 Elias B. Khalil , Amrita Gupta , Bistra Dilkina

We propose a mixed-integer linear program (MILP) for multi-agent motion planning that embeds Polytopic Action-based Motion Planning (PAAMP) into a sequence-then-solve pipeline. Region sequences confine each agent to adjacent convex…

Robotics · Computer Science 2026-03-19 Akshay Jaitly , Jack Cline , Siavash Farzan

Multiscale modelling presents a multifaceted perspective into understanding the mechanisms of the brain and how neurodegenerative disorders like Parkinson's disease (PD) manifest and evolve over time. In this study, we propose a novel…

Neurons and Cognition · Quantitative Biology 2025-09-18 Aaron Herrera , Hina Shaheen

Mixed-Integer Programming (MIP), particularly Mixed-Integer Linear Programming (MILP) and Mixed-Integer Quadratic Programming (MIQP), has found extensive applications in domains such as portfolio optimization and network flow control, which…

Optimization and Control · Mathematics 2026-02-03 Zayn Wang

Cutting planes (cuts) are crucial for solving Mixed Integer Linear Programming (MILP) problems. Advanced MILP solvers typically rely on manually designed heuristic algorithms for cut selection, which require much expert experience and…

Optimization and Control · Mathematics 2024-12-11 Xuefeng Zhang , Liangyu Chen , Zhengfeng Yang , Zhenbing Zeng

Decoding motor performance from brain signals offers promising avenues for adaptive deep brain stimulation (aDBS) for Parkinson's disease (PD). In a two-center cohort of 19 PD patients executing a drawing task, we decoded motor performance…

In this paper, we describe a comprehensive algorithmic framework for solving mixed integer bilevel linear optimization problems (MIBLPs) using a generalized branch-and-cut approach. The framework presented merges features from existing…

Optimization and Control · Mathematics 2021-04-20 Sahar Tahernejad , Ted K. Ralphs , Scott T. DeNegre

Integer linear programming (ILP) is an elegant approach to solve linear optimization problems, naturally described using integer decision variables. Within the context of physics-inspired machine learning applied to chemistry, we…

Mixed integer bilinear programs (MIBLPs) offer tools to resolve robotics motion planning problems with orthogonal rotation matrices or static moment balance, but require long solving times. Recent work utilizing data-driven methods has…

Robotics · Computer Science 2024-08-02 Xuan Lin , Gabriel Ikaika Fernandez , Dennis Hong

In many applications, a combinatorial problem must be repeatedly solved with similar, but distinct parameters. Yet, the parameters $w$ are not directly observed; only contextual data $d$ that correlates with $w$ is available. It is tempting…

Machine Learning · Computer Science 2024-07-23 Daniel McKenzie , Samy Wu Fung , Howard Heaton

In recent years, large-scale pre-trained multimodal models (LMM) generally emerge to integrate the vision and language modalities, achieving considerable success in various natural language processing and computer vision tasks. The growing…

Computer Vision and Pattern Recognition · Computer Science 2024-01-29 Xinyao Yu , Hao Sun , Ziwei Niu , Rui Qin , Zhenjia Bai , Yen-Wei Chen , Lanfen Lin

Mixed integer linear programming (MILP) solvers expose hundreds of parameters that have an outsized impact on performance but are difficult to configure for all but expert users. Existing machine learning (ML) approaches require training on…

Machine Learning · Computer Science 2025-09-25 Connor Lawless , Yingxi Li , Anders Wikum , Madeleine Udell , Ellen Vitercik

Adaptive deep brain stimulation (aDBS) has emerged as a promising treatment for Parkinson disease (PD). In aDBS, a surgically placed electrode sends dynamically altered stimuli to the brain based on neurophysiological feedback: an invasive…

Neurons and Cognition · Quantitative Biology 2025-05-16 Ekaterina Kuzmina , Dmitrii Kriukov , Mikhail Lebedev , Dmitry V. Dylov

We propose a new algorithm for solving multistage stochastic mixed integer linear programming (MILP) problems with complete continuous recourse. In a similar way to cutting plane methods, we construct nonlinear Lipschitz cuts to build lower…

Optimization and Control · Mathematics 2019-05-24 Shabbir Ahmed , Filipe Goulart Cabral , Bernardo Freitas Paulo da Costa

In this paper, we consider the network slicing problem which attempts to map multiple customized virtual network requests (also called services) to a common shared network infrastructure and allocate network resources to meet diverse…

Information Theory · Computer Science 2022-03-01 Wei-Kun Chen , Ya-Feng Liu , Yu-Hong Dai , Zhi-Quan Luo

We introduce a mixed integer program (MIP) for assigning importance scores to each neuron in deep neural network architectures which is guided by the impact of their simultaneous pruning on the main learning task of the network. By…

Machine Learning · Computer Science 2023-07-26 Mostafa ElAraby , Guy Wolf , Margarida Carvalho

Mixed-integer linear programs (MILPs) are widely used in artificial intelligence and operations research to model complex decision problems like scheduling and routing. Designing such programs however requires both domain and modelling…

Artificial Intelligence · Computer Science 2021-07-16 Mohit Kumar , Samuel Kolb , Luc De Raedt , Stefano Teso
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